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Differential expression of wild-type and variant ER mRNAs by stocks of MCF-7 breast cancer cells may account for differences in estrogen responsiveness.

Abstract：

:The MCF-7 human breast cancer cell line is routinely used as a model system for the study of ER+, estrogen-responsive human breast cancer. Although most investigators have found these cells to be estrogen-responsive, there are reports that some stocks of MCF-7 cells may be either insensitive or may display decreased sensitivity to the mitogenic effects of estrogen. We report here that differences in estrogen responsiveness appear to be related to varying ratios of wild type to variant ER mRNAs. MCF-7 stocks which express a high ratio of wild type to variant ER transcripts are more responsive to the mitogenic effects of physiological concentrations of estradiol than stocks which express an elevated ratio of exon 5 deletion variant to wild type ER transcripts.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Klotz DM,Castles CG,Fuqua SA,Spriggs LL,Hill SM

doi

10.1006/bbrc.1995.1702

subject

Has Abstract

pub_date

1995-05-16 00:00:00

pages

609-15

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(85)71702-0

journal_volume

210

pub_type

杂志文章

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