Abstract:
:Normal human fibroblasts stop dividing after a limited number of cell divisions termed cellular senescence. Telomere shortening has been shown to be the main factor that causes cellular senescence, however, the molecular mechanism of how telomere shortening causes cellular senescence is unclear. Here we analyze the relationship between gene expressions and their chromosomal locations during cellular senescence. It appears that the expression of genes located in chromosome 4 is preferentially altered after senescence. Moreover, we identify four chromosomal loci in which gene expressions are affected by senescence. Finally, we show that there is no preferential alteration of telomere-proximal genes during cellular senescence, implying that cellular senescence is not caused by derepression of telomere-proximal genes.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Chen HL,Lu CY,Hsu YH,Lin JJdoi
10.1016/j.bbrc.2003.11.146subject
Has Abstractpub_date
2004-01-16 00:00:00pages
576-86issue
3eissn
0006-291Xissn
1090-2104pii
S0006291X03025464journal_volume
313pub_type
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