Abstract:
:In addition to its interaction at hypothalamic sites to affect feeding and energy expenditure, leptin has been shown to exhibit a proliferative response in erythropoietic cells. The functional leptin receptor is also present in pancreatic islets and we now demonstrate that a commonly used clonal insulin secreting beta-cell line, RINm5F, expresses high levels of the Ob-Rb mRNA. Leptin causes an increase in tyrosine phosphorylation of a number of intracellular proteins and a dose related (10 nM-200 nM) increase in expression of the immediate-early gene, c-fos. This precedes a leptin induced proliferative response in serum-deprived RINm5F cells, which suggests that leptin might be involved in the complex regulation of proliferation of the pancreatic beta-cell.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Islam MS,Morton NM,Hansson A,Emilsson Vdoi
10.1006/bbrc.1997.7399subject
Has Abstractpub_date
1997-09-29 00:00:00pages
851-5issue
3eissn
0006-291Xissn
1090-2104pii
S0006-291X(97)97399-Xjournal_volume
238pub_type
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