Effects of metoclopramide on rat spleen lymphocyte proliferation.

Abstract:

:The effect of metoclopramide on proliferation of spleen lymphocytes in rats was examined. The rate of [3H]thymidine incorporation into DNA was used as an index of lymphocytes proliferation. It was shown that the incorporation of [3H]thymidine into DNA of spleen lymphocytes in the rats treated with metoclopramide was significantly higher than that in the control group. The effects of various concentrations of prolactin and metoclopramide on [3H]thymidine uptake by DNA of spleen lymphocytes was also studied in vitro. It was shown that: 1, Prolactin, at the concentration of 1 and 0.1 ng/ml significantly increased [3H]thymidine incorporation into DNA of spleen lymphocytes. Metoclopramide in all the examined concentrations also caused a significant proliferogenic effect on lymphocytes.

authors

Zerek-Melen G,Winczyk K,Kunert-Radek J,Pawlikowski M

doi

10.1016/0006-291x(90)90797-q

subject

Has Abstract

pub_date

1990-09-28 00:00:00

pages

1099-104

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(90)90797-Q

journal_volume

171

pub_type

杂志文章
  • Mouse and human SHPS-1: molecular cloning of cDNAs and chromosomal localization of genes.

    abstract::SHPS-1 (SHP substrate-1) is a glycosylated receptor-like protein with three immunoglobulin-like domains in its extracellular region and four YXX(L/V/I) motifs, potential tyrosine phosphorylation and SRC homology 2 (SH2) domain binding sites, in its cytoplasmic region. Various mitogens and cell adhesion induce tyrosine...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1996.6047

    authors: Yamao T,Matozaki T,Amano K,Matsuda Y,Takahashi N,Ochi F,Fujioka Y,Kasuga M

    更新日期:1997-02-03 00:00:00

  • Human thioredoxin reactivity-structure/function relationship.

    abstract::The reactivity of human thioredoxin (HTR) was tested in several reactions. HTR was as efficient as E. coli or plant and algal thioredoxins when assayed with E. coli ribonucleotide reductase or for the reduction of insulin. On the other hand, HTR was poorly reduced by NADPH and the E. coli flavoenzyme NADPH thioredoxin...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/s0006-291x(05)80940-4

    authors: Jacquot JP,de Lamotte F,Fontecave M,Schürmann P,Decottignies P,Miginiac-Maslow M,Wollman E

    更新日期:1990-12-31 00:00:00

  • Exercise maintains blood-brain barrier integrity during early stages of brain metastasis formation.

    abstract::Tumor cell extravasation into the brain requires passage through the blood-brain barrier, which is a highly protected microvascular environment fortified with tight junction (TJ) proteins. TJ integrity can be regulated under physiological and pathophysiological conditions. There is evidence that exercise can modulate ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2015.04.153

    authors: Wolff G,Davidson SJ,Wrobel JK,Toborek M

    更新日期:2015-08-07 00:00:00

  • Dicarbanonaborates--new inhibitors of mitochondrial L-glycerol-3-phosphate dehydrogenase.

    abstract::The inhibitory effect of mercapto- and chlorodicarbanonaborates on mitochondrial, FAD-linked, L-glycerol-3-phosphate dehydrogenase activity was tested. The mercaptodicarbanonaborate was found to be a more potent inhibitor than the chloro derivative. The Ki of mercapto- and chlorodicarbanonaborates were 0.8 M and 480 M...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1995.1724

    authors: Drahota Z,Saf P,Rauchová H,Kalous M

    更新日期:1995-05-25 00:00:00

  • Insulin-dependent phosphatidylinositol 3'-kinase activity co-precipitates with insulin receptor in human circulating mononuclear cells.

    abstract::In order to establish a working cellular model for the study of post-receptor signaling events, insulin-dependent phosphatidylinositol 3' (PtdIns 3')-kinase activity was investigated in circulating mononuclear cells from normal subjects. The p85 alpha regulatory subunit of PtdIns 3'-kinase co-precipitated with activat...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1995.1494

    authors: Renard E,Grigorescu F,Lavabre C,Kahn CR

    更新日期:1995-04-06 00:00:00

  • Ras proteins regulate multiple mitogenic pathways in A10 vascular smooth muscle cells.

    abstract::We examined the role of ras proteins in mitogenesis and proliferation of A10 smooth muscle cells. An assay was developed in which a dominant negative ras gene could be transiently expressed in vascular smooth muscle cells. As opposed to cells transfected with a control plasmid, those transfected with a dominant negati...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1994.2065

    authors: Irani K,Herzlinger S,Finkel T

    更新日期:1994-08-15 00:00:00

  • cDNA cloning, expression, and mutagenesis of a PR-10 protein SPE-16 from the seeds of Pachyrrhizus erosus.

    abstract::SPE-16 is a new 16kDa protein that has been purified from the seeds of Pachyrrhizus erosus. It's N-terminal amino acid sequence shows significant sequence homology to pathogenesis-related class 10 proteins. cDNA encoding 150 amino acids was cloned by RT-PCR and the gene sequence proved SPE-16 to be a new member of PR-...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2003.10.181

    authors: Wu F,Yan M,Li Y,Chang S,Song X,Zhou Z,Gong W

    更新日期:2003-12-19 00:00:00

  • Sequence of the signal peptide for rat liver mitochondrial aldehyde dehydrogenase.

    abstract::The cDNA coding for the signal peptide of rat liver mitochondrial aldehyde dehydrogenase was sequenced. The deduced amino acid sequence of the signal peptide was MLRAALSTARRGPRLSRLL. From this sequence an amphiphilic helix which had a high hydrophobic moment could be constructed. A comparison to the published cDNA seq...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(88)90740-1

    authors: Farrés J,Guan KL,Weiner H

    更新日期:1988-02-15 00:00:00

  • Cobalamin inhibition of HIV-1 integrase and integration of HIV-1 DNA into cellular DNA.

    abstract::Our prior studies showed that certain cobalamins inhibit productive HIV-1 infection of primary cultures of blood lymphocytes and monocytes. We demonstrate here that this antiviral activity may be mediated by an inhibition of HIV-1 integrase, an enzyme required for productive infection. Purified recombinant HIV-1 integ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1998.8629

    authors: Weinberg JB,Shugars DC,Sherman PA,Sauls DL,Fyfe JA

    更新日期:1998-05-19 00:00:00

  • Sequence homology between prokaryotic and eukaryotic forms of serine hydroxymethyltransferase.

    abstract::The sequence of tryptic and chymotryptic peptides from cytosolic and mitochondrial rabbit liver serine hydroxymethyltransferase are compared to the proposed sequence of a protein coded for by the glyA gene of Escherichia coli. The E. coli glyA gene is believed to code for serine hydroxymethyltransferase. Extensive seq...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/s0006-291x(83)80242-3

    authors: Barra D,Martini F,Angelaccio S,Bossa F,Gavilanes F,Peterson D,Bullis B,Schirch L

    更新日期:1983-11-15 00:00:00

  • A method for determining the intracellular distribution of enzymes in yeast provides no evidence for the association of hexokinase with mitochondria.

    abstract::A simple procedure based upon the principle discovered by Dürr et al. (Arch. Microbiol. (1975) 105, 319-327) was used to measure the intracellular distribution of enzymes in S. cerevisiae grown under both glucose repression and derepression. No substantial hexokinase activity was found to be associated with cellular o...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(86)90560-7

    authors: Kovác L,Nelson BD,Ernster L

    更新日期:1986-01-14 00:00:00

  • Corticotropin-releasing factor stimulates Ca2+ influx in cultured rat astrocytes.

    abstract::Corticotropin-releasing factor (CRF) increased intracellular Ca2+ concentration in single astrocytes. The effect in increasing intracellular Ca2+ was not observed in Ca2(+)-free solution. Furthermore, CRF at concentrations more than 10 nM stimulated 45Ca2+ uptake in cultured rat astrocytes. The action was blocked by a...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1994.1344

    authors: Takuma K,Matsuda T,Yoshikawa T,Kitanaka J,Gotoh M,Hayata K,Baba A

    更新日期:1994-03-30 00:00:00

  • A kinetic study of the mechanism of conversion of alpha-hydroxyheme to verdoheme while bound to heme oxygenase.

    abstract::O2-dependent reactions of the ferric and ferrous forms of alpha-hydroxyheme complexed with water-soluble rat heme oxygenase-1 were examined by rapid-scan stopped-flow measurements. Ferric alpha-hydroxyheme reacted with O2 to form ferric verdoheme with an O2-dependent rate constant of 4x10(5) M(-1) s(-1) at pH 7.4 and ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2005.08.176

    authors: Sakamoto H,Takahashi K,Higashimoto Y,Harada S,Palmer G,Noguchi M

    更新日期:2005-12-09 00:00:00

  • Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R).

    abstract::Galanin is a neuroendocrine peptide that modulates many different normal physiological effects including memory, weight, and pain perception. To better understand galanin receptor function, we cloned and characterized the galanin-1 receptor (GALN1R) gene isolated from a human P1 library. We determined that this gene c...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1997.7838

    authors: Lorimer DD,Matkowskj K,Benya RV

    更新日期:1997-12-18 00:00:00

  • Free-soluble and outer membrane vesicle-associated VacA from Helicobacter pylori: Two forms of release, a different activity.

    abstract::Helicobacter pylori releases VacA both as free-soluble and as outer membrane vesicle (OMV)-associated toxin. In this study, we investigated the amount of VacA released in each of the two forms and the role of each form in VacA-induced cell vacuolation in vitro. We found that: (1) free-soluble toxin accounted for about...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2005.09.035

    authors: Ricci V,Chiozzi V,Necchi V,Oldani A,Romano M,Solcia E,Ventura U

    更新日期:2005-11-11 00:00:00

  • Helicobacter pylori-derived Heat shock protein 60 enhances angiogenesis via a CXCR2-mediated signaling pathway.

    abstract::Helicobacter pylori is a potent carcinogen associated with gastric cancer malignancy. Recently, H. pylori Heat shock protein 60 (HpHSP60) has been reported to promote cancer development by inducing chronic inflammation and promoting tumor cell migration. This study demonstrates a role for HpHSP60 in angiogenesis, a ne...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2010.05.101

    authors: Lin CS,He PJ,Hsu WT,Wu MS,Wu CJ,Shen HW,Hwang CH,Lai YK,Tsai NM,Liao KW

    更新日期:2010-06-25 00:00:00

  • Induction of pluripotency in mammalian fibroblasts by cell fusion with mouse embryonic stem cells.

    abstract:BACKGROUND:Cell fusion is a phenomenon that is observed in various tissues in vivo, resulting in acquisition of physiological functions such as liver regeneration. Fused cells such as hybridomas have also been produced artificially in vitro. Furthermore, it has been reported that cellular reprogramming can be induced b...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2019.10.026

    authors: Imai H,Kusakabe KT,Kiso Y,Hattori S,Kai C,Ono E,Kano K

    更新日期:2020-01-01 00:00:00

  • Bacterial adhesion and growth reduction by novel rubber-derived oligomers.

    abstract::In the medical field, attached bacteria can cause infections associated with catheters, incisions, burns, and medical implants especially in immunocompromised patients. The problem is exacerbated by the fact that attached bacteria are ∼1000 times more resistant to antibiotics than planktonic cells. The rapid spread of...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2013.07.120

    authors: Badawy HT,Pasetto P,Mouget JL,Pilard JF,Cutright TJ,Milsted A

    更新日期:2013-09-06 00:00:00

  • Enhanced cellular uptake of CpG DNA by α-helical antimicrobial peptide Kn2-7: Effects on macrophage responsiveness to CpG DNA.

    abstract::DNA containing unmethylated cytosine-guanine motifs (CpG DNA) initiates innate immune responses, including the secretion of cytokines from macrophages. Some antimicrobial peptides modulate the responses to CpG DNA, although the molecular mechanisms of this process remain unclear. This study examined the effects of fou...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2020.07.013

    authors: Nishihara S,Kawasaki K

    更新日期:2020-09-10 00:00:00

  • Degradation of dynorphin-(1-13) and dynorphin-(1-17) by the neuroblastoma cell membrane. Evidence for the involvement of a cysteine protease.

    abstract::The membrane of mouse neuroblastoma N-18 cells degraded dynorphin-(1-13), dynorphin-(1-17), and Leu-enkephalin. The degradation of the former two peptides was inhibited strongly by N-ethylmaleimide, moderately by diisopropylphosphorofluoridate and phosphoramidon, and slightly by bestatin. When Leu-enkephalin was the s...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(86)91095-8

    authors: Satoh M,Yokosawa H,Ishii S

    更新日期:1986-10-15 00:00:00

  • PICOT binding to the polycomb group protein, EED, alters H3K27 methylation at the MYT1 PRC2 target gene.

    abstract::PICOT is a ubiquitous protein that has no functional redundant ortholog and is critical for mouse embryonic development. It is involved in the regulation of signal transduction in T lymphocytes and cardiac muscle, and in cellular iron metabolism and biogenesis of Fe/S proteins. However, very little is known about the ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2018.12.153

    authors: Pandya P,Pasvolsky R,Babichev Y,Braiman A,Witte S,Altman A,Isakov N

    更新日期:2019-02-05 00:00:00

  • miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARgamma expression.

    abstract::microRNAs (miRNAs) are non-coding small RNAs regulating gene expression, cell growth, and differentiation. Although several miRNAs have been implicated in cell growth and differentiation, it is barely understood their roles in adipocyte differentiation. In the present study, we reveal that miR-27a is involved in adipo...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2010.01.012

    authors: Kim SY,Kim AY,Lee HW,Son YH,Lee GY,Lee JW,Lee YS,Kim JB

    更新日期:2010-02-12 00:00:00

  • Rescue of CH31 B cells from antigen receptor-induced apoptosis by inhibition of p38 MAPK.

    abstract::CH31 B lymphomas represent a model for antigen-induced deletional tolerance of immature B lymphocytes, because cross-linking the B cell antigen receptor (BCR) induces G(1) phase arrest and apoptosis. We have recently demonstrated that BCR cross-linking leads to a transient activation of p38 mitogen-activated protein k...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.2000.3489

    authors: Swart JM,Chiles TC

    更新日期:2000-09-24 00:00:00

  • Phosphorylation and nuclear processing of the androgen receptor.

    abstract::Although transformed androgen receptor (AR) complexes derived from cytosol and nuclear AR complexes have been shown to bind with high affinity to nuclei and DNA, we have shown that the binding characteristics of the two receptor populations to rat ventral prostate nuclei are different. To account for these differences...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(90)91398-c

    authors: Golsteyn EJ,Goren HJ,Lehoux JG,Lefebvre YA

    更新日期:1990-08-31 00:00:00

  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin increases reliance on fats as a fuel source independently of diet: evidence that diminished carbohydrate supply contributes to dioxin lethality.

    abstract::The environmental toxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes a wasting syndrome marked by hypophagia, loss of body fat, changes in intermediary metabolism and death. Use of conventional laboratory animals has not resolved whether or not TCDD affects intermediary metabolism independently of hypophagia. We...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(91)91558-t

    authors: Lentnek M,Griffith OW,Rifkind AB

    更新日期:1991-02-14 00:00:00

  • Molecular cloning and characterization of rat lin-10.

    abstract::In Caenorhabditis elegans, the vulval induction is mediated by tyrosine kinase receptor/Ras signal transduction pathway composed of the lin-3, let-23, and let-60 products. In addition to these gene products, the lin-2, lin-7, and lin-10 products are also implicated in this pathway. Lin-2 encodes a MAGUK and lin-7 enco...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1998.8142

    authors: Ide N,Hirao K,Hata Y,Takeuchi M,Irie M,Yao I,Deguchi M,Toyoda A,Nishioka H,Mizoguchi A,Takai Y

    更新日期:1998-02-13 00:00:00

  • Replacing C189 in the bZIP domain of Zta with S, T, V, or A changes DNA binding specificity to four types of double-stranded DNA.

    abstract::Zta is a bZIP transcription factor (TF) in the Epstein-Barr virus that binds unmethylated and methylated DNA sequences. Substitution of cysteine 189 of Zta to serine (Zta(C189S)) results in a virus that is unable to execute the lytic cycle, which was attributed to a change in binding to methylated DNA sequences. To le...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2018.05.080

    authors: Ray S,Tillo D,Assad N,Ufot A,Deppmann C,Durell SR,Porollo A,Vinson C

    更新日期:2018-07-02 00:00:00

  • Intersubunit crosslinking of the heterotetrameric proton-translocating pyridine nucleotide transhydrogenase of Escherichia coli defines intersubunit contacts between transmembrane helices of the beta subunits.

    abstract::The proton-translocating pyridine nucleotide transhydrogenase of Escherichia coli is composed of two types of subunits, alpha and beta, organized as an alpha(2)beta(2) tetramer. The protein contains three recognizable domains, of which domain II is the transmembrane region of the molecule containing the pathway for pr...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.2000.4142

    authors: Hou C,Bragg PD

    更新日期:2001-01-19 00:00:00

  • Tertiary structure prediction of SARS coronavirus helicase.

    abstract::SARS coronavirus, SCV, has been recently responsible of a sudden and widespread infection which caused almost 800 victims. The limited amount of SCV protein structural information is partially responsible of the lack of specific drugs against the virus. Coronavirus helicases are very conserved and peculiar proteins wh...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2006.03.069

    authors: Bernini A,Spiga O,Venditti V,Prischi F,Bracci L,Huang J,Tanner JA,Niccolai N

    更新日期:2006-05-19 00:00:00

  • Diagnosis of familial amyloidotic polyneuropathy by recombinant DNA techniques.

    abstract::An amino acid substitution of Met for Val at position 30 of plasma prealbumin is known to be closely related to heredo-familial amyloidotic polyneuropathy(FAP). As a first step in development of a direct method for diagnosis of the disease, cDNA for normal human prealbumin was cloned and its nucleotide sequence was de...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(84)90586-2

    authors: Sasaki H,Sakaki Y,Matsuo H,Goto I,Kuroiwa Y,Sahashi I,Takahashi A,Shinoda T,Isobe T,Takagi Y

    更新日期:1984-12-14 00:00:00