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DNA-surfactant interactions: coupled cooperativity in ligand binding leads to duplex stabilization.

Abstract：

:The cooperative nature of interaction of cationic surfactants with short oligonucleotides leading to eventual stabilization of DNA duplexes is demonstrated. At submicellar concentrations and DNA:surfactant charge ratios of 0.2 to 0.8, the association of single chain (CTAB) and double chain (DOTAP) surfactants to oligonucleotides is initiated by electrostatic interaction of cationic ligands with polyanionic DNA that aligns the surfactant molecules on the DNA template. This is followed by binding of new surfactant ligands to the initial complex, driven cooperatively by the hydrophobic forces, leading to in situ formation of surfactant-bound and bare duplexes as separate species. These exhibit independent melting behaviour characterised by double transition in thermal UV profiles, with a higher T(m) for surfactant-DNA complexes. Understanding the cooperative binding of the cationic surfactants to the DNA described here may have implications for rational design of DNA binding drugs and DNA delivery systems.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Pattarkine MV,Ganesh KN

doi

10.1006/bbrc.1999.1266

subject

Has Abstract

pub_date

1999-09-16 00:00:00

pages

41-6

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(99)91266-4

journal_volume

263

pub_type

杂志文章

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