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Inositol 1,4,5-trisphosphate induced Ca2+ release from chloroquine-sensitive and -insensitive intracellular stores in the intraerythrocytic stage of the malaria parasite P. chabaudi.

Abstract：

:Isolated P. chabaudi parasites were permeabilized with digitonin and the function of intracellular Ca2+ stores was studied using the Ca2+ indicators arsenazo III or Fluo 3-acid in the medium. Addition of the second messenger InsP3 (5 microM) to permeabilized parasites leads to Ca2+ release into the medium, with the mean extent of release being 40 nmol Ca2+/10(8) cells. This Ca2+ release was completely abolished in the presence of heparin, an InsP3 receptor antagonist. The amount of Ca2+ released was approximately 50% reduced when InsP3 was added subsequent to the discharge of the endoplasmic reticulum (ER) Ca2+ pool with the SERCA (sarcoplasmic ER Ca2+ ATPase) inhibitors thapsigargin and tBHQ (2,5-di(ter-butyl)-1,4 benzohydroquinone). The thapsigargin- and tBHQ-sensitive pool account for 20 nmol of Ca2+/10(8) cells. If InsP3 was added after the discharge of the residual Ca2+ by addition of either the K+/H+ uncoupler nigericin or the antimalarial drug chloroquine, no further Ca2+ release was observed. This is the first report of InsP3-induced Ca2+ release in a parasite protozoa. In addition our finding that chloroquine depletes an InsP3-sensitive Ca2+ compartment, raises the possibility that the InsP3-dependent Ca2+ release from this store might be important for the regulation of growth and differentiation of the parasite.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Passos AP,Garcia CR

doi

10.1006/bbrc.1998.8338

subject

Has Abstract

pub_date

1998-04-07 00:00:00

pages

155-60

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(98)98338-3

journal_volume

245

pub_type

杂志文章

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