Genomic cloning of the human histo-blood group ABO locus.

abstract：:During the acute phase response, synthesis of C-reactive protein and serum amyloid A is increased. To investigate whether the enhanced synthesis of these proteins are due to stimulatory effect of inflammatory mediators such as interleukin-1 (IL-1) and interleukin-6 (IL-6) produced by macrophages and monocytes, primary...

journal_title：Biochemical and biophysical research communications

authors： Moshage HJ,Roelofs HM,van Pelt JF,Hazenberg BP,van Leeuwen MA,Limburg PC,Aarden LA,Yap SH

更新日期：1988-08-30 00:00:00

abstract：:Most in vivo studies on the conversion to insulin-producing cells with AAV carrying PDX1 gene are performed in rodents. However, there is little information regarding Adeno-associated virus (AAV) carrying PDX1 gene transduced to human liver in vivo because accidental death caused by unpredicted factors cannot be denie...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto H,Mizushima T,Ogura T,Kagawa T,Tomiyama K,Takahashi R,Yagoto M,Kawai K,Chijiwa T,Nakamura M,Suemizu H

更新日期：2016-09-23 00:00:00

abstract：:Recently, we reported that in various cell lines under conditions of deenergization of the mitochondrial membrane, the release of Ca(2+) from the endoplasmic reticulum (ER) does not produce the expected activation of store-operated calcium channels (SOCs) in the plasma membrane. In the present work, we examined the ac...

journal_title：Biochemical and biophysical research communications

authors： Wasniewska M,Karczmarewicz E,Pronicki M,Piekutowska-Abramczuk D,Zablocki K,Popowska E,Pronicka E,Duszyński J

更新日期：2001-05-11 00:00:00

abstract：:Lipoprotein lipase (LPL) catalyzes the hydrolysis of the triacylglycerol component of triacylglycerol-rich lipoproteins. There are 4 cysteine pairs that are completely conserved among LPLs of all species known. We examined the functional importance of each of the cysteine pairs in enzyme catalysis by examining LPLs pr...

journal_title：Biochemical and biophysical research communications

authors： Lo JY,Smith LC,Chan L

更新日期：1995-01-05 00:00:00

abstract：:Systemic injections of AAV vectors generally transduce to the liver more effectively than to cardiac and skeletal muscles. The short hairpin RNA (shRNA)-expressing AAV9 (shRNA-AAV9) can also reduce target gene expression in the liver, but not enough in cardiac or skeletal muscles. Higher doses of shRNA-AAV9 required f...

journal_title：Biochemical and biophysical research communications

authors： Mayra A,Tomimitsu H,Kubodera T,Kobayashi M,Piao W,Sunaga F,Hirai Y,Shimada T,Mizusawa H,Yokota T

更新日期：2011-02-11 00:00:00

abstract：:Osteoclasts play an important role in bone remodeling. The inflammatory cytokine IL-17A could modulate the RANKL-induced osteoclastogenesis by regulating the autophagic activity. It is well accepted that protective autophagy has an anti-apoptotic effect. It is necessary to elucidate whether IL-17A can influence the ap...

journal_title：Biochemical and biophysical research communications

authors： Xue Y,Liang Z,Fu X,Wang T,Xie Q,Ke D

更新日期：2019-01-22 00:00:00

abstract：:We have characterized the genomic structure of the mouse Zfp148 gene encoding Beta-Enolase Repressor Factor-1 (BERF-1), a Kruppel-like zinc finger protein involved in the transcriptional regulation of several genes, which is also termed ZBP-89, BFCOL1. The cloned Zfp148 gene spans 110 kb of genomic DNA encompassing th...

journal_title：Biochemical and biophysical research communications

authors： Feo S,Antona V,Cammarata G,Cavaleri F,Passantino R,Rubino P,Giallongo A

更新日期：2001-04-27 00:00:00

abstract：:Human thyroperoxidase (TPO) ectodomain is successively made of myeloperoxidase-, complement control protein repeat-, and epidermal growth factor-like gene modules. However, the TPO immunodominant region targeted by autoantibodies from patients with an autoimmune thyroid disease has not been mapped on the molecule. Her...

journal_title：Biochemical and biophysical research communications

authors： Blanchin S,Estienne V,Guo J,Rapoport B,McLachlan SM,Carayon P,Ruf J

更新日期：2002-08-02 00:00:00

abstract：:The effect of vitamin A on the expression of apoAI and CIII genes in intact rats was studied. In vitamin A-deficient rats, the hepatic level of apoAI mRNA was increased and enhanced by an oral administration of excess retinoic acid(RA). A similar administration to normal rats caused an increase in the apoAI mRNA level...

journal_title：Biochemical and biophysical research communications

authors： Nagasaki A,Kikuchi T,Kurata K,Masushige S,Hasegawa T,Kato S

更新日期：1994-12-30 00:00:00

abstract：:Adipocyte hypertrophy and hyperplasia have been shown to be associated with shorter telomere length, which may reflect aging, altered cell proliferation and adipose tissue (AT) dysfunction. In individuals with obesity, differences in fat distribution and AT cellular composition may contribute to obesity related metabo...

journal_title：Biochemical and biophysical research communications

authors： Lakowa N,Trieu N,Flehmig G,Lohmann T,Schön MR,Dietrich A,Zeplin PH,Langer S,Stumvoll M,Blüher M,Klöting N

更新日期：2015-02-13 00:00:00

abstract：:The bovine heart mitochondrial F1-ATPase complex exhibits an intrinsic tryptophan phosphorescence that can be used to monitor structural changes of the epsilon-subunit. The phosphorescence decay rate of F1 containing the tightly bound nucleotides increases upon addition of adenine nucleoside triphosphate in the presen...

journal_title：Biochemical and biophysical research communications

authors： Baracca A,Barogi S,Gabellieri E,Lenaz G,Solaini G

更新日期：1995-02-06 00:00:00

abstract：:Xanthomonas campestris pv. campestris (Xcc), a close relative to Pseudomonas aeruginosa, is the pathogen causing black rot in cruciferous plants. In P. aeruginosa, FleQ serves as a cognate activator of sigma54 in transcription from several sigma54-dependent promoters of flagellar genes. These P. aeruginosa promoters h...

journal_title：Biochemical and biophysical research communications

authors： Hu RM,Yang TC,Yang SH,Tseng YH

更新日期：2005-10-07 00:00:00

abstract：:Triple A syndrome is an autosomal recessive neurological disease, mimicking motor neuron disease, and is caused by mutant ALADIN, a nuclear-pore complex component. We recently discovered that the pathogenesis involved impaired nuclear import of DNA repair proteins, including DNA ligase I and the cerebellar ataxia caus...

journal_title：Biochemical and biophysical research communications

authors： Kiriyama T,Hirano M,Asai H,Ikeda M,Furiya Y,Ueno S

更新日期：2008-10-03 00:00:00

abstract：:Two types of cDNA clones of protein phosphatase 2A beta, PP-2A beta L and PP-2A beta S, were isolated from a rat testis cDNA library. PP-2A beta L was 1.8 kb in length and corresponded to the 2.0 kb mRNA that is the major species expressed in somatic tissues. PP-2A beta S was 1.3 kb in length and corresponded to the 1...

journal_title：Biochemical and biophysical research communications

authors： Sasaki K,Kitagawa Y,Shima H,Irino S,Sugimura T,Nagao M

更新日期：1990-07-16 00:00:00

abstract：:Apoptosis, a genetically regulated form of cell death with distinct biochemical and morphological features, plays a relevant physiological and pathological role in the organism, being pivotal in the maintenance of tissue development and homeostasis in the adult as well as in the regulation of immune responses. Deregul...

journal_title：Biochemical and biophysical research communications

authors： Agostini M,Tucci P,Melino G

更新日期：2011-10-28 00:00:00

abstract：:Colorectal cancer is a common cancer with metachronous distant metastases still threatening overall survival. Tumor oxygen level influences tumor radiosensitivity in relation to autophagy and apoptosis. The objective of this study is to evaluate the expression and interaction between multiple key regulators in differe...

journal_title：Biochemical and biophysical research communications

authors： Tam SY,Wu VWC,Law HKW

更新日期：2019-09-17 00:00:00

abstract：:It is found that secretion of pancreastatin and somatostatin from QGP-1N cells is regulated through muscarinic receptor-mediated activation of phosphatidylinositide hydrolysis system. In this report, whether the cAMP pathway interacts with the phosphoinositide turnover system for the secretion of pancreastatin and som...

journal_title：Biochemical and biophysical research communications

authors： Tateishi K,Funakoshi A,Kitayama N,Matsuoka Y

更新日期：1992-06-30 00:00:00

abstract：:To study the role of Rab3A in regulated secretion, recombinant Rab3A protein plus various guanine nucleotides were perfused into bovine adrenal chromaffin cells via a patch pipette, and depolarization-evoked catecholamine secretion from individual cells was measured by amperometry. Rab3A plus GTP, GDP, and GTP gamma S...

journal_title：Biochemical and biophysical research communications

authors： Lin CG,Pan CY,Kao LS

更新日期：1996-04-25 00:00:00

abstract：:Phenobarbital (PB) increases metabolic capability of hepatocytes by its ability to activate numerous genes encoding various xenochemical-metabolizing enzymes such as cytochrome P450s and specific transferases. More than 35 years since PB induction was first reported, the key nuclear receptor CAR that mediates the indu...

journal_title：Biochemical and biophysical research communications

authors： Zelko I,Negishi M

更新日期：2000-10-14 00:00:00

abstract：:Apoptosis induced in primary cultures of rat hepatocytes by transforming growth factor beta 1 (TGF-beta 1) was greatly attenuated by inhibitors (5 microM) of calpain I and calpain II, respectively. Both inhibitors prevented the TGF-beta-elicited increase of nucleosomal DNA fragments and the occurrence of DNA-breaks in...

journal_title：Biochemical and biophysical research communications

authors： Gressner AM,Lahme B,Roth S

更新日期：1997-02-13 00:00:00

abstract：:Although it's well known that protein carbonyl (PCO) and advanced glycation end-products (AGEs) levels are elevated in plasma from patients with renal dysfunction, we recently identified patients who had no renal dysfunction but possessed high levels of plasma pentosidine (PEN), which is an AGEs, and low vitamin B6 le...

journal_title：Biochemical and biophysical research communications

authors： Koike S,Kayama T,Arai M,Horiuchi Y,Kobori A,Miyashita M,Itokawa M,Ogasawara Y

更新日期：2015-11-13 00:00:00

abstract：:To characterize genes involved in megakaryocytic commitment, we compared expression profiles of bipotent cells (UT-7/c-mpl) with those of the same cells induced to differentiate towards megakaryopoiesis in the presence of TPO. Using cDNA arrays, we showed that 12 out of 2260 genes changed their expression level after ...

journal_title：Biochemical and biophysical research communications

authors： Decraene C,Garçon L,Lacout C,Sabri S,Auffray C,Vainchenker W,Duménil D,Piétu G,Svinartchuk F

更新日期：2004-05-28 00:00:00

abstract：:Previous reports have shown that 12-0-tetradecanoylphorbol-13-acetate can activate phospholipase D in human peripheral blood mononuclear cells as measured by an enzyme-catalyzed transphosphatidylation reaction (phosphatidylethanol formation). In the present study, the mononuclear cells were fractionated by two procedu...

journal_title：Biochemical and biophysical research communications

authors： Kinsky SC,Loader JE,Benedict SH

更新日期：1989-07-31 00:00:00

abstract：:The risk of terrorist attacks utilizing either nuclear or radiological weapons has raised concerns about the current lack of effective radioprotectants. Here it is demonstrated that the BH4 peptide domain of the anti-apoptotic protein Bcl-xL can be delivered to cells by covalent attachment to the TAT peptide transduct...

journal_title：Biochemical and biophysical research communications

authors： McConnell KW,Muenzer JT,Chang KC,Davis CG,McDunn JE,Coopersmith CM,Hilliard CA,Hotchkiss RS,Grigsby PW,Hunt CR

更新日期：2007-04-06 00:00:00

abstract：:Abnormally expressed long noncoding RNAs (lncRNAs) has been recognized as one of the key source in cardiac diseases. However, the role of lncRNA in doxorubicin (DOX)-induced cardiotoxicity remains largely unknown. In previous studies, we have screened some aberrantly expressed lncRNAs from an animal model for DOX-indu...

journal_title：Biochemical and biophysical research communications

authors： Li J,Li L,Li X,Wu S

更新日期：2018-09-18 00:00:00

abstract：:Aberrant overexpression of the transcription/translation factor Y-box-binding protein-1 (YBX1) is associated with non-small cell lung cancer (NSCLC) aggressiveness. Cancer stem cells (CSCs) contribute to the tumorigenesis and metastasis of NSCLC. Hitherto, the mechanism by which YBX1 regulates CSCs and metastasis in N...

journal_title：Biochemical and biophysical research communications

authors： Guo T,Kong J,Liu Y,Li Z,Xia J,Zhang Y,Zhao S,Li F,Li J,Gu C

更新日期：2017-05-20 00:00:00

abstract：:We examined exendin(9-39), an antagonist of glucagon-like peptide-1 (GLP-1) receptor (GLP-1R), as a potential probe for imaging of pancreatic beta-cells. To evaluate in vitro receptor specificity, binding assay was performed using dispersed mouse islet cells. Binding assay showed competitive inhibition of [(125)I]BH-e...

journal_title：Biochemical and biophysical research communications

authors： Mukai E,Toyoda K,Kimura H,Kawashima H,Fujimoto H,Ueda M,Temma T,Hirao K,Nagakawa K,Saji H,Inagaki N

更新日期：2009-11-20 00:00:00

abstract：:Several groups have demonstrated that induction of heme-oxygenase-1 (HO-1) could protect the myocardium against ischemic events; however, heme accumulation could lead to toxicity. The aim of the present study was to investigate the role of autophagy in heme toxicity. H9c2 cardiomyoblast cells were treated with differe...

journal_title：Biochemical and biophysical research communications

authors： Gyongyosi A,Szoke K,Fenyvesi F,Fejes Z,Debreceni IB,Nagy B Jr,Tosaki A,Lekli I

更新日期：2019-04-16 00:00:00

abstract：:Viral mRNA encoding vesicular stomatitis virus glycoprotein sequences was detected and quantitated using a DNA-hybridization dot-blot technique. This assay was employed to determine if the synthetic double-stranded polynucleotide complex of polyriboinosinic-polyribocytidylic acid would elicit viral resistance in vitro...

journal_title：Biochemical and biophysical research communications

authors： Thomson MS,Bird RC,Stringfellow DA,Rossi CR,Lauerman LH

更新日期：1991-02-28 00:00:00

abstract：:The physiologically active form of vitamin D, 1,25-dihydroxyvitamin D(3), plays an important role not only in the establishment and maintenance of calcium metabolism, but also in regulating cell growth and differentiation. Because the clinical usefulness of 1,25-dihydroxyvitamin D(3) is limited by its tendency to caus...

journal_title：Biochemical and biophysical research communications

authors： Gaschott T,Steinmeyer A,Steinhilber D,Stein J

更新日期：2002-01-11 00:00:00