当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Interstitial chromatin alteration causes persistent p53 activation involved in the radiation-induced senescence-like growth arrest.

Interstitial chromatin alteration causes persistent p53 activation involved in the radiation-induced senescence-like growth arrest.

Abstract：

:Various stresses including ionizing radiation give normal human fibroblasts a phenotype of senescence-like growth arrest (SLGA), manifested by p53-dependent irreversible G1 arrest. To determine the mechanism of persistent activation of p53, we examined phosphorylated Ataxia telangiectasia mutated (ATM) and phosphorylated histone H2AX foci formation after X-irradiation. Although the multiple tiny foci, detected soon after (<30 min) irradiation, gradually disappeared, some of these foci changed to large foci and persisted for 5 days. Large foci containing phosphorylated ATM and gamma-H2AX co-localized and foci with p53 phosphorylated at serine 15 also showed the same distribution. Interestingly, the signals obtained by telomere fluorescence in situ hybridization (FISH) assay did not co-localize with 90% of the large foci. Our results indicate that chromatin alteration in interstitial chromosomal regions is the most likely cause of continuous activation of p53, which results in the induction of SLGA by ionizing radiation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Suzuki M,Suzuki K,Kodama S,Watanabe M

doi

10.1016/j.bbrc.2005.11.167

subject

Has Abstract

pub_date

2006-02-03 00:00:00

pages

145-50

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)02693-8

journal_volume

340

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Interleukin-1 beta analogues with markedly reduced pyrogenic activity can stimulate secretion of adrenocorticotropic hormone in rats.

    abstract：:We examined the adrenocorticotropic hormone-releasing activities of several human interleukin-1 beta analogues that have markedly reduced pyrogenic activities in rats. Among the analogues tested, [Gly4]-, [Leu93]- and [1-148]-interleukin-1 beta increased the plasma adrenocorticotropic hormone level to almost that indu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)91736-c

    authors： Naito Y,Fukata J,Masui Y,Hirai Y,Murakami N,Tominaga T,Nakai Y,Tamai S,Mori K,Imura H

    更新日期：1990-02-28 00:00:00

  • The solution structure of heregulin-alpha and a N-terminal mutant with suppressed activity.

    abstract：:NMR spectroscopy is used to compare the structure of the EGF-like domain of heregulin-alpha and HT1, a mutated form of heregulin-alpha with significantly reduced activity. HT1 is a chimeric protein that has the first seven residues of transforming growth factor-alpha and the sequence of heregulin-alpha from the first ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.9437

    authors： Adler M,Thompson SA

    更新日期：1999-03-05 00:00:00

  • Transverse motion of spin-labeled 3,3',5-triiodo-L-thyronine in phospholipid bilayers.

    abstract：:Using electron spin resonance stop-flow technique, the transverse motion (flip-flop) of 3-([alpha-carboxy-4-(4-hydroxy-3-iodophenoxy)-3,5- diiodophenethyl]carbamoyl)-2,2,5,5-tetramethyl-3-pyrrolin (T3-SL) in dipalmitoyl L-alpha-phosphosphatidylcholine (DPPC) membranes was evaluated. At 22 degrees C, the electron spin ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91817-0

    authors： Lai CS,Korytowski W,Niu CH,Cheng SY

    更新日期：1985-08-30 00:00:00

  • Isolation and primary structure of a neuropeptide hormone from Heliothis zea with hypertrehalosemic and adipokinetic activities.

    abstract：:A neuropeptide was isolated from the corpora cardiaca of the corn earworm moth Heliothis zea, and purified by sequential gradient elution in three reversed phase-high performance liquid chromatographic steps. The primary structure, pGlu-Leu-Thr-Phe-Ser-Ser-Gly-Trp-Gly-Asn-NH2 was determined by automated gas-phase Edma...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)81091-x

    authors： Jaffe H,Raina AK,Riley CT,Fraser BA,Bird TG,Tseng CM,Zhang YS,Hayes DK

    更新日期：1988-08-30 00:00:00

  • Phospholipase C δ1 negatively regulates autophagy in colorectal cancer cells.

    abstract：:Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Kirsten rat sarcoma viral oncogene homolog (KRAS) is frequently mutated in CRC, and KRAS mutations promote cell motility, growth, and survival. We previously revealed that the expression of phospholipase C (PLC) δ1, one of the most...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.05.098

    authors： Shimozawa M,Anzai S,Satow R,Fukami K

    更新日期：2017-07-08 00:00:00

  • BST2 inhibits infection of influenza A virus by promoting apoptosis of infected cells.

    abstract：:BST2 is an antiviral factor that inhibits the release of enveloped virus at the plasma membrane via an unusual topology in which its N-terminal is in the cytosol while its C-terminal is anchored by glycophosphatidylinositol (GPI). BST2-deficient cells showed substantially higher release of virions than wild type cells...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.12.110

    authors： Yi E,Oh J,Kang HR,Song MJ,Park SH

    更新日期：2019-02-05 00:00:00

  • Epicatechin selectively prevents nitration but not oxidation reactions of peroxynitrite.

    abstract：:The flavanol (-)-epicatechin has been found to protect against damage inflicted by peroxynitrite, an inflammatory intermediate. Here, epicatechin was tested in systems of increasing complexity. The compound efficiently protected against nitration of protein tyrosine residues by peroxynitrite (IC(50) approximately 0.02...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5210

    authors： Schroeder P,Klotz LO,Buchczyk DP,Sadik CD,Schewe T,Sies H

    更新日期：2001-07-20 00:00:00

  • Alternative pathway linked by hydrogen bonds connects heme-Fe of cytochrome c with subunit II-CuA of cytochrome a.

    abstract：:The bridging element for electron transfer in proteins is the hydrogen bond according to the new experimental perspective in preference to carbon-carbon σ-bond presently used. The purpose of this study is to identify an alternative pathway linked by hydrogen bonds suitable for electron transfer from heme-Fe of cytochr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.09.141

    authors： Ramasarma T,Vaigundan D

    更新日期：2018-10-28 00:00:00

  • Reduction of PTP1B by RNAi upregulates the activity of insulin controlled fatty acid synthase promoter.

    abstract：:Metabolic deregulation accompanying type II diabetes is characterized by insulin resistance in peripheral tissues (liver, muscle, and adipose), mediated by impairments in insulin receptor (IR) signaling. Protein tyrosine phosphatase 1B (PTP1B) has been shown to be a negative regulator of IR autophosphorylation and thu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.02.016

    authors： Xu J,Li L,Qian Z,Hong J,Shen S,Huang W

    更新日期：2005-04-08 00:00:00

  • Induction and regulation of CD8+ cytolytic T cells in human tuberculosis and HIV infection.

    abstract：:Tuberculosis and HIV continue to be the world-leading killers among infectious diseases, primarily affecting poor people in many developing countries. Despite differences in the immunopathogenesis of human infection with tuberculosis and HIV, experimental evidence from clinical studies and relevant animal models can b...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2010.02.141

    authors： Brighenti S,Andersson J

    更新日期：2010-05-21 00:00:00

  • G-protein dissociation, GTP-GDP exchange and GTPase activity in control and PMA treated neutrophils stimulated by fMet-Leu-Phe.

    abstract：:The addition of the chemotactic factor fMet-Leu-Phe to cell homogenates causes a decrease in the pertussis toxin catalyzed ADP-ribosylation of a 41 kDa protein. The fMet-Leu-Phe induced decrease is not abolished in homogenates prepared from phorbol 12-myristate 13-acetate treated neutrophils. This decreased ribosylati...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91380-5

    authors： Matsumoto T,Molski TF,Kanaho Y,Becker EL,Sha'afi RI

    更新日期：1987-03-13 00:00:00

  • Suppression of the neoplastic phenotype by replacement of the Tsc2 gene in Eker rat renal carcinoma cells.

    abstract：:The hereditary renal carcinoma (RC) in the rat, originally reported by R. Eker in 1954, is an excellent example of a Mendelian dominantly inherited predisposition to a specific cancer in an experimental animal. Recently, we have identified a germline mutation of the sclerosis (Tsc2) gene in the Eker rat (Nature Geneti...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.0183

    authors： Orimoto K,Tsuchiya H,Kobayashi T,Matsuda T,Hino O

    更新日期：1996-02-06 00:00:00

  • Expression of the C-terminal domain of novel human SR-A1 protein: interaction with the CTD domain of RNA polymerase II.

    abstract：:We have recently cloned a new member of the human Ser/Arg-rich superfamily (SR) of pre-mRNA splicing factors, SR-A1. Members of the SR family of proteins have been shown to interact with the C-terminal domain (CTD) of the large subunit of RNA polymerase II, and participate in pre-mRNA splicing. The largest subunit of ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.06.053

    authors： Katsarou ME,Papakyriakou A,Katsaros N,Scorilas A

    更新日期：2005-08-19 00:00:00

  • Molecular characterization of genetic mutation in human lactate dehydrogenase-A (M) deficiency.

    abstract：:Human lactate dehydrogenase-A mutant gene was isolated from the genomic DNA library of a patient deficient in LDH-A (Muscle) subunit. The nucleotide sequences of seven protein-coding exons were determined and a deletion of 20 base-pairs in exon 6 was found. This mutation results in a frame-shift translation and premat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)92374-9

    authors： Maekawa M,Sudo K,Kanno T,Li SS

    更新日期：1990-04-30 00:00:00

  • AIMP1 regulates TCR signaling and induces differentiation of regulatory T cells by interfering with lipid raft association.

    abstract：:In addition to a role in translation, AIMP1 is secreted to affect various immune cells, such as macrophages, dendritic cells, B cells, and natural killer cells. However, the direct effects of AIMP1 on T cells have not yet been reported. In this study, we investigated whether AIMP1 could modulate T cell responses direc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.05.040

    authors： Kim MS,Lee A,Cho D,Kim TS

    更新日期：2019-06-30 00:00:00

  • Cloning, expression, and mapping of a mouse gene, Uchl4, highly homologous to human and mouse Uchl3.

    abstract：:Ubiquitin carboxyl-terminal hydrolases (UCHs) are implicated in the proteolytic processing of polymeric ubiquitin. We have isolated a novel mouse gene for ubiquitin carboxyl-terminal hydrolase isozyme L4. The gene named Uchl4 encodes a novel member of the family of ubiquitin carboxyl-terminal hydrolases (UCHs) whose p...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4841

    authors： Osawa Y,Wang YL,Osaka H,Aoki S,Wada K

    更新日期：2001-05-11 00:00:00

  • Ras proteins regulate multiple mitogenic pathways in A10 vascular smooth muscle cells.

    abstract：:We examined the role of ras proteins in mitogenesis and proliferation of A10 smooth muscle cells. An assay was developed in which a dominant negative ras gene could be transiently expressed in vascular smooth muscle cells. As opposed to cells transfected with a control plasmid, those transfected with a dominant negati...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2065

    authors： Irani K,Herzlinger S,Finkel T

    更新日期：1994-08-15 00:00:00

  • Chemical repair of base lesions, AP-sites, and strand breaks on plasmid DNA in dilute aqueous solution by ascorbic acid.

    abstract：:We quantified the damage yields produced in plasmid DNA by γ-irradiation in the presence of low concentrations (10-100 μM) of ascorbic acid, which is a major antioxidant in living systems, to clarify whether it chemically repairs radiation damage in DNA. The yield of DNA single strand breaks induced by irradiation was...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.03.075

    authors： Hata K,Urushibara A,Yamashita S,Shikazono N,Yokoya A,Katsumura Y

    更新日期：2013-05-03 00:00:00

  • Activation of metabotropic glutamate receptor 5 reduces the secondary brain injury after traumatic brain injury in rats.

    abstract：:A wealth of evidence has shown that microglia-associated neuro-inflammation is involved in the secondary brain injury contributed to the poor outcome after traumatic brain injury (TBI). In vitro studies were reported that activation of metabotropic glutamate receptor 5 (mGluR5) could inhibit the microglia-associated i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.12.046

    authors： Wang JW,Wang HD,Cong ZX,Zhang XS,Zhou XM,Zhang DD

    更新日期：2013-01-18 00:00:00

  • Calcium release associated with discharge of specific granule contents from human neutrophils.

    abstract：:Neutrophil discharge of calcium into the ambient medium was measured, using an ion-sensitive electrode, after cells were stimulated with phorbol myristate acetate. Dose-dependent calcium efflux was observed over the same range of stimulus concentrations associated with specific granule marker release. Calcium efflux w...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(88)90282-3

    authors： Styrt B,Schwartz MA,Klempner MS

    更新日期：1988-08-15 00:00:00

  • Epicatechin isolated from Tripterygium wilfordii extract reduces tau-GFP-induced neurotoxicity in zebrafish embryo through the activation of Nrf2.

    abstract：:Tau plays important roles in the assembly and stabilization of the microtubule structure to facilitate axonal transport in mammalian brain. The intracellular tau aggregates to form paired helical filaments leading to neurodegenerative disorders, collectively called tauopathies. In our previous report, we established a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.06.058

    authors： Wu BK,Yuan RY,Chang YP,Lien HW,Chen TS,Chien HC,Tong TS,Tsai HP,Fang CL,Liao YF,Chang CC,Chen RP,Huang CJ

    更新日期：2016-08-19 00:00:00

  • The small-molecule IAP antagonist AT406 inhibits pancreatic cancer cells in vitro and in vivo.

    abstract：:In the present study, we tested the anti-pancreatic cancer activity by AT406, a small-molecule antagonist of IAP (inhibitor of apoptosis proteins). In established (Panc-1 and Mia-PaCa-2 lines) and primary human pancreatic cancer cells, treatment of AT406 significantly inhibited cell survival and proliferation. Yet, sa...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.07.011

    authors： Jiang Y,Meng Q,Chen B,Shen H,Yan B,Sun B

    更新日期：2016-09-09 00:00:00

  • Hereditary tyrosinemia type 1 metabolites impair DNA excision repair pathways.

    abstract：:Hereditary tyrosinemia type 1 is an autosomal recessive metabolic disorder, which is caused by a defective fumarylacetoacetate hydrolase enzyme, and consequently metabolites such as succinylacetone and p-hydroxyphenylpyruvate accumulate. We used a modified comet assay to determine the effect of these metabolites on ba...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.09.002

    authors： van Dyk E,Steenkamp A,Koekemoer G,Pretorius PJ

    更新日期：2010-10-08 00:00:00

  • Transfection of "naked" siRNA results in endosomal uptake and metabolic impairment in cultured neurons.

    abstract：:RNA interference is rapidly becoming a powerful tool for gene silencing in mammalian cells. Introduction of siRNA into primary cells, however, remains one of the major difficulties of this novel technique. Using cationic lipid-based transfection reagents satisfactory transfection results are observed in cell lines, bu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.01.170

    authors： Lingor P,Michel U,Schöll U,Bähr M,Kügler S

    更新日期：2004-03-19 00:00:00

  • Dual assay for MCLV3 activity reveals structure-activity relationship of CLE peptides.

    abstract：:The dodecapeptide MCLV3 is a functional peptide, derived from the CLV3 precursor protein, which is a candidate ligand of the CLV1/CLV2 receptor complex that restricts the stem cell population in the shoot apical meristem (SAM). MCLV3 can induce shoot and root meristem consumption, the typical phenotype of transgenic p...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.09.139

    authors： Kondo T,Nakamura T,Yokomine K,Sakagami Y

    更新日期：2008-12-05 00:00:00

  • Inflammatory mechanism of Chlamydia trachomatis-infected HeLa229 cells regulated by Atg5.

    abstract：:The relation between autophagy and Chlamydia trachomatis infection remain inconclusive. In order to further understand the role of autophagy in C. trachomatis-infected cells. Atg5 silenced HeLa229 cell line was used to establish an autophagy inhibition C. trachomatis infection model. The results suggested that Atg5 se...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.09.132

    authors： Wang F,Zhang L,Lu X,Zhu Q,Shi T,Lu R,Yu P,Zhang H,Wang Y

    更新日期：2019-11-26 00:00:00

  • Thiamine disulfide as a potent inhibitor of human immunodeficiency virus (type-1) production.

    abstract：:Thiol and disulfide compounds were tested as an anti-HIV drug against transactivator (Tat)-mediated transactivation of HIV-1. Of all the compounds tested, thiamine disulfide, alpha-lipoic acid, and N-acetycysteine significantly depressed HIV-1 Tat activity. Thiamine disulfide alone in these compounds possessing anti-H...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2760

    authors： Shoji S,Furuishi K,Misumi S,Miyazaki T,Kino M,Yamataka K

    更新日期：1994-11-30 00:00:00

  • Mono(ADP-ribosyl)ation of the N2 amino groups of guanine residues in DNA by pierisin-2, from the cabbage butterfly, Pieris brassicae.

    abstract：:Pierisin-2 is a cytotoxic and apoptosis-inducing protein present in Pieris brassicae with a 91% homology in the deduced amino acid sequences to pierisin-1 from Pieris rapae. We earlier showed pierisin-1 to catalyze mono(ADP-ribosyl)ation of 2'-deoxyguanosine (dG) in DNA to form N2-(ADP-ribos-1-yl)-2'-deoxyguanosine, t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.08.132

    authors： Takamura-Enya T,Watanabe M,Koyama K,Sugimura T,Wakabayashi K

    更新日期：2004-10-15 00:00:00

  • Clonal cell populations unresponsive to radiosensitization induced by telomerase inhibition.

    abstract：:A combination of a radiotherapeutic regimen with telomerase inhibition is valuable when tumor cells are to be sensitized to radiation. Here, we describe cell clones unresponsive to radiosensitization after telomere shortening. After extensive division of individual transformed clones of mTERC-/- cells, about 22% of cl...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.09.091

    authors： Ju YJ,Shin HJ,Park JE,Juhn KM,Woo SR,Kim HY,Han YH,Hwang SG,Hong SH,Kang CM,Yoo YD,Park WB,Cho MH,Park GH,Lee KH

    更新日期：2010-11-12 00:00:00

  • Cloning and sequence of cDNA encoding a peptide C-terminal alpha-amidating enzyme from Xenopus laevis.

    abstract：:The C-terminal alpha-amide formation of the peptides is one of the most important events of prohormone processing. We have recently isolated an alpha-amidating enzyme, AE-I, from Xenopus laevis skin, which is the only enzyme ever purified to homogeneity. In this study, we report cloning and sequence of cDNA encoding A...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)90911-9

    authors： Mizuno K,Ohsuye K,Wada Y,Fuchimura K,Tanaka S,Matsuo H

    更新日期：1987-10-29 00:00:00