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Evidence of L-arginine/nitric oxide pathway in endothelium and smooth muscle of human internal mammary artery.

Abstract：

UNLABELLED:The L-arginine-nitric oxide (NO) pathway was investigated in human internal mammary artery (HIMA) in vitro. HIMA rings were mounted in organ bath, and then incubated in Krebs buffer for 1 to 8 hrs, relaxing agents were tested. Under these conditions, L-arginine (0.1 microM - 1 mM) elicited only minor relaxation after 2 hr incubation, whereas with increased incubation time (4, 6, 8 hrs), the concentration-dependent relaxation to L-arginine increased significantly in endothelium-intact and -denuded vessels. NG-nitro-L-arginine (100 microM) or NG-monomethyl-L-arginine (100 microM) or methylene blue (2.7 microM) partially inhibited L-arginine relaxation. In endothelium-intact HIMA and in both types of rings A23187 (10 microM) and L-arginine (100 microM), respectively, increased the concentration of NO in medium and cGMP content of vascular tissues. These increases were partially inhibited by NG-nitro-L-arginine (100 microM) or methylene blue (2.7 microM). CONCLUSION:in smooth muscle of HIMA L-arginine-NO conversion is calcium independent, which is different from that in endothelium.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Qi X,Chen D,Nottin R,Mace L,Herve P,Weiss M

doi

10.1006/bbrc.1993.2014

subject

Has Abstract

pub_date

1993-08-31 00:00:00

pages

90-6

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(83)72014-0

journal_volume

195

pub_type

杂志文章

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