Feedback-type inhibition of activity of 3-hydroxy-3-methylglutaryl coenzyme a reductase by ubiquinone.

abstract：:Pluripotent embryonic stem (ES) cells are the most versatile cells, with the potential to differentiate into all types of cell lineages including neural precursor cells (NPCs), which can be expanded in large numbers for significant periods of time to provide a reliable cell source for transplantation in neurodegenerat...

journal_title：Biochemical and biophysical research communications

authors： Xu H,Fan X,Wu X,Tang J,Yang H

更新日期：2005-01-07 00:00:00

abstract：:Bovine heart cytochrome c oxidase, depleted of polypeptide subunits by alkaline detergent treatment, was characterized with respect to metal content, optical spectral properties, and oxidase activity. Treatment with 1.0% Triton X-100 at pH 9.5 followed by anion-exchange chromatography caused removal of subunit III, su...

journal_title：Biochemical and biophysical research communications

authors： Yewey GL,Caughey WS

更新日期：1987-11-13 00:00:00

abstract：:High performance liquid chromatographic (HPLC) analysis showed that the prototype antioxidant ascorbate (vitamin C) inhibits the DNA adducts induced by synthetic estrogen diethylstilbestrol (DES) and the antiestrogen metabolite 4-hydroxytamoxifen (4-OHTam). Treatment of salmon testes DNA with 4-OHTam quinone or 4-OHTa...

journal_title：Biochemical and biophysical research communications

authors： Sharma M,Slocum HK

更新日期：1999-09-07 00:00:00

abstract：:Prion diseases are characterized by the accumulation of a pathological form of prion protein (PrP(Sc)), which behaves as an infectious agent. Here we developed an in vitro co-culture system to analyze the PrP(Sc) transmission from ScN2a cell, which persistently retains PrP(Sc), to naïve N2a cell. In this cell-to-cell ...

journal_title：Biochemical and biophysical research communications

authors： Tanaka M,Hara H,Nishina H,Hanada K,Hagiwara K,Maehama T

更新日期：2010-07-02 00:00:00

abstract：:We have previously reported that alpha-fetoprotein (AFP) inhibits infection of human monocyte-derived macrophages (MDM) by R5-HIV-1 strains and that a peptide mimicking the clade B HIV-1 gp120 consensus V3 domain (V3Cs) binds to CCR5. We demonstrate here that AFP binds high- and low-affinity binding sites of MDM, char...

journal_title：Biochemical and biophysical research communications

authors： Atemezem A,Mbemba E,Marfaing R,Vaysse J,Pontet M,Saffar L,Charnaux N,Gattegno L

更新日期：2002-08-23 00:00:00

abstract：BACKGROUND:Adiponectin (APN) is an adipocyte-derived bioactive molecule with anti-diabetic and anti-atherogenic properties. Although anti-diabetic effects are mostly mediated by the adiponectin receptors AdipoR1 and AdipoR2, the anti-atherogenic mechanisms have not been fully elucidated. METHODS AND RESULTS:In this st...

journal_title：Biochemical and biophysical research communications

authors： Yamamoto H,Kuroda N,Uekita H,Kochi I,Matsumoto A,Niinaga R,Funahashi T,Shimomura I,Kihara S

更新日期：2016-02-05 00:00:00

abstract：:The metabolism of d-glucose and its pentaacetate ester was investigated in GLUT4 null mice and control C57Bl6/CBA mice. The incorporation of d-[U-(14)C]glucose (1.7 mM) into glycogen of diaphragm, soleus, and extensor digitorium longus muscles averaged, in the GLUT4 null mice, only 34 +/- 7% of the mean corresponding ...

journal_title：Biochemical and biophysical research communications

authors： Ladrière L,Charron MJ,Malaisse WJ

更新日期：1999-11-02 00:00:00

abstract：:Telmisartan, an angiotensin II type 1 receptor blocker (ARB), attenuates hyperglycemia-aggravated vascular inflammation by decreasing IκB kinase β (IKKβ) expression in endothelial cells. Because glycogen synthase 3β (GSK3β) is involved in inflammatory process by regulating nuclear factor-κB (NF-κB) activity, we invest...

journal_title：Biochemical and biophysical research communications

authors： Song KH,Bae SJ,Chang J,Park JH,Jo I,Cho KW,Cho DH

更新日期：2017-09-30 00:00:00

abstract：:A fragment of human gene for pregnancy-specific beta 1-glycoprotein(s), recently identified CEA family member(s), has been cloned. Analyses of nucleotide and deduced amino acid sequences revealed that it carried, from 5' to 3' direction, exons IA, IB, IIA, IIB, C3, C1 and C2, the first four encoding peptides distinct ...

journal_title：Biochemical and biophysical research communications

authors： Oikawa S,Inuzuka C,Kosaki G,Nakazato H

更新日期：1988-10-14 00:00:00

abstract：:We have deduced the exon structure of the 5' untranslated region of the human cardiac alpha-myosin heavy chain gene by cloning a cDNA for this region using the polymerase chain reaction. Comparison of the cDNA and genomic DNA sequences demonstrates that the 5' non-coding region of the alpha-myosin heavy chain gene is ...

journal_title：Biochemical and biophysical research communications

authors： Brand NJ,Dabhade N,Yacoub M,Barton PJ

更新日期：1991-09-30 00:00:00

abstract：:The muscarinic acetylcholine receptor was solubilized, in a sensitive form for GTP and Na+, from bovine cerebral cortex using a zwitterionic detergent 3-[(3-cholamidopropyl)-dimethylammonio]-1-propane sulfonate. The solubilized muscarinic receptor displayed characteristics as follows: (1) high affinity to nanomolar co...

journal_title：Biochemical and biophysical research communications

authors： Kuno T,Shirakawa O,Tanaka C

更新日期：1983-05-16 00:00:00

abstract：:The aim of this work was to study the time course of the oxidative metabolism in mice lung after exposure to ambient particles (ROFA). Swiss mice were intranasally instilled with a ROFA suspension (0.20 mg/kg). Animals were sacrificed 1 or 3 h after the exposure. Eighty percentage of increased oxygen consumption was o...

journal_title：Biochemical and biophysical research communications

authors： Magnani ND,Marchini T,Tasat DR,Alvarez S,Evelson PA

更新日期：2011-09-09 00:00:00

abstract：:In chaperoning dithiothreitol-denatured alpha-lactabumin, alpha-crystallin forms a chaperoning complex. In order to study the kinetics of such chaperoning it needs to be established whether the formation of the chaperoning complex is a reversible or irreversible process. The chaperoning reaction was studied by dynamic...

journal_title：Biochemical and biophysical research communications

authors： Neal R,Zigler JS Jr,Bettelheim FA

更新日期：2001-01-12 00:00:00

abstract：:Structural determinants of L-[(3)H]nicotine binding to synthetic peptides comprising residues 188-207 of nicotinic acetylcholine receptor alpha subunits were invesitigated by equilibrium binding analysis. Two binding components were detected, one of low affinity (K(d) approximately 1.5 microM) that did not differ sign...

journal_title：Biochemical and biophysical research communications

authors： Lentz TL

更新日期：2000-02-16 00:00:00

abstract：:Primary effusion lymphoma (PEL) is an aggressive neoplasm caused by Kaposi's sarcoma-associated herpesvirus (KSHV). This study provides evidence that proteasomal activity is required for both survival of PEL cells stably harboring the KSHV genome and viral replication of KSHV. We evaluated the cytotoxic effects of pro...

journal_title：Biochemical and biophysical research communications

authors： Saji C,Higashi C,Niinaka Y,Yamada K,Noguchi K,Fujimuro M

更新日期：2011-12-02 00:00:00

abstract：:In a 28-year-old man with myopathy and phosphorylase kinase (PhK) deficiency, we found a G-to-C substitution at the 5' end of an intron in the muscle-specific alpha-subunit gene. The mutation destroys the high-consensus GT sequences at the 5' splice junction of the intron, which causes skipping of the preceding exon. ...

journal_title：Biochemical and biophysical research communications

authors： Bruno C,Manfredi G,Andreu AL,Shanske S,Krishna S,Ilse WK,DiMauro S

更新日期：1998-08-28 00:00:00

abstract：:The sequence for the 3' portion of amoB, a gene encoding a 43-kDa polypeptide component ammonia monooxygenase of Nitrosomonas europaea, is presented. The derived polypeptide has no homology with other known proteins. AmoA and amoB are the only open reading frames in the putative amo operon. ...

journal_title：Biochemical and biophysical research communications

authors： Bergmann DJ,Hooper AB

更新日期：1994-10-28 00:00:00

abstract：:Receptor activator of NF-κB (RANK) and RANK ligand (RANKL) are known to play an important role in the development and progression of breast cancer. However, the mechanisms by which stimuli regulate the expression of RANK and RANKL in breast cancer cells are largely unknown. In this study, we show that hypoxia, a commo...

journal_title：Biochemical and biophysical research communications

authors： Tang ZN,Zhang F,Tang P,Qi XW,Jiang J

更新日期：2011-05-13 00:00:00

abstract：:In pulse-chase experiments ([35S]Met as radioactive label) 4 intracellular forms of the alpha-subunit (apparent molecular weights of 11, 16.5, 19.5, and 23.4 kDa) were observed whereas almost no label was incorporated into the beta-subunit. The 23.4 kDa form was secreted as free alpha-subunit, the others were precurso...

journal_title：Biochemical and biophysical research communications

authors： Hilf G,Merz WE

更新日期：1989-02-28 00:00:00

abstract：:Many organisms do not contain the necessary biochemical armoury to carry out the initial oxidative attack of many pollutant chemicals. In the present study, Acinetobacter sp. strain BD413 has been genetically engineered to express the cytochrome P450 xenobiotic-metabolising enzyme CYP105D1 from Streptomyces griseus th...

journal_title：Biochemical and biophysical research communications

authors： Lamb DC,Kelly DE,Masaphy S,Jones GL,Kelly SL

更新日期：2000-09-24 00:00:00

abstract：:It is unknown how very short introns (<65 nt; termed 'ultra-short' introns) could be spliced in a massive spliceosome (>2.7 MDa) without steric hindrance. By screening an annotated human transcriptome database (H-InvDB), we identified three model ultra-short introns: the 56-nt intron in the HNRNPH1 (hnRNP H1) gene, th...

journal_title：Biochemical and biophysical research communications

authors： Sasaki-Haraguchi N,Shimada MK,Taniguchi I,Ohno M,Mayeda A

更新日期：2012-06-29 00:00:00

abstract：:Terminal Schwann cells (TSCs) that cover motor neuron terminals are known to play important roles in maintaining neuromuscular junctions, as well as in the repair process after nerve injury. However, molecular characteristics of TSCs remain unknown, because of the difficulties in analyzing them due to their paucity. W...

journal_title：Biochemical and biophysical research communications

authors： Oda R,Yaoi T,Okajima S,Kobashi H,Kubo T,Fushiki S

更新日期：2003-09-05 00:00:00

abstract：:Osteoporosis is a common bone disorder with adverse effects on oral osseointegration, and the effects of metformin on bone metabolism have received increasing attention. The aim of the present study was to test the hypothesis that metformin promoted osteogenesis of bone mesenchymal stem cells (BMSCs) and osseointegrat...

journal_title：Biochemical and biophysical research communications

authors： Lin J,Xu R,Shen X,Jiang H,Du S

更新日期：2020-10-15 00:00:00

abstract：:Simultaneous incubation of bovine adrenal medullary plasma membranes (PM) with chromaffin granules (CG) resulted in the release of the soluble granular content. The molecular mechanism of this process was studied with several monoclonal antibodies (mAb) raised against different plasma membrane components. Specific inh...

journal_title：Biochemical and biophysical research communications

authors： Bohner K,Boons J,Gheuens J,Konings F,De Potter WP

更新日期：1985-12-31 00:00:00

abstract：:A fractionation of the membrane extract of rat testes revealed the existence of pp60c-src kinase activity. The expression of pp60c-src was examined in the developing rat testes. The immunecomplex kinase assay using a monoclonal antibody specific to pp60c-src (mAb327) showed that the expression of pp60c-src kinase acti...

journal_title：Biochemical and biophysical research communications

authors： Nishio H,Tokuda M,Itano T,Matsui H,Takeuchi Y,Hatase O

更新日期：1995-01-17 00:00:00

abstract：:In mammalian cells, the Rab7 protein is a key element of late endocytic membrane traffic. Several results suggest that it is involved in the transport from early to late endosome or from late endosome to lysosome. We have previously characterized a Rab7 gene homologue (TcRAB7) in Trypanosoma cruzi. Now, using an affin...

journal_title：Biochemical and biophysical research communications

authors： Araripe JR,Cunha e Silva NL,Leal ST,de Souza W,Rondinelli E

更新日期：2004-08-20 00:00:00

abstract：:Using isolated liver mitochondria we show that low concentrations of TBT (0.5 microM) cause the release of mitochondrial cytochrome c, in the presence of Ca(2+). This is reflected in a rapid loss of membrane potential (DeltaPsi(m)), and a large-amplitude swelling characteristic of mitochondrial permeability transition...

journal_title：Biochemical and biophysical research communications

authors： Gogvadze V,Stridh H,Orrenius S,Cotgreave I

更新日期：2002-04-12 00:00:00

abstract：:The nucleotide sequence of the 5S rRNA from a mushroom, Coprinus cinereus, was determined to be: (sequence in text). This sequence is consistent with current models for the secondary structure of 5S RNAs and indicates a very high degree of sequence conservation among the most highly evolved fungi. Sequence heterogenei...

journal_title：Biochemical and biophysical research communications

authors： Liu WY,Nazar RN

更新日期：1983-10-14 00:00:00

abstract：:Endochondral bone formation is an important process in development and growth of the skeleton; still many of the mechanisms of growth cartilage remain unknown. The aim of this study was to identify genes specifically expressed in growth cartilage by constructing a subtraction cDNA library of the articular-epiphyseal c...

journal_title：Biochemical and biophysical research communications

authors： Johannessen MK,Skretting G,Ytrehus B,Røed KH

更新日期：2007-03-23 00:00:00

abstract：UNLABELLED:The L-arginine-nitric oxide (NO) pathway was investigated in human internal mammary artery (HIMA) in vitro. HIMA rings were mounted in organ bath, and then incubated in Krebs buffer for 1 to 8 hrs, relaxing agents were tested. Under these conditions, L-arginine (0.1 microM - 1 mM) elicited only minor relaxat...

journal_title：Biochemical and biophysical research communications

authors： Qi X,Chen D,Nottin R,Mace L,Herve P,Weiss M

更新日期：1993-08-31 00:00:00