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Cloning, expression, and mapping of a mouse gene, Uchl4, highly homologous to human and mouse Uchl3.

Abstract：

:Ubiquitin carboxyl-terminal hydrolases (UCHs) are implicated in the proteolytic processing of polymeric ubiquitin. We have isolated a novel mouse gene for ubiquitin carboxyl-terminal hydrolase isozyme L4. The gene named Uchl4 encodes a novel member of the family of ubiquitin carboxyl-terminal hydrolases (UCHs) whose predicted amino acid sequence shows 95% identity to mouse UCH-L3 and 94% identity to human UCH-L3. Genomic structure, chromosome localization, and expression pattern of Uchl3 and Uchl4 were characterized in the mouse. Both Uchl3 and Uchl4 were expressed in various tissues examined; however, expression level was quite lower in Uchl4. While Uchl3 consists of at least 9 exons spanning about 12 kb, Uchl4 was an intronless gene with a size of about 2 kb. By PCR-based analysis with T31 radiation hybrid mapping panel, Uchl3 and Uchl4 were mapped on mouse chromosome 9 and 14, respectively.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Osawa Y,Wang YL,Osaka H,Aoki S,Wada K

doi

10.1006/bbrc.2001.4841

subject

Has Abstract

pub_date

2001-05-11 00:00:00

pages

627-33

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(01)94841-7

journal_volume

283

pub_type

杂志文章

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