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Molecular cloning and sequence analysis of two novel fission yeast casein kinase-1 isoforms.

Abstract：

:The cDNAs for two casein kinase-1 homologs, hhp1 and hhp2, have been isolated from Schizosaccharomyces pombe and characterized. Their corresponding genes reside on chromosomes II and I, respectively, and encode approximately 42-46 kDa proteins that are related structurally to the HRR25 gene product of budding yeast. On the basis of multiple sequence alignment, the CK1 family appears to consist of three main branches. We predict that the branch containing the hhp genes encodes nuclear kinases involved in the regulation of DNA metabolism.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kearney PH,Ebert M,Kuret J

doi

10.1006/bbrc.1994.2172

subject

Has Abstract

pub_date

1994-08-30 00:00:00

pages

231-6

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(84)72172-3

journal_volume

203

pub_type

杂志文章

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