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Identification and cloning of two novel allergens from the lipophilic yeast, Malassezia furfur.

Abstract：

:Two novel allergens, designated Mal f 2 and Mal f 3 according to the WHO/IUIS Allergen Nomenclature Subcommittee recommendation, were isolated from the lipophilic yeast Malassezia furfur cell extracts and the genes coding for those were cloned. Mal f 2 and Mal f 3 had apparent molecular weights of 21 kDa and 20 kDa, respectively, on SDS-PAGE under reducing conditions. The identified cDNA clone of Mal f 2 encoded an open reading frame of 177 amino acid residues. Fifty-one percent identity was found between the Mal f 2 and Mal f 3 sequences. Comparison of the Mal f 2 and Mal f 3 sequences with known protein sequences revealed that they had sequence homology with two peroxisomal membrane proteins of Candida boidinii and an Aspergillus fumigatus allergen, Asp f 3. In RAST, both Mal f 2- and Mal f 3-specific IgE antibodies could be detected in approximately 70 % of sera from M. furfur sensitized patients with atopic dermatitis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yasueda H,Hashida-Okado T,Saito A,Uchida K,Kuroda M,Onishi Y,Takahashi K,Yamaguchi H,Takesako K,Akiyama K

doi

10.1006/bbrc.1998.8944

subject

Has Abstract

pub_date

1998-07-20 00:00:00

pages

240-4

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(98)98944-6

journal_volume

248

pub_type

杂志文章

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