当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Tri-iodothyronine preconditioning protects against liver ischemia reperfusion injury through the regulation of autophagy by the MEK/ERK/mTORC1 axis.

Tri-iodothyronine preconditioning protects against liver ischemia reperfusion injury through the regulation of autophagy by the MEK/ERK/mTORC1 axis.

Abstract：

BACKGROUND AND OBJECTIVES:The autophagy pathway has previously been suggested as an important protective factor in liver injury. The purpose of this study is to demonstrate the protective, autophagy-modulating effect of tri-iodothyronine (T3) on liver ischemia reperfusion injury. METHODS:Liver ischemia reperfusion was induced in male C57BL/6 mice after T3 administration. Liver function, histological damage, inflammatory infiltration, cytokine production, oxidative stress, antioxidant capacity, autophagy changing, and autophagy-associated intracellular signaling pathway were assessed to evaluate the impact of antecedent T3 treatment on ischemia reperfusion induced liver injury. RESULTS:After 70% liver ischemia reperfusion injury, mice that were preconditioned with appropriate T3 displayed significantly preserved liver function, less histological damage, less apoptosis, and enhanced antioxidant capacity. Further studies revealed that mice which were preconditioned with T3 before IR induction exhibited an increased level of autophagy mediated by MEK/ERK/mTORC1. CONCLUSIONS:Our results provide the first line of evidence indicating that antecedent T3 injection can provide protection for the liver against ischemia reperfusion induced injury by enhancing autophagy. Therefore, T3 preconditioning could be a potential therapeutic approach to prevent liver IR injury related to various clinical conditions.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yang J,Wang Y,Sui M,Liu F,Fu Z,Wang QX

doi

10.1016/j.bbrc.2015.10.080

subject

Has Abstract

pub_date

2015-11-27 00:00:00

pages

704-10

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(15)30779-8

journal_volume

467

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Sulfoglycolipids bind to adhesive protein amphoterin (P30) in the nervous system.

    abstract：:HNK-1 antibody reactive carbohydrate epitope carried by glycolipids and glycoproteins has been shown to be involved in cell to cell interactions. It has been proposed that the HNK-1 reactive 3-sulfoglucuronyl carbohydrate epitope in glycolipids may interact with a cell surface receptor to promote the biological respon...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)91787-q

    authors： Mohan PS,Laitinen J,Merenmies J,Rauvala H,Jungalwala FB

    更新日期：1992-01-31 00:00:00

  • Action of peptidases in brain synaptic membranes on the NH2-terminus of adrenocorticotropin using ACTH-(1-16)-NH2 as a model substrate.

    abstract：:The action of brain peptidases on NH2-terminal sequences of adrenocorticotropin was studied by incubation of ACTH-(1-16)-NH2 under different pH conditions. Profiles of metabolites and time course of product formation were obtained by HPLC analysis of the digests. Fragments of ACTH-(1-16)-NH2 were isolated and characte...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(83)80145-4

    authors： Wang XC,Burbach JP,Verhoef JC

    更新日期：1983-02-28 00:00:00

  • Acute hydroxyurea treatment reduces tubular damage following bilateral ischemia-reperfusion injury in a mouse model of sickle cell disease.

    abstract：:Ischemic injury is a primary contributor to the initiation of renal tubular epithelial cell damage in sickle cell disease (SCD). In this study, we investigated the effects of bilateral ischemia-reperfusion injury, which is a common type of acute kidney injury (AKI), in male and female genetic mouse model of SCD. Bilat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.05.116

    authors： Park F,Soni H,Pressly JD,Adebiyi A

    更新日期：2019-07-12 00:00:00

  • Dominant-negative HMGA1 blocks mu enhancer activation through a novel mechanism.

    abstract：:The immunoglobulin mu intronic enhancer is a potent B cell-specific transcriptional activator. The enhancer is activated by the appropriate combination of transcription factors, amongst which are ets and bHLH proteins. HMGA1 (formerly HMG-I(Y)) is a demonstrated co-activator of the mu enhancer. HMGA1 functions through...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2002.6672

    authors： Andreucci A,Reeves R,McCarthy KM,Nikolajczyk BS

    更新日期：2002-03-29 00:00:00

  • Parathyroid hormone-related protein is a possible autocrine growth inhibitor for lymphocytes.

    abstract：:Adult T-cell leukemia (ATL)-related cells have the ability to produce a newly-isolated calcium-regulating protein, parathyroid hormone-related protein (PTHrP). The present study revealed that lectin-stimulated normal lymphocytes produce immunoreactive (IR)-PTHrP. When the T-cell-enriched fraction was purified from nor...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)90978-v

    authors： Adachi N,Yamaguchi K,Miyake Y,Honda S,Nagasaki K,Akiyama Y,Adachi I,Abe K

    更新日期：1990-02-14 00:00:00

  • Structure and analysis of the bovine atrial natriuretic peptide precursor gene.

    abstract：:The isolation and sequence analysis of the gene encoding the bovine atrial natriuretic peptide (ANP) precursor is described. The bovine-ANP coding sequences are located on three exons which are interrupted by two intervening sequences. Comparison of the bovine, human, rat and mouse ANP gene sequences reveals a common ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90924-1

    authors： Vlasuk GP,Miller J,Bencen GH,Lewicki JA

    更新日期：1986-04-14 00:00:00

  • Molecular modeling of the human multidrug resistance protein 1 (MRP1/ABCC1).

    abstract：:Multidrug resistance protein 1 (MRP1/ABCC1) is a 190kDa member of the ATP-binding cassette (ABC) superfamily of transmembrane transporters that is clinically relevant for its ability to confer multidrug resistance by actively effluxing anticancer drugs. Knowledge of the atomic structure of MRP1 is needed to elucidate ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.10.141

    authors： DeGorter MK,Conseil G,Deeley RG,Campbell RL,Cole SP

    更新日期：2008-01-04 00:00:00

  • Identification of a prealbumin variant in the serum of a Japanese patient with familial amyloidotic polyneuropathy.

    abstract：:Serum prealbumin isolated from a Japanese patient with familial amyloidotic polyneuropathy (FAP) has been found to consist of a mixture of normal prealbumin and a prealbumin variant which contains a methionine for valine substitution at position 30. The prealbumin variant in the serum is identical to the prealbumin va...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(84)80092-3

    authors： Nakazato M,Kangawa K,Minamino N,Tawara S,Matsuo H,Araki S

    更新日期：1984-07-31 00:00:00

  • TGFβ1-induced down-regulation of microRNA-138 contributes to epithelial-mesenchymal transition in primary lung cancer cells.

    abstract：:The existence of cancer stem cells within the tumor could lead to cancer therapy resistance. TGFβ1 is considered as one of the most powerful players in the generation of CSCs through induction of epithelial-mesenchymal transition in different types of cancer including lung cancer, however, the detailed mechanisms by w...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.01.164

    authors： Zhang F,Li T,Han L,Qin P,Wu Z,Xu B,Gao Q,Song Y

    更新日期：2018-02-19 00:00:00

  • The chimeric gene linked to glucocorticoid-suppressible hyperaldosteronism encodes a fused P-450 protein possessing aldosterone synthase activity.

    abstract：:Glucocorticoid-suppressible hyperaldosteronism (GSH) is one variety of primary aldosteronism with hypertension and is inherited in an autosomal dominant mode. A recent report has indicated that GSH is caused by a gene duplication arising from unequal crossing over between the two genes, CYP11B1 and CYP11B2, encoding P...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)92286-7

    authors： Miyahara K,Kawamoto T,Mitsuuchi Y,Toda K,Imura H,Gordon RD,Shizuta Y

    更新日期：1992-12-15 00:00:00

  • Articular cartilage vesicles contain RNA.

    abstract：:Small membrane-bound extracellular organelles known as articular cartilage matrix vesicles (ACVs) participate in pathologic mineralization in osteoarthritic articular cartilage. ACVs are also present in normal cartilage, although they have no known functions other than mineralization. Recently, RNA was identified in e...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.08.038

    authors： Mitton E,Gohr CM,McNally MT,Rosenthal AK

    更新日期：2009-10-23 00:00:00

  • The 31-kDa caspase-generated cleavage product of p130Cas antagonizes the action of MyoD during myogenesis.

    abstract：:Myogenesis is regulated by the basic helix-loop-helix (bHLH) myogenic regulatory factor MyoD, which induces muscle-specific gene expression by binding to the E-box sequence as a heterodimer with ubiquitous bHLH E2A (E12/E47) proteins. Here, we report that a 31-kDa caspase-generated cleavage product of Crk-associated s...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.01.085

    authors： Jeong DE,Lee EK,Song WK,Kim W

    更新日期：2014-02-21 00:00:00

  • Requirement for non-regulated, constitutive calcium influx in macrophage survival signaling.

    abstract：:The phosphatidylinositol-3-kinase (PI3K)/AKT axis and the Nuclear Factor kappa B (NFκB) pathway play critical roles in macrophage survival. In cells other than macrophages proper operation of those two pathways requires Ca²(+) influx into the cell, but if that is the case in macrophages remains unexplored. In the pres...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.03.048

    authors： Tano JY,Vazquez G

    更新日期：2011-04-08 00:00:00

  • Identification and cloning of a second phytase gene (phyB) from Aspergillus niger (ficuum).

    abstract：:An Aspergillus niger (ficuum) genomic DNA lambda EMBL3 library was probed with a 354-bp DNA fragment obtained by polymerase chain reaction of A. niger DNA with oligonucleotides based on partial amino acid sequence of a pH 2.5 optimum acid phosphatase. A clone containing a 1605 bp segment (phyB) encoding the 479 amino ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.2008

    authors： Ehrlich KC,Montalbano BG,Mullaney EJ,Dischinger HC Jr,Ullah AH

    更新日期：1993-08-31 00:00:00

  • Inhibition of endogenous BMP in the glomerulus leads to mesangial matrix expansion.

    abstract：:Bone morphogenetic protein7 (BMP7) attenuates renal tubular and interstitial damage in a variety of experimental models. The function of BMP in the glomerulus is, however, not well understood. In the present study, we generated transgenic mice carrying cDNA for noggin, an endogenous inhibitor of BMPs, driven by the po...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.12.055

    authors： Miyazaki Y,Ueda H,Yokoo T,Utsunomiya Y,Kawamura T,Matsusaka T,Ichikawa I,Hosoya T

    更新日期：2006-02-10 00:00:00

  • Leucine enkephalin antagonizes norepinephrine-induced 45Ca++ accumulation in rat atria.

    abstract：:Exposure of rat atrial slices to 10(-5) M norepinephrine (NE) for 10 minutes increases 45Ca++ accumulation from 1.64 +/- 0.10 to 2.23 +/- 0.06 nmol/mg tissue. In the presence of leucine enkephalin (10(-8) M), NE-stimulated 45Ca++ uptake is reduced to 1.44 +/- 0.10 nmol/mg tissue. The effect of leu-enkephalin is revers...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)91233-0

    authors： Ruth JA,Cuizon JV,Eiden LE

    更新日期：1983-12-16 00:00:00

  • Genomic cloning of the human histo-blood group ABO locus.

    abstract：:A P1 phage clone containing the near complete protein coding region of the human histo-blood group ABO gene locus was isolated and characterized. The insert was estimated at approximately 41 kp, and an approximately 20 kbp BamHI fragment contained the near complete coding region as evaluated by Southern blot analysis....

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1044

    authors： Bennett EP,Steffensen R,Clausen H,Weghuis DO,van Kessel AG

    更新日期：1995-01-05 00:00:00

  • Connective tissue growth factor induces cardiac hypertrophy through Akt signaling.

    abstract：:In the process of cardiac remodeling, connective tissue growth factor (CTGF/CCN2) is secreted from cardiac myocytes. Though CTGF is well known to promote fibroblast proliferation, its pathophysiological effects in cardiac myocytes remain to be elucidated. In this study, we examined the biological effects of CTGF in ra...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.03.100

    authors： Hayata N,Fujio Y,Yamamoto Y,Iwakura T,Obana M,Takai M,Mohri T,Nonen S,Maeda M,Azuma J

    更新日期：2008-05-30 00:00:00

  • Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V.

    abstract：:The human ST2 gene has been known to encode three splice variants; namely, a soluble secreted form of ST2, a transmembrane form of ST2L, and ST2V of undetermined localization. Therefore, analysis of tissue distribution and subcellular localization of ST2V is important to elucidate functional relationships among the th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5306

    authors： Tago K,Noda T,Hayakawa M,Iwahana H,Yanagisawa K,Yashiro T,Tominaga S

    更新日期：2001-08-03 00:00:00

  • Activation of prothrombin by two subtilisin-like serine proteases from Acremonium sp.

    abstract：:Two novel subtilisin-like serine proteases (AS-E1 and -E2) that activate prothrombin have been identified in a culture of the fungus Acremonium sp. The enzymes were purified through repeated hydrophobic interaction chromatography. The N-terminal sequences of AS-E1 (34.4 kDa) and AS-E2 (32 kDa) showed high similarity t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.04.133

    authors： Liu C,Matsushita Y,Shimizu K,Makimura K,Hasumi K

    更新日期：2007-06-22 00:00:00

  • Age-related changes of Alzheimer's disease-associated proteins in cynomolgus monkey brains.

    abstract：:We characterized senile plaques (SPs) immunohistochemically in cynomolgus monkey brains and also examined age-related biochemical changes of Alzheimer's disease (AD)-associated proteins in these brains from monkeys of various ages. In the neocortex of aged monkeys (>20 years old), we found SPs but no neurofibrillary t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2003.09.012

    authors： Kimura N,Tanemura K,Nakamura S,Takashima A,Ono F,Sakakibara I,Ishii Y,Kyuwa S,Yoshikawa Y

    更新日期：2003-10-17 00:00:00

  • A novel quinazoline-based analog induces G2/M cell cycle arrest and apoptosis in human A549 lung cancer cells via a ROS-dependent mechanism.

    abstract：:6-amino-4-(4-phenoxyphenylethylamino)quinazoline (QNZ) is an excellent quinazoline-containing NF-κB inhibitor also acting as a novel anticancer agent. Considering both the medicinal significance of quinazoline scaffold and the tunable functionality of Michael acceptor-centric pharmacophores in the electrophilicity-bas...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.03.034

    authors： Shi H,Li Y,Ren X,Zhang Y,Yang Z,Qi C

    更新日期：2017-04-29 00:00:00

  • APC0576, a novel inhibitor of NF-kappaB-dependent gene activation, prevents pro-inflammatory cytokine-induced chemokine production in human endothelial cells.

    abstract：:Endothelial cells participate in the inflammatory and immune reactions. Endothelial cell activation is a recurrent phenomenon linked to the pathogenesis of diverse human diseases, such as acute and chronic inflammation and cardiovascular disorders. Pro-inflammatory cytokines (e.g., IL-1, TNF) are well-known activators...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/S0006-291X(02)00322-4

    authors： Takehana K,Konishi A,Oonuki A,Noguchi M,Fujita K,Iino Y,Kobayashi T

    更新日期：2002-05-10 00:00:00

  • Pro-fibrotic effect of oxidized LDL in cardiac myofibroblasts.

    abstract：:Inflammatory signals associated with cardiac diseases trigger trans-differentiation of cardiac fibroblasts to cardiac myofibroblasts. Cardiac myofibroblasts are the main cell type involved in the development of cardiac fibrosis, a diffuse and disproportionate accumulation of collagen in the myocardium. Although the ro...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.01.156

    authors： Villa M,Cerda-Opazo P,Jimenez-Gallegos D,Garrido-Moreno V,Chiong M,Quest AF,Toledo J,Garcia L

    更新日期：2020-04-09 00:00:00

  • Transplantation of human umbilical cord blood cells improves glycemia and glomerular hypertrophy in type 2 diabetic mice.

    abstract：:Recent in vitro and in vivo studies have shown that either animal- or human-derived embryonic stem cells can differentiate into insulin-secreting cells and lower blood glucose levels. However, studies utilizing human umbilical cord blood (HUCB) mononuclear cells to improve blood glucose levels in diabetic animals have...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.06.121

    authors： Ende N,Chen R,Reddi AS

    更新日期：2004-08-13 00:00:00

  • Proteomic investigations of human HERC2 mutants: Insights into the pathobiology of a neurodevelopmental disorder.

    abstract：:HERC2 is a giant protein with E3 ubiquitin ligase activity and other known and suspected functions. Mutations of HERC2 are implicated in the pathogenesis of various cancers and result in severe neurological conditions in Herc2-mutant mice. Recently, a pleotropic autosomal recessive HERC2-associated syndrome of intelle...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.02.149

    authors： Abraham JR,Barnard J,Wang H,Noritz GH,Yeganeh M,Buhas D,Natowicz MR

    更新日期：2019-04-30 00:00:00

  • Activation of glutathione peroxidase via Nrf1 mediates genistein's protection against oxidative endothelial cell injury.

    abstract：:Cellular actions of isoflavones may mediate the beneficial health effects associated with high soy consumption. We have investigated protection by genistein and daidzein against oxidative stress-induced endothelial injury. Genistein but not daidzein protected endothelial cells from damage induced by oxidative stress. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.05.197

    authors： Hernandez-Montes E,Pollard SE,Vauzour D,Jofre-Montseny L,Rota C,Rimbach G,Weinberg PD,Spencer JP

    更新日期：2006-08-04 00:00:00

  • High sensitivity of tubifex for ultraviolet-B.

    abstract：:Phytoplankton and zooplankton serve as major food material for primary and secondary consumers in the marine food web. Although phytoplankton are primary targets to UV radiation damaging effects, we have demonstrated that stratospheric ozone depletion will affect zooplankton to contribute to inhibition in biomass prod...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.6055

    authors： Soni AK,Joshi PC

    更新日期：1997-02-24 00:00:00

  • miR-125b-1-3p inhibits trophoblast cell invasion by targeting sphingosine-1-phosphate receptor 1 in preeclampsia.

    abstract：:Preeclampsia (PE) is the leading cause of maternal and perinatal mortality and morbidity. Understanding the molecular mechanisms underlying placentation facilitates the development of better intervention of this disease. MicroRNAs are strongly implicated in the pathogenesis of this syndrome. In current study, we found...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.09.059

    authors： Li Q,Pan Z,Wang X,Gao Z,Ren C,Yang W

    更新日期：2014-10-10 00:00:00

  • MicroRNA-185 inhibits the growth and proliferation of osteoblasts in fracture healing by targeting PTH gene through down-regulating Wnt/β -catenin axis: In an animal experiment.

    abstract：:Fracture healing is a repair process of a mechanical discontinuity loss of force transmission, and pathological mobility of bone. Increasing evidence suggests that microRNA (miRNA) could regulate chondrocyte, osteoblast, and osteoclast differentiation and function, indicating miRNA as key regulators of bone formation,...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.04.138

    authors： Yao CJ,Lv Y,Zhang CJ,Jin JX,Xu LH,Jiang J,Geng B,Li H,Xia YY,Wu M

    更新日期：2018-06-18 00:00:00