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MiRNA-92a protects pancreatic B-cell function by targeting KLF2 in diabetes mellitus.

Abstract：

AIMS:diabetes mellitus is one of the most common metabolic diseases worldwide characterized by insulin resistance and pancreatic β cell dysfunction. miRNA plays an important role in DM. In previous studies, miRNA-92a could function as targets for innovative precision medicines to reduce T1D islet autoimmunity. However, the relationship between miRNA-92a and pancreatic β cell dysfunction remains unknown. The aim of the study was to investigate the role of miRNA-92a in pancreatic β cell dysfunction. METHODS:Apoptosis, proliferation, insulin secretion and cell survival rate were detected to evaluate the function of miRNA-92a. RESULTS:we found that miRNA-92a could inhibit apoptosis induced by high-glucose environment and increase the insulin secretion and proliferation. Moreover, we identify the KLF2 as direct target of miRNA-92a, suggesting that miRNA-92a may function through regulating KLF2. CONCLUSION:Altogether, we verified the function and mechanism of miRNA-92a and provide evidence that miRNA-92a may serve a potential candidate for the clinical treatment for DM.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wang W,Wang J,Yan M,Jiang J,Bian A

doi

10.1016/j.bbrc.2018.04.097

subject

Has Abstract

pub_date

2018-06-07 00:00:00

pages

577-582

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(18)30876-3

journal_volume

500

pub_type

杂志文章

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