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A wheat germ-derived peptide YDWPGGRN facilitates skin wound-healing processes.

Abstract：

:Wheat germ derivatives have been shown to inhibit inflammation-related diseases. In this study, a small peptide (YDWPGGRN) isolated from wheat germ was used to study its anti-inflammatory activity and its application in skin wound healing. Both the in vitro and in vivo results clearly showed that YDWPGGRN significantly inhibited the LPS-stimulated NO, IL-1β, IL-6 and TNF-α production but promoted the release of an anti-inflammatory cytokine, IL-10. In addition, YDWPGGRN directly enhanced the proliferation and migration of HaCaT cells and L929 cells. Furthermore, the results demonstrated that YDWPGGRN was able to stimulate angiogenesis and collagen production in wound areas, consequently accelerating the skin wound-healing processes in a rat model with a full thickness dermal wound. The current findings suggest that YDWPGGRN promotes wound healing by anti-inflammatory reactions and enhances the proliferation and migration of keratinocytes and fibroblasts; therefore, it may be applicable for skin wound therapeutics.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sui H,Wang F,Weng Z,Song H,Fang Y,Tang X,Shen X

doi

10.1016/j.bbrc.2020.01.162

subject

Has Abstract

pub_date

2020-04-16 00:00:00

pages

943-950

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(20)30247-3

journal_volume

524

pub_type

杂志文章

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