Histamine-induced phosphoinositide metabolism in cultured human umbilical vein endothelial cells. Association with thromboxane and prostacyclin release.

abstract：:We cloned two novel types of TEA domain-containing transcription factor (ETFR-1 and -2) cDNAs. Amino acid sequences deduced for ETFR-1 and -2 as well as those of other known proteins of the same family, TEF-1 and ETF, exhibited significant identity (63-75% overall) to each other not only in the TEA DNA binding domain ...

journal_title：Biochemical and biophysical research communications

authors： Yasunami M,Suzuki K,Ohkubo H

更新日期：1996-11-12 00:00:00

abstract：:We initiated the present work as part of an effort to identify and characterize genes from the EST2-HMG14 region from human chromosome 21 potentially responsible for some of the Down syndrome (DS) features. Genomic sample sequencing with cosmid clone A1047 located in the ETS2-HMG14 region of chromosome 21 has led to t...

journal_title：Biochemical and biophysical research communications

authors： Vidal-Taboada JM,Sanz S,Egeo A,Scartezzini P,Oliva R

更新日期：1998-09-29 00:00:00

abstract：:Obesity continues to be one of the most prominent public health dilemmas in the world. The complex interaction among the varied causes of obesity makes it a particularly challenging problem to address. While typical high-fat purified diets successfully induce weight gain in rodents, we have described a more robust mod...

journal_title：Biochemical and biophysical research communications

authors： Johnson AR,Wilkerson MD,Sampey BP,Troester MA,Hayes DN,Makowski L

更新日期：2016-04-29 00:00:00

abstract：:The bromodomain and extraterminal (BET) domain family proteins are epigenetic modulators involved in the reading of acetylated lysine residues. The first BET protein inhibitor to be identified, (+)-JQ1, a thienotriazolo-1, 4-diazapine, binds selectively to the acetyl lysine-binding pocket of BET proteins. We evaluated...

journal_title：Biochemical and biophysical research communications

authors： Goupille O,Penglong T,Kadri Z,Granger-Locatelli M,Fucharoen S,Maouche-Chrétien L,Prost S,Leboulch P,Chrétien S

更新日期：2016-04-15 00:00:00

abstract：:We identified human decapping enzyme 2 (hDCP2) as a binding protein with Ro52, being colocalized in processing bodies (p-bodies). We also showed that the N-terminus and C-terminus of Ro52 bound to hDCP2. Moreover, Ro52 enhanced decapping activity of hDCP2 in a dose-dependent manner. Our data support the novel notion o...

journal_title：Biochemical and biophysical research communications

authors： Yamochi T,Ohnuma K,Hosono O,Tanaka H,Kanai Y,Morimoto C

更新日期：2008-05-23 00:00:00

abstract：:Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that encodes a small conductance cAMP-activated chloride ion channel. In the CF pancreatic duct, mutations in CFTR cause a reduction in bicarbonate secretion. This is thought to result from CFTR operating...

journal_title：Biochemical and biophysical research communications

authors： Hyde K,Harrison D,Hollingsworth MA,Harris A

更新日期：1999-09-24 00:00:00

abstract：:The binding of four potent antimitotic agents, rhizoxin (RZX), phomopsin A (PMS-A), ansamitocin P-3 (ASMP-3), and vinblastine (VLB), to tubulins from RZX-sensitive and -resistant strains of Aspergillus nidulans, Schizosaccharomyces pombe, and Saccharomyces cerevisiae was investigated. Mycelial extracts to which RZX co...

journal_title：Biochemical and biophysical research communications

authors： Li Y,Kobayashi H,Hashimoto Y,Iwasaki S

更新日期：1992-09-16 00:00:00

abstract：:TAp63 belongs to the p53-tumour suppressor family and is capable of transactivating a set of target genes to induce cell cycle arrest and apoptosis. We showed that treatment of cancer cells with chemo-therapeutic drugs or the histone deacetylase (HDAC) inhibitor Trichostatin A (TSA) results in induction of TAp63 expre...

journal_title：Biochemical and biophysical research communications

authors： Sayan BS,Yang AL,Conforti F,Bernardini S,Tucci P,Vasa-Nicotera M,Knight RA,Melino G

更新日期：2010-01-22 00:00:00

abstract：:Normal human fibroblasts stop dividing after a limited number of cell divisions termed cellular senescence. Telomere shortening has been shown to be the main factor that causes cellular senescence, however, the molecular mechanism of how telomere shortening causes cellular senescence is unclear. Here we analyze the re...

journal_title：Biochemical and biophysical research communications

authors： Chen HL,Lu CY,Hsu YH,Lin JJ

更新日期：2004-01-16 00:00:00

abstract：:Previous studies suggested that the hydrophobic protein chargerin II, which is encoded in the A6L of mitochondrial DNA, may have a key role in the energy transduction by mitochondrial H(+)-ATP synthase because an antibody against chargerin II inhibited ATP synthesis and ATP-Pi exchange, in an energy-dependent fashion....

journal_title：Biochemical and biophysical research communications

authors： Muraguchi M,Yoshihara Y,Tunemitu T,Tani I,Higuti T

更新日期：1990-04-16 00:00:00

abstract：:Atomic force microscopy (AFM) allows to study the molecular structure of biological macromolecules with nm to A resolutions without crystallization. We show here the applicability of AFM in the quantitative analysis of the molecular mechanisms of DNA/protein interaction: (i) Protein-binding sites can be mapped over a ...

journal_title：Biochemical and biophysical research communications

authors： Nettikadan S,Tokumasu F,Takeyasu K

更新日期：1996-09-24 00:00:00

abstract：:The sequence of the complement factor C8 gamma chain shares a remarkable degree of similarity with that of alpha-1-microglobulin, a member of the alpha-2u-globulin superfamily. This superfamily comprises a diverse group of distantly related animal proteins possessing characteristic structural features and similar func...

journal_title：Biochemical and biophysical research communications

authors： Hunt LT,Elzanowski A,Barker WC

更新日期：1987-11-30 00:00:00

abstract：:Resonance energy transfer (RET) is widely used to detect proximity between biomolecules. In transparent solution the maximum donor-to-acceptor distance for RET is about 70 A. We measured the effects of metallic silver island films on RET from the intrinsic tryptophan of a protein to a bound probe as the acceptor. Thes...

journal_title：Biochemical and biophysical research communications

authors： Malicka J,Gryczynski I,Kusba J,Shen Y,Lakowicz JR

更新日期：2002-06-21 00:00:00

abstract：:A body of indirect evidence has suggested the involvement of reactive oxygen species (ROS) in tumor promotion. However, direct evidence for the involvement of in situ generated ROS in tumor promotion is lacking at present. This study provides the first in situ evidence for the involvement of ROS in stage I tumor promo...

journal_title：Biochemical and biophysical research communications

authors： Giri U,Sharma SD,Abdulla M,Athar M

更新日期：1995-04-17 00:00:00

abstract：:Hepatocyte expression of inducible nitric oxide synthase (iNOS) is initiated by the presence of pro-inflammatory cytokines, such as interleukin-1beta (IL-1). In the presence of oxidative stress, IL-1beta mediated hepatocyte iNOS expression and NO synthesis are significantly increased. To determine the underlying molec...

journal_title：Biochemical and biophysical research communications

authors： Kuo PC,Abe KY,Schroeder RA

更新日期：1997-05-19 00:00:00

abstract：:Many cell types are known to synthesize nitric oxide (NO.) from L-arginine. There appear to be at least two forms of NO. synthase: an inducible, tetrahydrobiopterin- and flavin-dependent activity exemplified by the macrophage enzyme and a constitutive, Ca+(+)-dependent activity exemplified by the endothelial cell enzy...

journal_title：Biochemical and biophysical research communications

authors： Gross SS,Stuehr DJ,Aisaka K,Jaffe EA,Levi R,Griffith OW

更新日期：1990-07-16 00:00:00

abstract：:MazF is a sequence-specific endoribonuclease or mRNA interferase, which cleaves RNA at a specific sequence. Since the expression of a specific gene or a group of specific genes can be regulated by MazF, expanding the repertoire of recognition sequences by MazF mRNA interferases is highly desirable for biotechnological...

journal_title：Biochemical and biophysical research communications

authors： Ishida Y,Inouye K,Ming O,Inouye M

更新日期：2019-10-20 00:00:00

abstract：:Transforming growth factor beta 1 (TGF beta 1) has been reported to be secreted and to act within the somatic cells of the testis. We examined whether the TGF beta 1 expression is present at mRNA and protein levels in purified rat Sertoli cells (SC), purified pachytene spermatocytes (SPC), and early spermatids (SPT) c...

journal_title：Biochemical and biophysical research communications

authors： Avallet O,Gomez E,Vigier M,Jégou B,Saez JM

更新日期：1997-09-29 00:00:00

abstract：:We have identified a 35-amino acid antibiotic cecropin secreted by an established mosquito cell line. C7-10 cells from the vector mosquito, Aedes albopictus, were incubated with heat-killed Escherichia coli, and materials secreted into the cell culture supernatant were recovered by acid precipitation. Following batch ...

journal_title：Biochemical and biophysical research communications

authors： Sun D,Eccleston ED,Fallon AM

更新日期：1998-08-19 00:00:00

abstract：:The effects of isolated platelet surface membranes on DNA synthesis and proliferation of bovine coronary artery smooth muscle cells (SMC) were studied. Platelet membranes were very potent mitogens for SMC. The potency was about 10-fold higher than the maximum effects of platelet-derived growth factor-BB (PDGF). Platel...

journal_title：Biochemical and biophysical research communications

authors： Weber AA,Zucker TP,Schrör K

更新日期：1999-06-07 00:00:00

abstract：:Ultrastructural data are presented on time-course changes in isolated rat hepatocyte suspensions exposed either to 1.2 or 1.8 mM CCl4 for up to 1 h. The subcellular changes at the lower concentration, but not the higher, are shown to closely parallel those reported to occur in rat hepatocytes following ingestion of CC...

journal_title：Biochemical and biophysical research communications

authors： Tyson CA,Story DL,Stephens RJ

更新日期：1983-07-29 00:00:00

abstract：:Voltage-gated ion channels (VGCs) mediate selective diffusion of ions across cell membranes to enable many vital cellular processes. Three-dimensional structure data are lacking for VGC proteins; hence, to better understand their function, there is a need to identify the conserved motifs using sequence analysis method...

journal_title：Biochemical and biophysical research communications

authors： Guda P,Bourne PE,Guda C

更新日期：2007-01-12 00:00:00

abstract：:Discoidin domain receptor 2 (DDR2) is a receptor tyrosine kinase that is activated by fibrillar collagens. DDR2 regulates cell proliferation, cell adhesion, migration, and extracellular matrix remodeling. The decrement of endogenous DDR2 represses osteoblastic marker gene expression and osteogenic differentiation in m...

journal_title：Biochemical and biophysical research communications

authors： Kawai I,Hisaki T,Sugiura K,Naito K,Kano K

更新日期：2012-10-26 00:00:00

abstract：:Retinoids induce marked growth inhibition and neuritic differentiation in human neuroblastoma cells. Expression patterns of nuclear retinoic acid receptors (RAR) in embryonic and adult tissues suggests that RAR subtypes alpha, beta and gamma have tissue-specific functions. We have transfected a human neuroblastoma tum...

journal_title：Biochemical and biophysical research communications

authors： Cheung B,Hocker JE,Smith SA,Reichert U,Norris MD,Haber M,Stewart BW,Marshall GM

更新日期：1996-12-04 00:00:00

abstract：:The addition of the chemotactic factor fMet-Leu-Phe to cell homogenates causes a decrease in the pertussis toxin catalyzed ADP-ribosylation of a 41 kDa protein. The fMet-Leu-Phe induced decrease is not abolished in homogenates prepared from phorbol 12-myristate 13-acetate treated neutrophils. This decreased ribosylati...

journal_title：Biochemical and biophysical research communications

authors： Matsumoto T,Molski TF,Kanaho Y,Becker EL,Sha'afi RI

更新日期：1987-03-13 00:00:00

abstract：:We examined the expression of dystrophin mRNA and the protein in the developing rat heart with polymerase chain reaction, immunoblotting and immunohistochemical analyses. Dystrophin mRNA was detectable on and after the 10th embryonic day, while the protein became detectable during the perinatal period. ...

journal_title：Biochemical and biophysical research communications

authors： Tanaka H,Ozawa E

更新日期：1990-10-30 00:00:00

abstract：:The tenascin-R (TN-R) gene encodes a multidomain extracellular matrix glycoprotein belonging to the tenascin family. It is detectable mainly in oligodendrocytes and neuronal subpopulations of the central nervous system. In this report, we describe the structure of the 5'-region of the mouse TN-R gene and characterise ...

journal_title：Biochemical and biophysical research communications

authors： Putthoff P,Akyüz N,Kutsche M,Zardi L,Borgmeyer U,Schachner M

更新日期：2003-09-05 00:00:00

abstract：:A spontaneous lymphoma was detected in mice, which was caused by a recessive autosomal mutation. The genetic basis was revealed to be a 5-bp deletion at the splicing donor site of the first intron of the FasL gene, resulting in aberrant transcripts coding for non-functional proteins. This mutation of the FasL gene cau...

journal_title：Biochemical and biophysical research communications

authors： Wang CC,Zeng Q,Hwang LA,Guo K,Li J,Liew HC,Hong W

更新日期：2006-10-13 00:00:00

abstract：:Antibodies raised against deoxyadenylate and deoxycytidylate were found to react with double stranded DNA as assessed by highly sensitive avidin-biotin microELISA. The binding was specific as it was completely inhibited by the homologous hapten. The antibodies did not react with tRNA and rRNA. These antibodies were al...

journal_title：Biochemical and biophysical research communications

authors： Vaishnav YN,Antony A

更新日期：1988-07-15 00:00:00

abstract：:The p53 tumor suppressor protein is a critical checkpoint in prevention of tumor formation, and the function of p53 is dependent on proper formation of the active tetramer. In vitro studies have shown that p53 binds DNA most efficiently as a tetramer, though inactive p53 is predicted to be monomeric in vivo. We demons...

journal_title：Biochemical and biophysical research communications

authors： Webber TM,Allen AC,Ma WK,Molloy RG,Kettelkamp CN,Dow CA,Gage MJ

更新日期：2009-06-19 00:00:00