Differences between some properties of acetylated and nonacetylated forms of HMG1 protein.

Abstract:

:There are data suggesting that HMG1 protein may be involved in DNA replication. Recently we have found that only the acetylated form of the protein generates tetramers, stimulates the activity of DNA polymerase alpha (EC 2.7.7.7) (with activated DNA as a template) and forms a specific complex with it. This paper compares some properties of the acetylated and nonacetylated forms of HMG1 protein and shows that it is only the acetylated form which serves as a histone assembly factor, increases the melting temperature of poly d[(A-T)] and stimulates the activity of DNA polymerase alpha when histone H1-depleted chromatin is used as a template.

authors

Dimov SI,Alexandrova EA,Beltchev BG

doi

10.1016/0006-291x(90)90883-o

subject

Has Abstract

pub_date

1990-01-30 00:00:00

pages

819-26

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(90)90883-O

journal_volume

166

pub_type

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