Trichosanthin affects HSV-1 replication in Hep-2 cells.

Abstract:

:Trichosanthin (TCS) is a type I ribosome-inactivating protein that inhibits the replication of both human immunodeficiency virus type 1 (HIV-1) and herpes simplex virus type 1 (HSV-1). The mechanism of inhibition is not clear. This investigation explored the effects of TCS on the stages of HSV-1 infection in Hep-2 cells, from attachment to release. We demonstrated that TCS reduced HSV-1 antigen and DNA content and interfered with viral replication as early as 3-15 h after infection. TCS had no effect on HSV-1 attachment, penetration or immediate-early gene expression. However, the expression of early and late genes and virion release were diminished. In summary, this study demonstrates that TCS primarily affects HSV-1 replication in Hep-2 cells during the early to late infection period.

authors

He DX,Tam SC

doi

10.1016/j.bbrc.2010.10.080

subject

Has Abstract

pub_date

2010-11-26 00:00:00

pages

670-5

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(10)01958-3

journal_volume

402

pub_type

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