IL-6 activates HSP72 gene expression in human skeletal muscle.

abstract：:Female Wistar rats were fed on a high fat diet for 18 weeks, during which their energy intake increased by 25% and body weight by 50% due to a doubling of adipose tissue tissue stores. Animals were then treated with increasing doses of a sheep polyclonal antiserum to rat adipocytes on days 1-4 and 7 after which they r...

journal_title：Biochemical and biophysical research communications

authors： Flint DJ

更新日期：1998-11-09 00:00:00

abstract：:Wnt/beta-catenin signaling plays an important role not only in cancer, but also in cancer stem cells. In this study, we found that beta-catenin and OCT-4 was highly expressed in cisplatin (DDP) selected A549 cells. Stimulating A549 cells with lithium chloride (LiCl) resulted in accumulation of beta-catenin and up-regu...

journal_title：Biochemical and biophysical research communications

authors： Teng Y,Wang X,Wang Y,Ma D

更新日期：2010-02-12 00:00:00

abstract：:Sterols are essential membrane components of eukaryotic cells and are important for membrane organization and function. Cholesterol is the most representative sterol present in higher eukaryotes. It is often found distributed non-randomly in domains or pools in biological and model membranes. Cholesterol-rich function...

journal_title：Biochemical and biophysical research communications

authors： Arora A,Raghuraman H,Chattopadhyay A

更新日期：2004-06-11 00:00:00

abstract：:Insulin degrading enzyme (IDE) is a thiol-dependent metalloendoprotease that is responsible for initiation of cellular insulin degradation. However, its exact mode of action and the factors controlling it are poorly understood. Since IDE is a metal requiring enzyme, we have examined which metal(s) is(are) endogenously...

journal_title：Biochemical and biophysical research communications

authors： Ebrahim A,Hamel FG,Bennett RG,Duckworth WC

更新日期：1991-12-31 00:00:00

abstract：:Destruxin B, a peptide antibiotic, inhibits vacuolar-type ATPase (V-ATPase) specifically and dose-dependently among ATPases examined. Acidification of intracellular organelles is also blocked by destruxin B at comparable concentrations when assessed by accumulation of acridine orange. The inhibitory activity of destru...

journal_title：Biochemical and biophysical research communications

authors： Muroi M,Shiragami N,Takatsuki A

更新日期：1994-12-15 00:00:00

abstract：:We report here that at least seven low Mr GTP-binding proteins (range 21.5 to 29 kDa) are associated with the membranes of zymogen granules from rat pancreas. GTP binding proteins of similar Mr but in different relative proportions were found in the cytosolic fraction. Treatment of intact granules with either trypsin ...

journal_title：Biochemical and biophysical research communications

authors： Padfield PJ,Jamieson JD

更新日期：1991-01-31 00:00:00

abstract：:Cilostazol is a drug licensed for the treatment of intermittent claudication. Its main action is to elevate intracellular levels of cyclic monophosphate (cAMP) by inhibiting the activity of type III phosphodiesterase, a cAMP-degrading enzyme. The effects of cilostazol on fatty acid oxidation (FAO) are as yet unknown. ...

journal_title：Biochemical and biophysical research communications

authors： Wang B,Zhu L,Sui S,Sun C,Jiang H,Ren D

更新日期：2014-05-09 00:00:00

abstract：:The cDNAs for two casein kinase-1 homologs, hhp1 and hhp2, have been isolated from Schizosaccharomyces pombe and characterized. Their corresponding genes reside on chromosomes II and I, respectively, and encode approximately 42-46 kDa proteins that are related structurally to the HRR25 gene product of budding yeast. O...

journal_title：Biochemical and biophysical research communications

authors： Kearney PH,Ebert M,Kuret J

更新日期：1994-08-30 00:00:00

abstract：:Papiliocin is a 37-residue peptide isolated from the swallowtail butterfly Papilio xuthus. In this study, we found that Papiliocin induced the accumulation of reactive oxygen species (ROS) and hydroxyl radicals known to be important regulators of apoptosis in Candida albicans. To examine the relationship between the a...

journal_title：Biochemical and biophysical research communications

authors： Hwang B,Hwang JS,Lee J,Kim JK,Kim SR,Kim Y,Lee DG

更新日期：2011-04-29 00:00:00

abstract：:Galectins (gal), a family of soluble beta-galactoside-binding proteins present at the cell surface, are involved in cancer progression and metastasis. Here we investigated the expression of several galectins in normal (PrEC), benign (BPH-1), and malignant (LNCaP) prostate epithelial cells and found that all galectins,...

journal_title：Biochemical and biophysical research communications

authors： Ahmed H,Banerjee PP,Vasta GR

更新日期：2007-06-22 00:00:00

abstract：:It has been proposed that the estrogen receptor bears proteolytic activity responsible for its own transformation. This activity was inhibited by aprotinin. Incubation of transformed ER with aprotinin modified the proteolytic digestion of the hormone binding subunit by proteinase K. The smallest hormone-binding fragme...

journal_title：Biochemical and biophysical research communications

authors： Nigro V,Medici N,Abbondanza C,Minucci S,Moncharmont B,Molinari AM,Puca GA

更新日期：1990-07-31 00:00:00

abstract：:A synthetic peptide corresponding to the seven carboxy-terminal amino acids of tyrosine aminotransferase was coupled to ovalbumin or keyhole limpet haemocyanin, and the resulting conjugates were used to raise anti-peptide antibodies by immunization of rabbits. The crude sera were purified and tested for recognition of...

journal_title：Biochemical and biophysical research communications

authors： Dietrich JB,Genot G,Beck G

更新日期：1987-04-29 00:00:00

abstract：:Signaling via the type 1 insulin-like growth factor receptor (IGF1R) confers resistance to EGF receptor (EGFR) inhibitors. It is plausible that reciprocal EGFR compensation could mediate resistance to IGF1R inhibition, prompting us to investigate effects of IGF1R depletion on EGFR signaling in breast cancer cells expr...

journal_title：Biochemical and biophysical research communications

authors： Riedemann J,Sohail M,Macaulay VM

更新日期：2007-04-13 00:00:00

abstract：:While Aspergillus ficuum phytaseA (phyA) was rapidly inactivated by 1,2-cyclohexanedione and phenylglyoxal, both specific modifiers of arginine, phytaseB (phyB) showed a markedly different behavior. First, phyB was totally insensitive to 1,2-cyclohexanedione even in the presence of 0.2 M guanidinium hydrochloride; sec...

journal_title：Biochemical and biophysical research communications

authors： Ullah AH,Sethumadhavan K

更新日期：1998-02-13 00:00:00

abstract：:Infrared spectra of E. coli strain JM103 and transformants which overproduced recombinant proinsulin have been measured as a function of pressure up to 38 kbar. It is the first time that high-pressure infrared spectra of live bacteria have been successfully measured. In ambient conditions, spectra of the host strain J...

journal_title：Biochemical and biophysical research communications

authors： Wong PT,Zahab DM,Narang SA,Sung WL

更新日期：1987-07-15 00:00:00

abstract：:(6R)5,6,7,8 tetrahydrobiopterin (6-BH4) is an important cofactor in the regulation of melanogenesis in melanocytes, where it controls: (a) the supply of L-tyrosine from L-phenylalanine via phenylalanine hydroxylase, and (b) regulates directly dopaquinone formation from L-tyrosine via tyrosinase. 6-BH4 undergoes redox-...

journal_title：Biochemical and biophysical research communications

authors： Schallreuter KU,Büttner G,Pittelkow MR,Wood JM,Swanson NN,Körner C

更新日期：1994-10-14 00:00:00

abstract：:Lateral diffusion coefficients (D) of two surface differentiation antigens (sIgM and Bp35) were determined on interferon-sensitive (-IFs) or resistant (-IFr) Daudi cells by fluorescence photobleaching, using monospecific FITC-anti-IgM or PE-anti-Leu 16 probes. For untreated Daudi -IFs, mean (D) were 5.8 and 5.3 (x10(-...

journal_title：Biochemical and biophysical research communications

authors： Balint E,Aszalos A,Grimley PM

更新日期：1988-12-15 00:00:00

abstract：:Eye absent (Eya) proteins are involved in cell fate determination in a broad spectrum of cells and tissues. Aberrant expression of Eya2 has been documented in a variety of cancers and correlates with clinical outcome. However, whether microRNAs (miRNAs) can regulate Eya2 expression remains unknown. Here, we show that ...

journal_title：Biochemical and biophysical research communications

authors： Fu J,Xu X,Kang L,Zhou L,Wang S,Lu J,Cheng L,Fan Z,Yuan B,Tian P,Zheng X,Yu C,Ye Q,Lv Z

更新日期：2014-03-07 00:00:00

abstract：:Activities of the hepadnavirus polymerases are known to include those of DNA polymerase, reverse transcriptase and RNase H. To date, it has been difficult or impossible to clone and express the product as an active enzyme. In this study, full length capped RNA encoding Duck Hepatitis B Virus (DHBV) polymerase was prod...

journal_title：Biochemical and biophysical research communications

authors： Howe AY,Elliott JF,Tyrrell DL

更新日期：1992-12-15 00:00:00

abstract：:Tetrahymena p85 is localized to the presumptive division plane before division furrow formation; its molecular weight in SDS-polyacrylamide gel electrophoresis differs in wild-type and temperature-sensitive cell-division-arrest mutant cdaA1 cells. At the restrictive temperature, p85 localization and division furrow fo...

journal_title：Biochemical and biophysical research communications

authors： Gonda K,Nishibori K,Ohba H,Watanabe A,Numata O

更新日期：1999-10-14 00:00:00

abstract：:To investigate the structural basis for human interferon gamma (huIFN gamma) binding to intracellular regions of the human IFN gamma receptor (huIFN gamma R), we have subcloned and expressed the huIFN gamma R free of fusion proteins in the yeast strain Pichia pastoris. HuIFN gamma bound to the cytoplasmic domain of th...

journal_title：Biochemical and biophysical research communications

authors： Green MM,Larkin J 3rd,Subramaniam PS,Szente BE,Johnson HM

更新日期：1998-02-04 00:00:00

abstract：:A real-time RT-PCR assay using newly designed primers was developed to analyze developmental and adult MHC mRNA expression both in skeletal muscles and single fibers. Only 4 ng of total RNA was necessary for the analysis of the relative mRNA expression of MHC genes. Different validation steps were realized concerning ...

journal_title：Biochemical and biophysical research communications

authors： Sanchez H,Chapot R,Banzet S,Koulmann N,Birot O,Bigard AX,Peinnequin A

更新日期：2006-02-03 00:00:00

abstract：:Primary aldosteronism is an important, potentially curable, form of hypertension. We examined the possible association between restriction fragment length polymorphisms in the atrial natriuretic peptide (ANP) gene and responsiveness of aldosterone to angiotensin II in 59 patients with primary aldosteronism due to aldo...

journal_title：Biochemical and biophysical research communications

authors： Tunny TJ,Jonsson JR,Klemm SA,Ballantine DM,Stowasser M,Gordon RD

更新日期：1994-11-15 00:00:00

abstract：:Metastatic hepatocellular carcinoma (HCC) remains a mostly incurable disease. The fact that the identity of the mechanisms that regulate metastasis in HCC is known hampers the development of anti-metastatic therapies. Currently, there is no effective treatment for HCC once it is progressed to metastatic stage. Therefo...

journal_title：Biochemical and biophysical research communications

authors： Wu Y,Liu ZG,Shi MQ,Yu HZ,Jiang XY,Yang AH,Fu XS,Xu Y,Yang S,Ni H,Shen SJ,Li WD

更新日期：2017-09-16 00:00:00

abstract：:Neutrophil discharge of calcium into the ambient medium was measured, using an ion-sensitive electrode, after cells were stimulated with phorbol myristate acetate. Dose-dependent calcium efflux was observed over the same range of stimulus concentrations associated with specific granule marker release. Calcium efflux w...

journal_title：Biochemical and biophysical research communications

authors： Styrt B,Schwartz MA,Klempner MS

更新日期：1988-08-15 00:00:00

abstract：:The structure of intracellular third loop peptide (betaIII-2: RRSSKFCLKEKKALK) was studied by CD and NMR spectroscopy. According to the CD study, this peptide forms a helix in the TFE solution. The three-dimensional molecular structure in TFE was determined by the 2D (1)H NMR spectroscopy. The structure consists of a ...

journal_title：Biochemical and biophysical research communications

authors： Okuda A,Matsumoto O,Akaji M,Taga T,Ohkubo T,Kobayashi Y

更新日期：2002-03-15 00:00:00

abstract：:There is a major unmet medical need for effective and well tolerated treatment options for cancer. The search now seeks to identify active biomolecules with multiple targets. Lupeol, an important dietary triterpenoid known as anticarcinogen by inducing apoptosis. But it is still more to reveal the potency of lupeol in...

journal_title：Biochemical and biophysical research communications

authors： Vijay Avin BR,Prabhu T,Ramesh CK,Vigneshwaran V,Riaz M,Jayashree K,Prabhakar BT

更新日期：2014-05-30 00:00:00

abstract：:Nuclear factor kappaB (NF-kappaB) is a ubiquitous transcription factor activated by various stimuli implicated in heart failure progression. However, its activation in heart failure has not been well defined yet. Therefore, we investigated activation of NF-kappaB after myocardial infarction. For the first time, we per...

journal_title：Biochemical and biophysical research communications

authors： Tillmanns J,Carlsen H,Blomhoff R,Valen G,Calvillo L,Ertl G,Bauersachs J,Frantz S

更新日期：2006-04-14 00:00:00

abstract：:Aralin from Aralia elata is a newly identified type II ribosome- inactivating protein, which preferentially induces apoptosis in cancer cells. In this study, we identified that the aralin receptor is a 110-kDa high-density lipoprotein-binding protein (HDLBP), which functions as a HDL receptor. The sensitivities of tum...

journal_title：Biochemical and biophysical research communications

authors： Otsuka H,Gotoh Y,Komeno T,Ono T,Kawasaki Y,Iida N,Shibagaki Y,Hattori S,Tomatsu M,Akiyama H,Tashiro F

更新日期：2014-10-10 00:00:00

abstract：:l-Aspartyl (l-Asp) and l-asparaginyl residues in proteins isomerize or racemize to d,l-isoaspartyl (d,l-isoAsp) or d-aspartyl (d-Asp) residues during protein aging. These atypical aspartyl residues can interfere with the biological function of the protein and lead to cellular dysfunction. Protein l-isoaspartyl (d-aspa...

journal_title：Biochemical and biophysical research communications

authors： Kosugi S,Furuchi T,Katane M,Sekine M,Shirasawa T,Homma H

更新日期：2008-06-20 00:00:00