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Ayanin diacetate-induced cell death is amplified by TRAIL in human leukemia cells.

Abstract：

:Here we demonstrate that the semi-synthetic flavonoid ayanin diacetate induces cell death selectively in leukemia cells without affecting the proliferation of normal lymphocytes. Incubation of human leukemia cells with ayanin diacetate induced G(2)-M phase cell cycle arrest and apoptosis which was prevented by the non-specific caspase inhibitor z-VAD-fmk and reduced by the overexpression of Bcl-x(L). Ayanin diacetate-induced cell death was found to be associated with: (i) loss of inner mitochondrial membrane potential, (ii) the release of cytochrome c, (iii) the activation of multiple caspases, (iv) cleavage of poly(ADP-ribose) polymerase and (v) the up-regulation of death receptors for TRAIL, DR4 and DR5. Moreover, the combined treatment with ayanin diacetate and TRAIL amplified cell death, compared to single treatments. These results provide a basis for further exploring the potential applications of this combination for the treatment of cancer.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Marrero MT,Estévez S,Negrín G,Quintana J,López M,Pérez FJ,Triana J,León F,Estévez F

doi

10.1016/j.bbrc.2012.10.017

subject

Has Abstract

pub_date

2012-11-09 00:00:00

pages

116-20

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(12)01954-7

journal_volume

428

pub_type

杂志文章

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