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Differential subcellular localisation of two isoforms of p70 S6 protein kinase.

Abstract：

:Ribosomal protein S6 phosphorylation is stimulated by a variety of hormones and growth factors. In mammalian cells the predominant S6 kinase is a 70 kDa enzyme which exists in two forms differing only in their amino terminal region. To determine whether this difference is functionally significant we have examined the intracellular localisation of the two forms. In cells transfected with cDNA encoding the longer alpha I p70 S6 kinase, protein is found in both the cytoplasmic and nuclear compartments. In contrast, the shorter alpha II polypeptide is confined to the cytoplasm. The significance of this differential localisation is discussed with respect to the recent identification of p70 S6 kinase activity as being essential for cell-cycle progression and thus mitogenesis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Coffer PJ,Woodgett JR

doi

10.1006/bbrc.1994.1112

subject

Has Abstract

pub_date

1994-01-28 00:00:00

pages

780-6

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006291X84711120

journal_volume

198

pub_type

杂志文章

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