Attenuation of hepatic expression and secretion of selenoprotein P by metformin.

Abstract:

:High serum selenium levels have been associated epidemiologically with increased incidence of type 2 diabetes. The major fraction of total selenium in serum is represented by liver-derived selenoprotein P (SeP). This study was undertaken to test for a hypothesized effect of hyperglycemia and the antihyperglycemic drug metformin on hepatic selenoprotein P biosynthesis. Cultivation of rat hepatocytes in the presence of high glucose concentrations (25 mmol/l) resulted in increased selenoprotein P mRNA expression and secretion. Treatment with metformin dose-dependently downregulated SeP mRNA expression and secretion, and suppressed glucocorticoid-stimulated production of SeP. Moreover, metformin strongly decreased mRNA levels of selenophosphate synthetase 2 (SPS-2), an enzyme essential for selenoprotein biosynthesis. Taken together, these results indicate an influence of metformin on selenium metabolism in hepatocytes. As selenoprotein P is the major transport form of selenium, metformin treatment may thereby diminish selenium supply to extrahepatic tissues.

authors

Speckmann B,Sies H,Steinbrenner H

doi

10.1016/j.bbrc.2009.06.143

subject

Has Abstract

pub_date

2009-09-11 00:00:00

pages

158-63

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(09)01313-8

journal_volume

387

pub_type

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