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Protein half-lives of calmodulin and the plasma membrane Ca-ATPase in rat brain.

Abstract：

:We report the half-lives for two proteins involved in the regulation of intracellular calcium in the brain: the plasma membrane Ca-ATPase and its regulatory protein, calmodulin. [14C]-labeled leucine was injected into seven month old adult Fischer 344 rats and the time-dependent appearance and loss of radioactivity was monitored in both the serum and proteins from the brains of rats sacrificed from 4 hours to 13 days after injection. Experimental data obtained for calmodulin and the plasma membrane Ca-ATPase are best described by theoretical curves accounting for leucine reutilization that assume apparent half-lives of 18 (+/-2) hours and 12 (+/-1) days, respectively.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ferrington DA,Chen X,Krainev AG,Michaelis EK,Bigelow DJ

doi

10.1006/bbrc.1997.7105

subject

Has Abstract

pub_date

1997-08-08 00:00:00

pages

163-5

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(97)97105-9

journal_volume

237

pub_type

杂志文章

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