Lactation suppresses diurnal rhythm of serum leptin.


:Rats consume most of their daily food intake at night; serum leptin levels and adipose tissue leptin mRNA content are elevated at night in non-lactating rats fed ad libitum. Lactation induces massive hyperphagia with most food still consumed at night, but the nocturnal increase in leptin secretion was not observed in lactating rats. Thus the link between nocturnal food intake and increased serum leptin is broken during lactation and the hypoleptinaemia may be an important factor promoting the hyperphagia of lactation.


Pickavance L,Tadayyon M,Williams G,Vernon RG




Has Abstract


1998-07-09 00:00:00














  • An EGF-like peptide sequence from Dictyostelium enhances cell motility and chemotaxis.

    abstract::Dictyostelium discoideum possesses more EGF-like (EGFL) domains than any other sequenced eukaryote. Here we show that a synthetic EGFL peptide (DdEGFL1) based upon an amino acid sequence from a cysteine-rich Dictyostelium protein, functions extracellularly to enhance random cell motility and cAMP-mediated chemotaxis i...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Huber R,O'Day DH

    更新日期:2009-02-06 00:00:00

  • Age-related changes in the ovalbumin gene of the Japanese quail.

    abstract::Northern hybridization studies showed that the level of ovalbumin mRNA decreases in the oviduct of the Japanese quail after adulthood. In order to find out if this is due to changes in the conformation of the chromatin containing the promoter region of the gene, nuclei of the oviduct of young, adult and old birds were...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Upadhyay R,Gupta S,Kanungo MS

    更新日期:1996-09-13 00:00:00

  • Secretion of insulin-like growth factor II into milk.

    abstract::125I-labeled insulin-like growth factor II (IGF-II) was infused directly into the pudic artery supplying one gland of lactating goats (n = 4). Maximum specific activity for [125I]IGF-II transferred into milk from the infused gland was reached 60 min after that in plasma and was 2.5 fold greater than in milk from the n...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Prosser CG,Fleet IR

    更新日期:1992-03-31 00:00:00

  • The novel neuropeptide Y Y(1) receptor antagonist J-104870: a potent feeding suppressant with oral bioavailability.

    abstract::Neuropeptide Y (NPY) is known to induce robust feeding through the action of NPY receptors in the hypothalamus. Among the subtypes of NPY receptors, Y(1) receptors may play a key role in feeding regulation. In the present study, we demonstrated that a novel Y(1) antagonist, J-104870, shows high selectivity and potency...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kanatani A,Kanno T,Ishihara A,Hata M,Sakuraba A,Tanaka T,Tsuchiya Y,Mase T,Fukuroda T,Fukami T,Ihara M

    更新日期:1999-12-09 00:00:00

  • Effect of STI-571 (imatinib mesylate) in combination with retinoic acid and gamma-irradiation on viability of neuroblastoma cells.

    abstract::Neuroblastoma (NB) expresses the tyrosine kinase receptors c-Kit, PDGFR-alpha and -beta-targets for STI-571. We investigated a possible combination therapy of STI-571 with retinoic acid (RA) and gamma-irradiation on NB cell viability in vitro. Expression of tyrosine kinase receptors and their ligands was examined in 6...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Rössler J,Zambrzycka I,Lagodny J,Kontny U,Niemeyer CM

    更新日期:2006-04-21 00:00:00

  • Up-regulation of ganglioside biosynthesis, functional synapse formation, and memory retention by a synthetic ceramide analog (L-PDMP).

    abstract::To address the role of brain gangliosides in synaptic activity, the ceramide analogs, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP) and its enantiomer, L-PDMP, were used to inhibit and stimulate ganglioside biosynthesis in cultured cortical neurons. Prolonged treatment with both PDMP isomers exhibi...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Inokuchi J,Mizutani A,Jimbo M,Usuki S,Yamagishi K,Mochizuki H,Muramoto K,Kobayashi K,Kuroda Y,Iwasaki K,Ohgami Y,Fujiwara M

    更新日期:1997-08-28 00:00:00

  • Characterization of a second promoter for the mouse liver/bone/kidney-type alkaline phosphatase gene: cell and tissue specific expression.

    abstract::The second leader exon and the relative promoter of the mouse liver/bone/kidney-type alkaline phosphatase gene were identified and characterized. The transcription initiation site was determined by S1 mapping analysis. The differential expression of the two alternatively spliced transcripts was assessed in cell lines ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Studer M,Terao M,Gianni M,Garattini E

    更新日期:1991-09-30 00:00:00

  • Prediction of structurally conserved regions of D-specific hydroxy acid dehydrogenases by multiple alignment with formate dehydrogenase.

    abstract::We propose a multiple alignment of the sequence of formate dehydrogenase with the D-specific 2-hydroxy acid dehydrogenases family. Structurally conserved regions are predicted for those sequences corresponding to important regions of the catalytic and the coenzyme binding domains defined from the known three-dimension...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Vinals C,Depiereux E,Feytmans E

    更新日期:1993-04-15 00:00:00

  • Biophysical characterization of the breast cancer-related BIG3-PHB2 interaction: Effect of non-conserved loop region of BIG3 on the structure and the interaction.

    abstract::Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (BIG3) interacts with and inhibits the tumor suppressor function of prohibitin-2 (PHB2), and recent in vivo studies have demonstrated that the BIG3-PHB2 interaction is a promising target for breast cancer therapy. However, little biophysical characterization ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Chigira T,Nagatoishi S,Takeda H,Yoshimaru T,Katagiri T,Tsumoto K

    更新日期:2019-10-08 00:00:00

  • Synergistic action of Wnt and LIF in maintaining pluripotency of mouse ES cells.

    abstract::Leukaemia inhibitory factor (LIF) was the first soluble factor identified as having potential to maintain the pluripotency of mouse embryonic stem (ES) cells. Recently, a second factor, Wnt, with similar activity was found. However, the relationship between these completely different signals mediating the overlapping ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Ogawa K,Nishinakamura R,Iwamatsu Y,Shimosato D,Niwa H

    更新日期:2006-04-28 00:00:00

  • Quasi-stationary concentrations of fructose-2,6-bisphosphate in the phosphofructokinase-2/fructose-2,6-bisphosphatase cycle.

    abstract::The cooperation of phosphofructokinase-2 and fructose-2,6-bisphosphatase is investigated. Experimentally derived rate laws of the kinase and bisphosphatase activities introduced into the respective differential equations permitted to describe the time evolution of fructose-2,6-bisphosphate to quasi-stationary levels. ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kretschmer M,Schellenberger W,Hofmann E

    更新日期:1985-09-16 00:00:00

  • Mutational analysis of cysteine residues within the extracellular domains of the human vasoactive intestinal peptide (VIP) 1 receptor identifies seven mutants that are defective in VIP binding.

    abstract::We have used site-directed mutagenesis to investigate the requirement of cysteine residues in the extracellular domains of the human VIP 1 receptor for binding VIP. Cys37, Cys50, Cys63, Cys72, Cys86, Cys105 and Cys122 (N-terminal extracellular domain), Cys208 and Cys215 (second extracellular loop) and Cys288 (third ex...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Gaudin P,Couvineau A,Maoret JJ,Rouyer-Fessard C,Laburthe M

    更新日期:1995-06-26 00:00:00

  • Exposure of protein kinase motifs that trigger binding of Hsp90 and Cdc37.

    abstract::Hsp90 and its co-chaperone Cdc37 are required for the activity of numerous eukaryotic protein kinases. c-Jun N-terminal kinases (JNKs) appear to be Hsp90-independent kinases, as their activity is unaffected by Hsp90 inhibition. It is currently unknown why some protein kinases are Hsp90- and Cdc37-dependent for their f...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Prince T,Matts RL

    更新日期:2005-12-23 00:00:00

  • Phosphodiesterase 4B is an effective therapeutic target in colorectal cancer.

    abstract::Identification of new therapeutic targets may improve the survival rate of patients with colorectal cancer (CRC). Recent studies have suggested that the level of phosphodiesterase 4B (PDE4B) is elevated in fatal/refractory diffuse large B-cell lymphoma (DLBCL), and therapeutic efficacy of a PDE4 inhibitor in B-cell ly...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kim DU,Kwak B,Kim SW

    更新日期:2019-01-15 00:00:00

  • Long non-coding RNA CASP5 promotes the malignant phenotypes of human glioblastoma multiforme.

    abstract:BACKGROUND:Long non-coding RNAs (lncRNAs) have been demonstrated to be intensively involved in the development of various carcinomas, including glioblastoma multiforme (GBM). However, only a few of them have been well characterized. LncRNA CASP5 have been found to be up-regulated in GBM tissues compared with normal tis...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Zhou Y,Dai W,Wang H,Pan H,Wang Q

    更新日期:2018-06-12 00:00:00

  • Amino acid sequence analysis of human S100A7 (psoriasin) by tandem mass spectrometry.

    abstract::The Ca(2+)-binding proteins regulate a number of cellular and extracellular activities and deregulations of S100 gene expression are associated with several human diseases. For example, S100A7 is upregulated in psoriatic skin, implicating a link with psoriasis, a chronic inflammatory dermatosis. We purified human S100...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Bürgisser DM,Siegenthaler G,Kuster T,Hellman U,Hunziker P,Birchler N,Heizmann CW

    更新日期:1995-12-05 00:00:00

  • Nearest neighbour algorithm for predicting protein subcellular location by combining functional domain composition and pseudo-amino acid composition.

    abstract::In this paper, based on the approach by combining the "functional domain composition" [K.C. Chou, Y. D. Cai, J. Biol. Chem. 277 (2002) 45765] and the pseudo-amino acid composition [K.C. Chou, Proteins Struct. Funct. Genet. 43 (2001) 246; Correction Proteins Struct. Funct. Genet. 2044 (2001) 2060], the Nearest Neighbou...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Cai YD,Chou KC

    更新日期:2003-05-30 00:00:00

  • Glucose-induced glutathione reduction in mitochondria is involved in the first phase of pancreatic β-cell insulin secretion.

    abstract::Glucose can acutely reduce mitochondrial glutathione redox state in rat islets. However, whether glucose-stimulated mitochondrial glutathione redox state relates to glucose-stimulated insulin secretion (GSIS) remains unknown. We used genetically encoded redox-sensitive GFPs to target the mitochondria to monitor glutat...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Liu X,Han S,Yang Y,Kang J,Wu J

    更新日期:2015-08-28 00:00:00

  • N-ethoxycarbonyl-D-phenylalanyl-L-prolyl-alpha-azalysine p-nitrophenyl ester: a novel, high selective and optimal chromogenic active site titrant for human and bovine alpha-, beta- and gamma-thrombin.

    abstract::The serine proteinase catalyzed hydrolysis of N-ethoxycarbonyl-D-phenylalanyl-L-prolyl-alpha-azalysine p- nitrophenyl ester (Eoc-D-Phe-Pro-azaLys-ONp) was investigated at pH 6.2 and 21.0 degrees C. The results are consistent with the minimum three-step catalytic mechanism. The acylation step is rate limiting for human...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Balliano G,Milla P,Giordano C,Gallina C,Coletta M,Menegatti E,Rizzi M,Bolognesi M,Ascenzi P

    更新日期:1996-08-14 00:00:00

  • The epigenetic effects of amyloid-beta(1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells.

    abstract::Amyloid-beta (Abeta) is the core component of senile plaques, which are the pathological markers for Alzheimer's disease and cerebral amyloid angiopathy. DNA methylation/demethylation plays a crucial role in gene regulation and could also be responsible for presentation of senescence. Oxidative stress, which may be in...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Chen KL,Wang SS,Yang YY,Yuan RY,Chen RM,Hu CJ

    更新日期:2009-01-02 00:00:00

  • Synemin contains the rod domain of intermediate filaments.

    abstract::We have screened a lambda gt11 cDNA library from chicken gizzard muscle with polyclonal antiserum to avian synemin. Immunopositive clones were characterized and sequenced. Computer searches identified primarily intermediate filament (IF) proteins as being homologous to the synemin clones. Synemin's sequence contained ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Becker B,Bellin RM,Sernett SW,Huiatt TW,Robson RM

    更新日期:1995-08-24 00:00:00

  • Autophagy-mediated cytoplasmic accumulation of p53 leads to apoptosis through DRAM-BAX in cadmium-exposed human proximal tubular cells.

    abstract::The tumor suppressor p53 is involved in cadmium (Cd)-induced apoptosis and autophagy. However, the regulatory mechanisms of p53 in Cd-induced kidney injury are not well established. Here, we report the role of autophagy in Cd-induced p53 induction in human proximal tubular cells (HK-2). HK-2 cells treated with Cd indu...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Lee HY,Oh SH

    更新日期:2021-01-01 00:00:00

  • Immunogenicity difference between the SARS coronavirus and the bat SARS-like coronavirus spike (S) proteins.

    abstract::SARS-like coronavirus (SL-CoV) in bats have a similar genomic organization to the human SARS-CoV. Their cognate gene products are highly conserved with the exception of the N-terminal region of the S proteins, which have only 63-64% sequence identity. The N-terminal region of coronavirus S protein is responsible for v...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Zhou P,Han Z,Wang LF,Shi Z

    更新日期:2009-09-18 00:00:00

  • Fat depot-specific differences in pref-1 gene expression and adipocyte cellularity between Wagyu and Holstein cattle.

    abstract::Preadipocyte factor-1 (pref-1) is specifically expressed in preadipocytes and acts as a gatekeeper of adipogenesis by maintaining the preadipocyte state and preventing adipocyte differentiation. We hypothesized that the breed differences of adipogenic capacity in cattle could be explained by the expression level of pr...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Yamada T,Higuchi M,Nakanishi N

    更新日期:2014-03-07 00:00:00

  • Attenuation of hepatic expression and secretion of selenoprotein P by metformin.

    abstract::High serum selenium levels have been associated epidemiologically with increased incidence of type 2 diabetes. The major fraction of total selenium in serum is represented by liver-derived selenoprotein P (SeP). This study was undertaken to test for a hypothesized effect of hyperglycemia and the antihyperglycemic drug...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Speckmann B,Sies H,Steinbrenner H

    更新日期:2009-09-11 00:00:00

  • Anabolic five subunit-type pyruvate:ferredoxin oxidoreductase from Hydrogenobacter thermophilus TK-6.

    abstract::The thermophilic, obligately chemolithoautotrophic hydrogen-oxidizing bacterium, Hydrogenobacter thermophilus TK-6, assimilates carbon dioxide via the reductive tricarboxylic acid cycle. A gene cluster, porEDABG, encoding pyruvate:ferredoxin oxidoreductase (POR), which plays a key role in this cycle, was cloned and se...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Ikeda T,Ochiai T,Morita S,Nishiyama A,Yamada E,Arai H,Ishii M,Igarashi Y

    更新日期:2006-02-03 00:00:00

  • The reconstituted 'humanized liver' in TK-NOG mice is mature and functional.

    abstract::To overcome the limitations of existing models, we developed a novel experimental in vivo platform for replacing mouse liver with functioning human liver tissue. To do this, a herpes simplex virus type 1 thymidine kinase (HSVtk) transgene was expressed within the liver of highly immunodeficient NOG mice (TK-NOG). Mous...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Hasegawa M,Kawai K,Mitsui T,Taniguchi K,Monnai M,Wakui M,Ito M,Suematsu M,Peltz G,Nakamura M,Suemizu H

    更新日期:2011-02-18 00:00:00

  • The majority of cDNA clones with strong positive signals for the interferon-induction-specific sequences resemble mitochondrial ribosomal RNA genes.

    abstract::A complementary DNA library prepared from the 12S polyadenylated RNAs extracted from interferon-induced KG-1 cells, a human myeloblast cell line, was screened for the presence of induction-specific sequences. Clones that exhibited strong positive signals were separated by hybridization criteria into nine classes. Clon...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Tsuzuki T,Nomiyama H,Setoyama C,Maeda S,Shimada K,Pestka S

    更新日期:1983-07-29 00:00:00

  • Effect of phospholipase Cbeta4 lacking in thalamic neurons on electroencephalogram.

    abstract::Activity of thalamic neurons has been shown to be modulated via type-1 metabotropic glutamate receptor (mGluR1) activation, which initiates an intracellular Ca signaling cascade involving phospholipase Cbeta4 (PLCbeta4) and leading to the activation of conventional protein kinase C (cPKC). In the present study, we inv...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kameyama M,Yamaguchi I,Ichikawa K,Sugiyama T,Hirono M,Hori H,Ikeda M,Kuwahata Y,Eguchi N,Urade Y,Yoshioka T

    更新日期:2003-04-25 00:00:00

  • Differential inhibition of telomerase activity during induction of differentiation in hematopoietic, melanoma, and glioma cells in culture.

    abstract::Accumulating evidence indicates that telomerase activity is stringently repressed in normal human somatic cells but reactivated in cancers and immortal cells, suggesting that activation of telomerase activity may play a role in carcinogenesis and immortalization. Recently, down-regulation of telomerase activity by ind...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Cheng AJ,Liao SK,Chow SE,Chen JK,Wang TC

    更新日期:1997-08-18 00:00:00