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Short-term desensitization of phosphatidylinositol turnover via muscarinic acetylcholine receptors and histamine H1-receptors in smooth muscle.

Abstract：

:Smooth muscle of guinea-pig taenia caecum was desensitized by treatment with 10(-4)M carbachol or 10(-4)M histamine for 30 min in Ca-free solution containing 2mM EGTA. Phosphatidylinositol turnover stimulated by carbachol was not reduced by desensitization with either carbachol or histamine, while the turnover stimulated by histamine was reduced by desensitization with histamine, but not with carbachol. These results are consistent with our previous report (1) that heterologous desensitization induced by carbachol occurs at intracellular Ca stores and homologous desensitization by histamine occurs at H1 receptors.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hishinuma S,Uchida MK

doi

10.1016/0006-291x(89)92371-1

subject

Has Abstract

pub_date

1989-07-31 00:00:00

pages

733-9

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)92371-1

journal_volume

162

pub_type

杂志文章

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