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Changes in autophagy proteins in a rat model of controlled cortical impact induced brain injury.

Abstract：

:Autophagy has been implicated in several neurodegenerative diseases and recently its role in acute brain injury has received increased interest. In our study, we investigated the profiles of autophagy-linked proteins (MAP-LC3 (Atg8), beclin-1 (Atg6) and the beclin-1-binding protein, bcl-2, following controlled cortical impact injury in rats--a model for moderate-to-severe traumatic brain injury. We observed significant increases in the levels of the processed form of LC3 (LC3-II) in the ipsilateral cortex 2h to 2 days after injury when compared to sham. Furthermore, the beclin-1/bcl-2 ratio in the ipsilateral cortex was found to have increased from 1 and 2 days after injury. Since both of these changes are established autophagy-enabling events, and, based on these data, we propose that autophagy, plays a role in the manifestation of cell injury following brain trauma.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sadasivan S,Dunn WA Jr,Hayes RL,Wang KK

doi

10.1016/j.bbrc.2008.05.031

subject

Has Abstract

pub_date

2008-09-05 00:00:00

pages

478-81

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)00937-6

journal_volume

373

pub_type

杂志文章

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