Cilostazol induces mitochondrial fatty acid β-oxidation in C2C12 myotubes.

abstract：:The rfp/ret transforming gene was generated by DNA rearrangement which occurred during transfection of NIH 3T3 cells. The amino-terminal half of Rfp with a RING finger motif was fused to the truncated Ret receptor tyrosine kinase, leading to a transforming sequence, Rfp/Ret. In the present study, to elucidate the impo...

journal_title：Biochemical and biophysical research communications

authors： Hasegawa N,Iwashita T,Asai N,Murakami H,Iwata Y,Isomura T,Goto H,Hayakawa T,Takahashi M

更新日期：1996-08-14 00:00:00

abstract：:The promoter of the GATA-4 gene was analyzed in P19CL6 cells. A 124bp segment containing conserved two GC-boxes and E-box was essential for the basal promoter activity, as determined with a transient luciferase reporter gene assay. However, an extended 1312 bp reporter construct but not the 124 bp segment, when ligate...

journal_title：Biochemical and biophysical research communications

authors： Ishibashi T,Yokura Y,Ohashi K,Yamamoto H,Maeda M

更新日期：2011-09-23 00:00:00

abstract：:We previously found a new endogenous factor in rat liver cytosol, named ATP-stimulated glucocorticoid-receptor translocation promoter (ASTP), that increased the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP. We have cloned and sequenced a cDNA (2989 bp) encoding the ASTP protein. An ope...

journal_title：Biochemical and biophysical research communications

authors： Okamoto K,Hirano H,Isohashi F

更新日期：1993-06-30 00:00:00

abstract：:The presence of a variety of cytokine-like molecules (IL-1 alpha, IL-1 beta, IL-2, IL-6, TNF-alpha) in the hemocytes of two molluscs, i.e., Planorbarius corneus and Viviparus ater, is reported. These molecules are present only in hemocytes with phagocytic activity. These data, together with recent reports on the prese...

journal_title：Biochemical and biophysical research communications

authors： Ottaviani E,Franchini A,Franceschi C

更新日期：1993-09-15 00:00:00

abstract：:Viral mRNA encoding vesicular stomatitis virus glycoprotein sequences was detected and quantitated using a DNA-hybridization dot-blot technique. This assay was employed to determine if the synthetic double-stranded polynucleotide complex of polyriboinosinic-polyribocytidylic acid would elicit viral resistance in vitro...

journal_title：Biochemical and biophysical research communications

authors： Thomson MS,Bird RC,Stringfellow DA,Rossi CR,Lauerman LH

更新日期：1991-02-28 00:00:00

abstract：:2-Hydroxy-5-nitrobenzyl bromide, a highly reactive reagent towards tryptophan residues in proteins, is shown to activate the passive proton flux through the inner mitochondrial membrane of bovine heart submitochondrial particles (ETPH). When added at low concentrations, the reagent increased both the ATPase activity o...

journal_title：Biochemical and biophysical research communications

authors： Solaini G,Baracca A,Parenti Castelli G,Rossi CA

更新日期：1988-08-30 00:00:00

abstract：:The E2F activity plays a critical role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. We describe here molecular cloning and functional characterization of a fifth member of the E2F family of transcription factors. E2F-...

journal_title：Biochemical and biophysical research communications

authors： Vaishnav YN,Vaishnav MY,Pant V

更新日期：1998-01-26 00:00:00

abstract：:To examine the possible role of lipids as adhesion receptors for infection, Chlamydia trachomatis and Chlamydia pneumoniae were labeled with 125I and layered on thin-layer chromatograms (tlc) of separated lipids isolated from target cells, and bound bacteria were detected by autoradiography. Elementary bodies from bot...

journal_title：Biochemical and biophysical research communications

authors： Krivan HC,Nilsson B,Lingwood CA,Ryu H

更新日期：1991-03-29 00:00:00

abstract：:The 160 kDa alpha-mannosidase (E.C. 3.2.1.24) isolated from culture filtrate of Trichoderma reesei has wide aglycon specificity but cleaves the alpha1 --> 2 and alpha1 --> 3 mannosidic bonds with higher rate than alpha1 --> 6 bond and slowly hydrolyses yeast mannan and 1,6-alpha-mannan. The specific activity of the en...

journal_title：Biochemical and biophysical research communications

authors： Eneyskaya EV,Kulminskaya AA,Savel'ev AN,Shabalin KA,Golubev AM,Neustroev KN

更新日期：1998-04-07 00:00:00

abstract：:The aim of the present study was to accomplish de novo generation of reconstituted human skin with enriched hair follicles. Dermal papillae (DP) are known to play a crucial organizing role in hair follicle induction. However, generation of enriched human hair follicles using cultured DP cells has not been accomplished...

journal_title：Biochemical and biophysical research communications

authors： Yoshida Y,Soma T,Matsuzaki T,Kishimoto J

更新日期：2019-08-27 00:00:00

abstract：:Apoptosis and autophagy are crucial mechanisms regulating cell death, and the relationship between apoptosis and autophagy in the liver has yet to be thoroughly explored. TIGAR (TP53-induced glycolysis and apoptosis regulator), which is a p53-inducible gene, functions in the suppression of ROS (reactive oxygen species...

journal_title：Biochemical and biophysical research communications

authors： Ye L,Zhao X,Lu J,Qian G,Zheng JC,Ge S

更新日期：2013-07-26 00:00:00

abstract：:Recent studies have highlighted that cancer cells with a loss of the SWI/SNF complex catalytic subunit BRG1 are dependent on the remaining ATPase, BRM, making it an attractive target for cancer therapy. However, an understanding of the extent of target inhibition required to arrest cell growth, necessary to develop an...

journal_title：Biochemical and biophysical research communications

authors： Rago F,DiMare MT,Elliott G,Ruddy DA,Sovath S,Kerr G,Bhang HC,Jagani Z

更新日期：2019-01-01 00:00:00

abstract：:Wheat germ derivatives have been shown to inhibit inflammation-related diseases. In this study, a small peptide (YDWPGGRN) isolated from wheat germ was used to study its anti-inflammatory activity and its application in skin wound healing. Both the in vitro and in vivo results clearly showed that YDWPGGRN significantl...

journal_title：Biochemical and biophysical research communications

authors： Sui H,Wang F,Weng Z,Song H,Fang Y,Tang X,Shen X

更新日期：2020-04-16 00:00:00

abstract：:Activated Kupffer cells and hepatic macrophages can produce massive liver necrosis through microcirculatory disturbance due to sinusoidal fibrin deposition. This mechanism is involved in the development of liver injury after endotoxin administration in rats pretreated with heat-killed Propionibacterium acnes (P.acnes)...

journal_title：Biochemical and biophysical research communications

authors： Toshima K,Mochida S,Ishikawa K,Matsui A,Arai M,Ogata I,Fujiwara K

更新日期：1998-05-29 00:00:00

abstract：:The catalytic and immunological properties of acid phosphatases (EC 3.1.3.2.) in different tissues were studied. It was demonstrated that high uptake forms of lysosomal enzymes like beta-galactosidase isolated from human platelets and bovine testis are mature enzymes, which have not lost their mannose-6phosphate marke...

journal_title：Biochemical and biophysical research communications

authors： Hu P,Parenti G,Keulemans J,Hoogeveen AT

更新日期：1990-03-16 00:00:00

abstract：:Quite extraordinarily molybdenum is an essential element in life for the uptake of nitrogen from both nitrogen gas and nitrate, yet it is a relatively rare heavy trace element. It also functions in a few extremely important oxygen-atom transfer reactions at low redox potential. This review poses the question "Why does...

journal_title：Biochemical and biophysical research communications

authors： Williams RJ,Fraústo da Silva JJ

更新日期：2002-03-29 00:00:00

abstract：:Menin, encoded by the multiple endocrine neoplasia type 1 (MEN1) gene, is a tumor suppressor and transcription regulator. Menin interacts with various proteins as a scaffold protein and is proposed to play important roles in multiple physiological and pathological processes by controlling gene expression, proliferatio...

journal_title：Biochemical and biophysical research communications

authors： Kim B,Song TY,Jung KY,Kim SG,Cho EJ

更新日期：2017-10-07 00:00:00

abstract：:Rats consume most of their daily food intake at night; serum leptin levels and adipose tissue leptin mRNA content are elevated at night in non-lactating rats fed ad libitum. Lactation induces massive hyperphagia with most food still consumed at night, but the nocturnal increase in leptin secretion was not observed in ...

journal_title：Biochemical and biophysical research communications

authors： Pickavance L,Tadayyon M,Williams G,Vernon RG

更新日期：1998-07-09 00:00:00

abstract：:The immunoproteasome is a multicatalytic protease complex in all eukaryotic cells, which plays a key role in regulating essential cellular processes. However, the role of immunoproteasome subunit β2i in regulation of cardiac fibrosis and inflammation in deoxycorticosterone-acetate (DOCA)/salt mice remains unknown. Wil...

journal_title：Biochemical and biophysical research communications

authors： Yan W,Bi HL,Liu LX,Li NN,Liu Y,Du J,Wang HX,Li HH

更新日期：2017-08-19 00:00:00

abstract：:Copper is a micronutrient that is required for proper metabolic functioning of most prokaryotic and eukaryotic organisms. To sustain an adequate supply of copper, a cell requires molecular mechanisms that control the metal content to avoid copper toxicity. This toxicity comes primarily from the reactivity of copper, w...

journal_title：Biochemical and biophysical research communications

authors： Latorre M,Olivares F,Reyes-Jara A,López G,González M

更新日期：2011-03-25 00:00:00

abstract：:The internucleosomal cleavage of genomic DNA is a biochemical hallmark of apoptosis. DNase gamma, a Mg2+/Ca2+-dependent endonuclease, has been suggested to be one of the apoptotic endonucleases, but its biochemical characteristic has not been fully elucidated. Here, using recombinant DNase gamma, we showed that DNase ...

journal_title：Biochemical and biophysical research communications

authors： Mizuta R,Mizuta M,Araki S,Shiokawa D,Tanuma S,Kitamura D

更新日期：2006-06-30 00:00:00

abstract：:Cycloprodigiosin hydrochloride (cPrG.HCl), a member of the prodigiosin family, is a red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. cPrG.HCl markedly suppressed 3H-thymidine incorporation by concanavalin A stimulated murine splenocytes but had little effect on lipopolysaccharide depende...

journal_title：Biochemical and biophysical research communications

authors： Kawauchi K,Shibutani K,Yagisawa H,Kamata H,Nakatsuji S,Anzai H,Yokoyama Y,Ikegami Y,Moriyama Y,Hirata H

更新日期：1997-08-28 00:00:00

abstract：:Spinal and bulbar muscular atrophy (SBMA) is one of a group of human inherited neurodegenerative diseases caused by polyglutamine expansion. There is increasing evidence that generation of truncated proteins containing an expanded polyglutamine tract may be an important step in the pathogenesis of these disorders. We ...

journal_title：Biochemical and biophysical research communications

authors： Kobayashi Y,Miwa S,Merry DE,Kume A,Mei L,Doyu M,Sobue G

更新日期：1998-11-09 00:00:00

abstract：:The sequence of tryptic and chymotryptic peptides from cytosolic and mitochondrial rabbit liver serine hydroxymethyltransferase are compared to the proposed sequence of a protein coded for by the glyA gene of Escherichia coli. The E. coli glyA gene is believed to code for serine hydroxymethyltransferase. Extensive seq...

journal_title：Biochemical and biophysical research communications

authors： Barra D,Martini F,Angelaccio S,Bossa F,Gavilanes F,Peterson D,Bullis B,Schirch L

更新日期：1983-11-15 00:00:00

abstract：:Rat foetal hepatocytes in primary cultures were used as a model for the study of malic enzyme gene expression. Carbohydrates and glycolytic metabolites produced the precocious induction of the malic enzyme in foetal hepatocytes cultured in the absence of serum and hormones. Palmitate prevented this induction. Insulin ...

journal_title：Biochemical and biophysical research communications

authors： Fabregat I,Lorenzo M,Benito M

更新日期：1989-06-30 00:00:00

abstract：:NADPH oxidases (NOX) - derived reactive oxygen species (ROS) contribute to oxidative injury in hypoxia-induced pulmonary arterial hypertension. This study aims to evaluate the status of NOX in endothelial progenitor cells (EPCs) under hypoxic condition and to determine whether NOX inhibitors could attenuate hypoxia-in...

journal_title：Biochemical and biophysical research communications

authors： Liu B,Ren KD,Peng JJ,Li T,Luo XJ,Fan C,Yang JF,Peng J

更新日期：2017-01-22 00:00:00

abstract：:Corneal epithelial stem cells are believed to reside in the basal layer of the limbal epithelium, but no definitive cell surface markers have been identified. For keratinocytes, stem/progenitor cells are known to be enriched by cell surface markers, integrin alpha(6) and CD71, as a minor subpopulation which shows high...

journal_title：Biochemical and biophysical research communications

authors： Hayashi R,Yamato M,Saito T,Oshima T,Okano T,Tano Y,Nishida K

更新日期：2008-03-07 00:00:00

abstract：:Insulin-stimulated GLUT4 recruitment to the plasma membrane is impaired in insulin resistance. We recently reported that a cell permeable phosphoinositide-binding peptide induces GLUT4 recruitment as potently as insulin, but does not activate GLUT4 to initiate glucose uptake. Here we investigated whether the peptide-i...

journal_title：Biochemical and biophysical research communications

authors： Funaki M,Benincasa K,Randhawa PK

更新日期：2007-09-07 00:00:00

abstract：:Endothelial argininosuccinate synthetase 1 (ASS1) regulates the provision of l-arginine to nitric oxide synthase 3 (NOS3). Previous studies demonstrated that endothelial ASS1 expression was induced by laminar shear stress (LSS) and that this enzyme plays a role in maintaining anti-inflammatory microenvironments throug...

journal_title：Biochemical and biophysical research communications

authors： Mun GI,Boo YC

更新日期：2012-04-06 00:00:00

abstract：:Hexokinase 1 (HK1) purified from rat brain exhibits protein kinase activity, including autophosphorylation and phosphorylation of histone H2A. This protein kinase activity is observed only in the absence of the HK1 carbohydrate substrate, glucose. Analysis of the ATP-binding domains of the mammalian HK1 protein sequen...

journal_title：Biochemical and biophysical research communications

authors： Adams V,Griffin LD,Gelb BD,McCabe ER

更新日期：1991-06-28 00:00:00