Abstract:
:There are tremendous drug candidates that suffer from insolubility in water. In the present study, it is shown that Coenzyme Q10 (CoQ10), a model water-insoluble compound, can be nanoparticulated into a water-soluble form using apolipoprotein A-I (apoA-I). Similar to the way that apoA-I forms nascent discoidal high density lipoprotein (ndHDL) particles by bordering acyl chain tails of phospholipids, CoQ10 could be enclosed into the circle of a disk made of apoA-Is. The resulting nanostructure of CoQ10 and apoA-I was water-soluble with a size of approximately 12 nm in diameter and was physically more robust than liposome. We expect that the strategy suggested in this study can be exploited to assemble nano-sized, water-soluble structures of various water-insoluble drug candidates.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Shin JY,Shin JI,Kim JS,Yang YS,Hwang Y,Yang JS,Shin D,Seo JH,Jin YS,Park YC,Hwang JS,Kweon DHdoi
10.1016/j.bbrc.2009.07.140subject
Has Abstractpub_date
2009-10-16 00:00:00pages
217-21issue
2eissn
0006-291Xissn
1090-2104pii
S0006-291X(09)01513-7journal_volume
388pub_type
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