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Dynamics of oxygen level-driven regulators in modulating autophagy in colorectal cancer cells.

Abstract：

:Colorectal cancer is a common cancer with metachronous distant metastases still threatening overall survival. Tumor oxygen level influences tumor radiosensitivity in relation to autophagy and apoptosis. The objective of this study is to evaluate the expression and interaction between multiple key regulators in different oxygen levels. Human colorectal adenocarcinoma HT-29 cells were cultured in 1% or 10% oxygen level and irradiated by 2 Gy with different incubation time. Autophagy key regulators, AMPK, HIFs and JNK were evaluated by Western blot. Sequential autophagy key regulator activation was observed in the order of AMPK, HIF-1α, HIF-2α and JNK. 10% oxygen level could promote autophagy with similar degree of autophagy activation as 1% oxygen level in 48-h while irradiation could slightly inhibit autophagy. The results of this study supported prior evaluation of oxygen level and autophagy regulators for improving treatment efficacy and indicated the possible directions in developing individualized radiotherapy by selective targeting of hypoxic regions.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Tam SY,Wu VWC,Law HKW

doi

10.1016/j.bbrc.2019.07.043

subject

Has Abstract

pub_date

2019-09-17 00:00:00

pages

193-200

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(19)31393-2

journal_volume

517

pub_type

杂志文章

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