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Prolyl isomerase Pin1 is required sperm production by promoting mitosis progression of spermatogonial stem cells.

Abstract：

:A prolyl isomerase Pin1 deficient (Pin1-/-) male mice had severe testicular atrophy. We investigated the function of Pin1 in spermatogenesis by analyzing the Pin1-/- mice at reproductive age. Pin1-/- mice had lessαPLZF positive spermatogonia (undifferentiated spermatogonia) than wild type (WT). Nevertheless, the Pin1-/- testis contained approximately the same number of GFRα1 positive spermatogonia (SSCs in steady state) as the WT testis. Furthermore, degeneration of the spermatogenia appeared in seminiferous tubules of 10 months old Pin1-/- mouse testis, and abnormal shape GFRα1 positive spermatogonia were observed. In Pin1-/- spermatogonia, the ratio of the phospho-histone H3 positive cells (mitotic cells) in GFRα1-positive spermatogonia was higher than that of WT. These results suggest that Pin1 promotes the progression of the mitotic cell cycle of SSC in steady-state, which is required for the sperm production from SSCs.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kurita-Suzuki A,Kamo Y,Uchida C,Tanemura K,Hara K,Uchida T

doi

10.1016/j.bbrc.2018.02.090

subject

Has Abstract

pub_date

2018-02-26 00:00:00

pages

388-393

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(18)30319-X

journal_volume

497

pub_type

杂志文章

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