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Coordinated induction of two unrelated glucose-regulated protein genes by a calcium ionophore: human BiP/GRP78 and GAPDH.

Abstract：

:The induction of human BiP/GRP78 and GAPDH protein genes by the calcium ionophore A23187 was determined. Steady-state levels of mRNA for both the glucose starvation-responsive BiP/GRP78 gene and the glucose-responsive GAPDH gene were dramatically induced in a variety of human cells. There is a homologous palindromatic sequence GCCGTTAACGGC in the active promoter region of the two genes that is known to be required for the induction of mammalian BiP/GRP78 by A23187. The evidence confirms in general the function of this element in the regulation of calcium-associated gene activity.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Chao CC,Yam WC,Lin-Chao S

doi

10.1016/0006-291x(90)91411-k

subject

Has Abstract

pub_date

1990-08-31 00:00:00

pages

431-8

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(90)91411-K

journal_volume

171

pub_type

杂志文章

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