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Inflammatory mechanism of Chlamydia trachomatis-infected HeLa229 cells regulated by Atg5.

Abstract：

:The relation between autophagy and Chlamydia trachomatis infection remain inconclusive. In order to further understand the role of autophagy in C. trachomatis-infected cells. Atg5 silenced HeLa229 cell line was used to establish an autophagy inhibition C. trachomatis infection model. The results suggested that Atg5 served a key regulatory role in the autophagy of C. trachomatis-infected cells. Silencing Atg5 significantly inhibited the autophagy level of the infected cells. Furthermore, Atg5 knockdown led to increased secretion of proinflammatory cytokines IL-1β, IL-6, IFN-γ and TNF-α, and decreased secretion of anti-inflammatory cytokine IL-10 in C. trachomatis-infected cells after autophagy induction, which suggested the anti-inflammatory role of autophagy during chlamydia infection. This study reveals some physiological and pathological roles of autophagy during C. trachomatis infection, which would provide clues in the treatment of chronic chlamydia infection.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wang F,Zhang L,Lu X,Zhu Q,Shi T,Lu R,Yu P,Zhang H,Wang Y

doi

10.1016/j.bbrc.2019.09.132

subject

Has Abstract

pub_date

2019-11-26 00:00:00

pages

205-210

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(19)31870-4

journal_volume

520

pub_type

杂志文章

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