Abstract：
:HSV-2 induces the transcription of c-fos gene in both human (diploid) cell strains and mouse (heteroploid) cell lines. HSV-1 is incapable of such induction. The induction of transcription is rapid and transient in both cell types. The product of transcriptional induction of c-fos in mouse cells is mainly a 4.5 kb fos mRNA along with lesser amount of a 2.2 kb fos mRNA, while in human cells the 4.5 kb mRNA is the only detectable product. Both the 4.5 kb and 2.2 kb fos mRNAs are mature gene products as judged by their presence exclusively in the cytoplasm of infected mouse L929 cells, while a 3.5 kb putative precursor of the 2.2 kb fos mRNA appears exclusively in the nucleus. In infected human WI38 cells, the 4.5 kb mRNA also appears exclusively in the cytoplasm. Virus specific protein synthesis is an absolute requirement for the transcriptional activation. The 4.5 kb fos mRNA is under different control mechanisms since it is not induced by serum stimulation of serum starved cells as is the 2.2 kb fos transcript. Moreover, in serum starved cells simultaneously stimulated by serum and infected, only the 2.2 kb fos transcript can be superinduced by the protein synthesis inhibitor cycloheximide, while the appearance of the 4.5 kb fos mRNA is completely blocked by this treatment.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Goswami BBdoi
10.1016/0006-291x(87)90359-7subject
Has Abstractpub_date
1987-03-30 00:00:00pages
1055-62issue
3eissn
0006-291Xissn
1090-2104pii
0006-291X(87)90359-7journal_volume
143pub_type
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journal_title：Biochemical and biophysical research communications
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journal_title：Biochemical and biophysical research communications
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journal_title：Biochemical and biophysical research communications
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journal_title：Biochemical and biophysical research communications
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journal_title：Biochemical and biophysical research communications
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
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journal_title：Biochemical and biophysical research communications
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更新日期：2006-12-08 00:00:00
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journal_title：Biochemical and biophysical research communications
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
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更新日期：2009-07-10 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
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更新日期：2009-02-06 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1006/bbrc.1995.1355
更新日期：1995-03-08 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章,评审
doi：10.1006/bbrc.1997.6802
更新日期：1997-06-18 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1006/bbrc.2001.6030
更新日期：2001-12-07 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
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更新日期：2015-11-27 00:00:00
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journal_title：Biochemical and biophysical research communications
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更新日期：2010-05-14 00:00:00
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journal_title：Biochemical and biophysical research communications
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更新日期：2002-09-20 00:00:00
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journal_title：Biochemical and biophysical research communications
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更新日期：2007-05-18 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
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更新日期：2001-04-20 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1016/j.bbrc.2003.08.129
更新日期：2003-10-10 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1006/bbrc.2001.4881
更新日期：2001-05-25 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1006/bbrc.1995.2250
更新日期：1995-09-05 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1006/bbrc.1999.1994
更新日期：2000-01-19 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
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更新日期：2003-10-31 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1016/s0006-291x(87)80038-4
更新日期：1987-04-29 00:00:00
abstract：:Transgenic mouse which produces human alpha-fetoprotein (AFP) ubiquitously was used to study carbohydrate structures of AFP produced by various tissues as well as that in the serum. A series of tissues from the transgenic mouse were cultured in vitro and the AFP produced was analyzed by affinity electrophoreses with 4...
journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1006/bbrc.1996.0969
更新日期：1996-06-25 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1016/j.bbrc.2013.07.006
更新日期：2013-08-23 00:00:00
