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Partial purification of 2,3-oxidosqualene-lanosterol cyclase from hog-liver. Evidence for a functional thiol residue.

Abstract：

:2,3-Oxidosqualene-lanosterol cyclase is an intrinsic microsomal protein which can be solubilized by ionic (deoxycholate) and nonionic (emulphogene) detergents with good yields. The hog-liver microsomal cyclase was purified approximately 140-fold by chromatography on DEAE-cellulose and hydroxylapatite. The partially purified enzyme was inactivated by N-ethylmaleimide, following pseudo-first order kinetics, indicating that a cysteine residue is essential for activity.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Duriatti A,Schuber F

doi

10.1016/s0006-291x(88)80515-1

subject

Has Abstract

pub_date

1988-03-30 00:00:00

pages

1378-85

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(88)80515-1

journal_volume

151

pub_type

杂志文章

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