当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Key amino acids for differential coupling of alpha1-adrenergic receptor subtypes to Gs.

Key amino acids for differential coupling of alpha1-adrenergic receptor subtypes to Gs.

Abstract：

:We have established that differing effects of alpha1-adrenergic receptor (AR) subtypes on cell proliferation are due to differential coupling to the Gs/cAMP pathway; thus, both alpha1A- and alpha1B-ARs couple to Gs, while alpha1D-AR does not. To identify the region responsible for this difference in subtype-specific Gs coupling, we constructed a series of chimeric and a set of point-mutated human alpha1A- and alpha1D-ARs, and examined their signaling ability. Here, we show that the amino acid residues Thr 136 and Val138 in the intracellular loop II of the human alpha1A-AR are intimately involved with Gs coupling.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Shinoura H,Shibata K,Hirasawa A,Tanoue A,Hashimoto K,Tsujimoto G

doi

10.1016/s0006-291x(02)02589-5

subject

Has Abstract

pub_date

2002-11-22 00:00:00

pages

142-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006291X02025895

journal_volume

299

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Chlamydia trachomatis plasmid-encoded protein pORF5 activates unfolded protein response to induce autophagy via MAPK/ERK signaling pathway.

    abstract：:Chlamydia trachomatis (C. trachomatis) is an obligate intracellular organism that depends on nutrients from the host cell for their replication and proliferation. Therefore, the interaction between this pathogen and host induces sustained endoplasmic reticulum (ER) stress in the infected cells. Unfolded protein respon...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.04.117

    authors： Wen Y,Luo F,Zhao Y,Su S,Shu M,Li Z

    更新日期：2020-06-30 00:00:00

  • Identification of human plasma C1 inhibitor as a target protein for staphylococcal superantigen-like protein 5 (SSL5).

    abstract：:The family of staphylococcal superantigen-like proteins (SSLs) have a structure similar to bacterial superantigens but exhibit no superantigenic activity. These exoproteins have recently been shown to disturb the host immune defense system. One family member, SSL5, was reported to bind to human leukocyte P-selectin gl...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.12.026

    authors： Oku T,Kurisaka C,Ando Y,Tsuji T

    更新日期：2019-01-22 00:00:00

  • Regulation of procaspase-2 by glucocorticoid modulatory element-binding protein 1 through the interaction with caspase recruitment domain.

    abstract：:Caspases are the primary executioners of apoptosis. Although procaspases believe to exist as inactive forms in cells, the detailed regulatory system remains unclear. Here we show that glucocorticoid modulatory element-binding protein 1 (GMEB1) is capable of binding to the prodomain of caspase-2. We found that this mol...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.10.145

    authors： Tsuruma K,Nakagawa T,Shirakura H,Hayashi N,Uehara T,Nomura Y

    更新日期：2004-12-24 00:00:00

  • Rat kidney microsomes convert 25-hydroxyvitamin D3 to an unidentified metabolite.

    abstract：:Kidney microsomes from vitamin D-deficient rats and from thyroparathyroidectomized rats converted 25-hydroxyvitamin D3 to an unidentified metabolite. The addition of the cytosolic fraction enhanced microsomal synthesis of this metabolite two-fold. The kinetics of the conversion in the presence of the cytosolic fractio...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)91027-6

    authors： Thierry-Palmer M,Gray TK,Williams ME,Talmage RV

    更新日期：1983-02-10 00:00:00

  • Role of voltage-sensitive calcium channels in [Ca2+]i and secretory responses to activators of protein kinase C in pituitary gonadotrophs.

    abstract：:The gonadotropin secretory response of anterior pituitary cells to phorbol esters includes both extracellular Ca2(+)-dependent and -independent components (Stojilković et al, 1988; J. Biol. Chem. 263, 17301-17306, 1988). In cultured pituitary cells, measurements of [Ca2+]i using Fura-2 and of LH release during cell pe...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)91282-w

    authors： Izumi S,Stojilković SS,Iida T,Krsmanović LZ,Omeljaniuk RJ,Catt KJ

    更新日期：1990-07-16 00:00:00

  • A novel apoptotic pathway as defined by lectin cellular initiation.

    abstract：:In this study of lectin-induced apoptosis we found that wheat germ agglutinin (WGA) initiated an accelerated type of programmed cell death developing after only 30 min of incubation with tumor cells. To analyze possible mechanisms, studies were focused using the WGA lectin whose carbohydrate specificity is well define...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.02.043

    authors： Gastman B,Wang K,Han J,Zhu ZY,Huang X,Wang GQ,Rabinowich H,Gorelik E

    更新日期：2004-03-26 00:00:00

  • The novel extremely psychrophilic luciferase from Metridia longa: Properties of a high-purity protein produced in insect cells.

    abstract：:The bright bioluminescence of copepod Metridia longa is conditioned by a small secreted coelenterazine-dependent luciferase (MLuc). To date, three isoforms of MLuc differing in length, sequences, and some properties were cloned and successfully applied as high sensitive bioluminescent reporters. In this work, we repor...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.12.067

    authors： Larionova MD,Markova SV,Vysotski ES

    更新日期：2017-01-29 00:00:00

  • Calmodulin regulation of cholinergic muscarinic receptor: effects of calcium and phosphorylating states.

    abstract：:Calmodulin (CaM) regulation of cholinergic muscarinic receptor was investigated using synaptic membrane isolated from rat brains and [3H]-QNB as a binding ligand. CaM exerts a biphasic effect on receptor binding showing both a Ca2+-dependent receptor loss and an increase depending on the state of membrane phosphorylat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91263-x

    authors： Ho AK,Wang JH

    更新日期：1985-12-31 00:00:00

  • Tumor necrosis factor-alpha increased the integrin alpha 2 beta 1 expression and cell attachment to type I collagen in human dermal fibroblasts.

    abstract：:Cell adhesion molecules of human dermal fibroblasts play an important role in the processes of wound healing. The effects of tumor necrosis factor- alpha (TNF) on the expression of integrin beta 1 subfamily in human dermal fibroblasts were examined. TNF preferentially induced the expression of alpha 2 beta 1 integrins...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1411

    authors： Ezoe K,Horikoshi T

    更新日期：1993-04-15 00:00:00

  • 1,2-Naphthoquinone disrupts the function of cAMP response element-binding protein through covalent modification.

    abstract：:1,2-Naphthoquinone (1,2-NQ) is an atmospheric contaminant with electrophilic properties that allow it to react readily with protein thiol groups such as those found on the cAMP response element-binding protein (CREB), a transcription factor with conserved cysteine residues that regulate DNA binding. In the present stu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.07.024

    authors： Endo A,Sumi D,Kumagai Y

    更新日期：2007-09-14 00:00:00

  • Ligand-induced functions of the epidermal growth factor receptor require the positively charged region asymmetrically distributed across plasma membrane.

    abstract：:Many plasma membrane proteins, including the epidermal growth factor (EGF) receptor, possess basic regions on the cytoplasmic surface of the membrane. To examine the function of these positively charged regions, we constructed mutated EGF receptor genes lacking this region by substitution of the basic amino acid resid...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)80024-5

    authors： Yamane K,Toyoshima C,Nishimura S

    更新日期：1992-05-15 00:00:00

  • The ionic liquid 1-octyl-3-methylimidazolium (M8OI) is an activator of the human estrogen receptor alpha.

    abstract：:Recent environmental sampling around a landfill site in the UK demonstrated that unidentified xenoestrogens were present at higher levels than control sites; that these xenoestrogens were capable of super-activating (resisting ligand-dependent antagonism) the murine variant 2 ERβ and that the ionic liquid 1-octyl-3-me...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.08.008

    authors： Leitch AC,Lakey AF,Hotham WE,Agius L,Kass GEN,Blain PG,Wright MC

    更新日期：2018-09-10 00:00:00

  • Oligomerization of an archaeal group II chaperonin is mediated by N-terminal salt bridges.

    abstract：:Group II chaperonins (Cpns) are essential mediators of cellular protein folding in eukaryotes and archaea. They consist of two back-to-back rings forming symmetrical cavities in which non-native substrates undergo appropriate folding, but the primary structural basis for the double ring formation remains unclear. To a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.08.112

    authors： Luo H,Zhang P,Robb FT

    更新日期：2011-09-23 00:00:00

  • Proteolytic cleavages in alpha 1-antitrypsin and microheterogeneity.

    abstract：:Antitrypsin was resolved into two pools by ion-exchange chromatography. Pool 2 contained three anodal isoinhibitors and an N-terminal sequence identical with the one found by others. Pool 1 contained, in addition to the anodal ones two cathodal isoinhibitors as well. The sequencing data of Pool 1 indicate that the cat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91664-x

    authors： Hercz A

    更新日期：1985-04-16 00:00:00

  • Ayanin diacetate-induced cell death is amplified by TRAIL in human leukemia cells.

    abstract：:Here we demonstrate that the semi-synthetic flavonoid ayanin diacetate induces cell death selectively in leukemia cells without affecting the proliferation of normal lymphocytes. Incubation of human leukemia cells with ayanin diacetate induced G(2)-M phase cell cycle arrest and apoptosis which was prevented by the non...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.10.017

    authors： Marrero MT,Estévez S,Negrín G,Quintana J,López M,Pérez FJ,Triana J,León F,Estévez F

    更新日期：2012-11-09 00:00:00

  • Expression of peroxisome proliferator activated receptor mRNA in normal and tumorigenic rodent mammary glands.

    abstract：:The peroxisome proliferator activated receptors (PPARs) alpha, beta/delta, and gamma are novel nuclear hormone receptors activated by long chain fatty acids and synthetic ligands and which regulate lipid metabolism. Recent studies have detected PPARgamma mRNA in human mammary tumor cell lines. The current study examin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.9858

    authors： Gimble JM,Pighetti GM,Lerner MR,Wu X,Lightfoot SA,Brackett DJ,Darcy K,Hollingsworth AB

    更新日期：1998-12-30 00:00:00

  • Articular cartilage vesicles contain RNA.

    abstract：:Small membrane-bound extracellular organelles known as articular cartilage matrix vesicles (ACVs) participate in pathologic mineralization in osteoarthritic articular cartilage. ACVs are also present in normal cartilage, although they have no known functions other than mineralization. Recently, RNA was identified in e...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.08.038

    authors： Mitton E,Gohr CM,McNally MT,Rosenthal AK

    更新日期：2009-10-23 00:00:00

  • Adipose tissue-deprived stem cells acquire cementoblast features treated with dental follicle cell conditioned medium containing dentin non-collagenous proteins in vitro.

    abstract：:Adipose tissue-derived stem cells (ADSCs), which are easily harvested and show excellent pluripotency potential, have generated considerable interest in regenerative medicine. In this study, the differentiation of ADSCs was assessed after treatment with dental follicle cell conditioned medium (DFCCM) containing dentin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.05.067

    authors： Wen X,Nie X,Zhang L,Liu L,Deng M

    更新日期：2011-06-10 00:00:00

  • MTA2 promotes HCC progression through repressing FRMD6, a key upstream component of hippo signaling pathway.

    abstract：:Discerning oncogenic drivers from passengers remains a major effort in understanding of the essence of the initiation and development of hepatocellular carcinoma (HCC), the most common primary liver malignancy and the third leading cause of cancer mortality worldwide. Here we report that MTA2, Metastasis Associated 1 ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.05.025

    authors： Guan C,Chang Z,Gu X,Liu R

    更新日期：2019-07-12 00:00:00

  • Down-regulated expression of exocytotic proteins in pancreatic islets of diabetic GK rats.

    abstract：:Exocytosis is regulated by exocytotic proteins, which are present in insulin-secreting beta-cells and play regulatory roles in insulin secretion. Non-insulin dependent diabetes mellitus (type 2 diabetes) is a disease characterized by impaired insulin secretion and insulin resistance. Exocytotic protein immunoreactivit...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2002.6555

    authors： Zhang W,Khan A,Ostenson CG,Berggren PO,Efendic S,Meister B

    更新日期：2002-03-08 00:00:00

  • The structure of SecB/OmpA as visualized by electron microscopy: The mature region of the precursor protein binds asymmetrically to SecB.

    abstract：:SecB, a molecular chaperone in Escherichia coli, binds a subset of precursor proteins that are exported across the plasma membrane via the Sec pathway. Previous studies showed that SecB bound directly to the mature region rather than to the signal sequence of the precursor protein. To determine the binding pattern of ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.02.062

    authors： Tang Y,Pan X,Tai PC,Sui SF

    更新日期：2010-03-19 00:00:00

  • Characterisation of the NUCKS gene on human chromosome 1q32.1 and the presence of a homologous gene in different species.

    abstract：:The NUCKS gene is located on human chromosome 1q32.1 and consists of seven exons and six introns. The gene lacks a TATA box but contains two Inr elements, two GC boxes, and one consensus-binding site for E2F-1. NUCKS is expressed in all human adult and foetal tissues investigated, and has all the features of being a h...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.08.153

    authors： Grundt K,Haga IV,Aleporou-Marinou V,Drosos Y,Wanvik B,Østvold AC

    更新日期：2004-10-22 00:00:00

  • A regulatory role of Kruppel-like factor 4 in endothelial argininosuccinate synthetase 1 expression in response to laminar shear stress.

    abstract：:Endothelial argininosuccinate synthetase 1 (ASS1) regulates the provision of l-arginine to nitric oxide synthase 3 (NOS3). Previous studies demonstrated that endothelial ASS1 expression was induced by laminar shear stress (LSS) and that this enzyme plays a role in maintaining anti-inflammatory microenvironments throug...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.03.016

    authors： Mun GI,Boo YC

    更新日期：2012-04-06 00:00:00

  • Leucine zipper domain of HIV-1 gp41 interacted specifically with alpha-catenin.

    abstract：:Interactions between viral and cellular proteins could explain the molecular mechanisms behind the viral life cycle of HIV-1. The envelope protein gp41 of HIV-1 specifically interacted with alpha-catenin, not with beta-catenin. This interaction was shown by in vitro protein assay and in vivo transfected cell systems. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2002.6583

    authors： Kim JT,Kim EM,Lee KH,Choi JE,Jhun BH,Kim JW

    更新日期：2002-03-15 00:00:00

  • Endothelial-specific deletion of Brahma-related gene 1 (BRG1) assuages unilateral ureteral obstruction induced renal injury in mice.

    abstract：:Renal homeostasis is regulated by the interplay among different cell types in the kidneys including endothelial cells. In the present study we investigated the phenotypic regulation of endothelial cells by BRG1, a chromatin remodeling protein, in a mouse model of obstructive nephropathy (ON). We report that endothelia...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.07.077

    authors： Liu L,Mao L,Xu Y,Wu X

    更新日期：2019-09-17 00:00:00

  • Connective tissue growth factor induces cardiac hypertrophy through Akt signaling.

    abstract：:In the process of cardiac remodeling, connective tissue growth factor (CTGF/CCN2) is secreted from cardiac myocytes. Though CTGF is well known to promote fibroblast proliferation, its pathophysiological effects in cardiac myocytes remain to be elucidated. In this study, we examined the biological effects of CTGF in ra...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.03.100

    authors： Hayata N,Fujio Y,Yamamoto Y,Iwakura T,Obana M,Takai M,Mohri T,Nonen S,Maeda M,Azuma J

    更新日期：2008-05-30 00:00:00

  • Interleukin-1 impairs both vascular contraction and relaxation in rabbit isolated aorta.

    abstract：:Incubation of rabbit aortic rings with interleukin-1 (100 U/ml) in vitro led to a depressed contractile response to norepinephrine, whether the endothelium was present or not. In both cases norepinephrine-induced contraction was restored in the presence of NG-methyl-L-arginine (300 microM), an inhibitor of nitric oxid...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)91793-p

    authors： Robert R,Chapelain B,Jean T,Néliat G

    更新日期：1992-01-31 00:00:00

  • Modulation of rat polymorphonuclear leukocyte 5-lipoxygenase activity by 5-HPETE and NADH-dependent flavin inhibition.

    abstract：:The effect of nicotinamide and flavin coenzymes on the 5-lipoxygenase activity has been determined in cell-free extracts from rat polymorphonuclear leukocytes. 5-lipoxygenase was assayed in the presence of 5-hydroperoxyeicosatetraenoic acid (5-HPETE), which caused a 3 to 4-fold stimulation in the maximal conversion of...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80206-6

    authors： Riendeau D,Leblanc Y

    更新日期：1986-12-15 00:00:00

  • Involvement of Mst1 in tumor necrosis factor-alpha-induced apoptosis of endothelial cells.

    abstract：:Mammalian sterile 20-kinase 1 (Mst1), a member of the sterile-20 family protein kinase, plays an important role in the induction of apoptosis. However, little is know about the physiological activator of Mst1 and the role of Mst1 in endothelial cells (ECs). We examined whether Mst1 is involved in the tumor necrosis fa...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.12.173

    authors： Ohtsubo H,Ichiki T,Imayama I,Ono H,Fukuyama K,Hashiguchi Y,Sadoshima J,Sunagawa K

    更新日期：2008-03-07 00:00:00

  • NADH-ferric reductase activity associated with dihydropteridine reductase.

    abstract：:In mammals dietary ferric iron is reduced to ferrous iron for more efficient absorption by the intestine. Analysis of a pig duodenal membrane fraction revealed two NADH-dependent ferric reductase activities, one associated with a b-type cytochrome and the other not. Purification and characterization of the non-cytochr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.2708

    authors： Lee PL,Halloran C,Cross AR,Beutler E

    更新日期：2000-05-19 00:00:00