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Cholesterol regulates cell proliferation and apoptosis of colorectal cancer by modulating miR-33a-PIM3 pathway.

Abstract：

:The relationship between colorectal cancer (CRC) and cholesterol has been confirmed for many years, but the mechanism was not very clear. miR-33a was important in cholesterol metabolism and was abnormally expressed in many tumors, thus our study hypothesized that cholesterol effect on CRC by regulating miR-33a and its target gene PIM3, and verify it by series of assay. From results of CCK8 and flow cytometry, we confirmed cholesterol can stimulate CRC cell proliferation, promote cell cycle progression and inhibit cell apoptosis. miR-33a and SREBP2 mRNA expression were inhibited by cholesterol, and when cells transfected with miR-33a mimics or inhibitor the effect of cholesterol appeared a significant difference than before. In addition, PIM3 showed up-regulation with cholesterol treatment, and it was proved to be the target gene of miR-33a by dual luciferase reporter assay, it modulated CRC cells proliferation and apoptosis by phosphorylating p27, p21 and Bad protein. Thus, it inferred that cholesterol can regulate CRC development by miR-33a-PIM3 pathway.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wang Y,Liu C,Hu L

doi

10.1016/j.bbrc.2019.02.123

subject

Has Abstract

pub_date

2019-04-09 00:00:00

pages

685-692

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(19)30324-9

journal_volume

511

pub_type

杂志文章

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