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Cholecystokinin elevates cytosolic calcium in small cell lung cancer cells.

Abstract：

:The ability of cholecystokinin (CCK) to elevate intracellular Ca2+ levels in small cell lung cancer cells was investigated using the fluorescent Ca2+ indicator Fura 2. CCK-8 elevated the cytosolic Ca2+ levels in cell line NCI-H345 in a dose dependent manner. Nanomolar concentration of CCK-8 elevated cytosolic Ca2+ levels in the absence or presence of extracellular Ca2+. Potent CCK agonists such as gastrin-1 and nonsulfated CCK-8 but not inactive compounds such as CCK-27-32-NH2 elevated cytosolic Ca2+ levels. These data suggest that CCK receptors may regulate the release of Ca2+ from intracellular organelles in small cell lung cancer cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Staley J,Fiskum G,Moody TW

doi

10.1016/0006-291x(89)92180-3

subject

Has Abstract

pub_date

1989-08-30 00:00:00

pages

605-10

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)92180-3

journal_volume

163

pub_type

杂志文章

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