An amino acid exchange in exon I of the human lecithin: cholesterol acyltransferase (LCAT) gene is associated with fish eye disease.

abstract：:We have characterized the promoter of the human gene coding for the apoferritin L subunit. Transient transfections of 5' and 3' deletion mutants indicate that the efficiency of the L promoter depends on both negative and positive cis-elements, located upstream and downstream of the transcription start point. DNaseI fo...

journal_title：Biochemical and biophysical research communications

authors： D'Agostino P,Faniello MC,Quaresima B,Bevilacqua MA,Tiano MT,Ammendola R,Cimino F,Costanzo F

更新日期：1995-10-04 00:00:00

abstract：:Two polypeptides are involved in interleukin 2 binding: a low-affinity receptor of 55 kD (IL2-R alpha) and an intermediate affinity component of 75 kD (IL2-R beta). We describe the cloning by the Polymerase Chain Reaction of the coding region of IL2-R alpha from a human T-cell lymphoma cell line. One clone presented a...

journal_title：Biochemical and biophysical research communications

authors： Mercken L,Moras V,Hemon L,Lionne B,Bousseau A,Dautry-Varsat A,Collins M,Mayaux JF

更新日期：1991-11-14 00:00:00

abstract：:Multiple deletions of mtDNA have not only been implicated in aging, but also in a wide variety of pathological conditions. The enzyme system used in long-PCR makes it possible to synthesize the entire mitochondrial genome (16.5 kb), exposing the multiple deletions in mtDNAs implicated in and, at least partially, respo...

journal_title：Biochemical and biophysical research communications

authors： Reynier P,Malthiery Y

更新日期：1995-12-05 00:00:00

abstract：:Ca2+/calmodulin-dependent protein kinases are implicated in regulating the Ca2+ signaling involved in T cell activation and in thymocyte selection. One of the earliest events in signaling through the T cell antigen receptor is activation of the protein tyrosine kinase p56lck. Following T cell activation or signaling t...

journal_title：Biochemical and biophysical research communications

authors： Bland MM,McDonald OB,Carrera AC

更新日期：1994-01-14 00:00:00

abstract：:ERK8 is the most recent addition for the MAPK family, and its mechanism of activation and function are not yet known, mainly due to the lack of any known physiological stimulator. In this report, we describe the preparation of reagents for the use of a novel method, the ligand interaction scan (LIScan), to study the f...

journal_title：Biochemical and biophysical research communications

authors： Erster O,Seger R,Liscovitch M

更新日期：2010-08-13 00:00:00

abstract：:The lipase from Malassezia globosa (SMG1) was identified to be strictly specific for mono- and diacylglycerol but not triacylglycerol. The crystal structures of SMG1 were solved in the closed conformation, but they failed to provide direct evidence of factors responsible for this unique selectivity. To address this pr...

journal_title：Biochemical and biophysical research communications

authors： Liu L,Gao C,Lan D,Yang B,Wang Y

更新日期：2012-07-27 00:00:00

abstract：:The calmodulin-like domain of calpain is important for the association of the calpain large and small subunits. We expressed the calmodulin-like domains of the large subunits of rabbit mu- and m-calpains and their small subunits in E. coli and purified them to homogeneity. Unlike the full-length subunits, the calmodul...

journal_title：Biochemical and biophysical research communications

authors： Suo S,Koike H,Sorimachi H,Ishiura S,Suzuki K

更新日期：1999-04-02 00:00:00

abstract：:This investigation of Ca2+ requirements for the mitogenic activation of lymphocytes by periodic acid has shown that oxidation by periodate causes an immediate and transient increase of Ca2+ influx and efflux in oxidized cells. Oxidized lymphocytes maintained in the medium containing 0.2 mM Ca2+ failed to proliferate o...

journal_title：Biochemical and biophysical research communications

authors： Hornicek FJ,Malinin GI,Malinin TI

更新日期：1992-02-28 00:00:00

abstract：:We have established a highly sensitive semi-nested PCR assay for the detection of H. pylori infection using gastric juice samples, which can be aspirated with disposable nasogastric tubes. The primers targeting H. pylori urease A gene were designed based on the sequence conservation analysis of sixteen H. pylori strai...

journal_title：Biochemical and biophysical research communications

authors： Kawamata O,Yoshida H,Hirota K,Yoshida A,Kawaguchi R,Shiratori Y,Omata M

更新日期：1996-02-06 00:00:00

abstract：:RNA primer removal during DNA replication is dependent on ribonucleotide- and structure-specific RNase H and FEN-1 nuclease activities. A specific RNase H involved in this reaction has long been sought. RNase HII is the only open reading frame in Archaeoglobus fulgidus genome, while multiple RNases H exist in eukaryot...

journal_title：Biochemical and biophysical research communications

authors： Chai Q,Qiu J,Chapados BR,Shen B

更新日期：2001-09-07 00:00:00

abstract：:RAB3A interacting protein (Rab3IP) has been determined to be involved in cancer progression; however, its expression pattern and function in gastric cancer remain unknown. The aim of this study was to determine the association between Rab3IP and gastric cancer, in addition to its functional role in this disease. Overe...

journal_title：Biochemical and biophysical research communications

authors： Ren H,Xu Z,Guo W,Deng Z,Yu X

更新日期：2018-09-18 00:00:00

abstract：:Estrogen induces lordosis through, in part, estrogen receptor (ER)-mediated synthesis of progesterone receptors (PR) in the ventromedial nucleus (VMN). In vitro, PR is activated by the neurotransmitter dopamine through D1-like receptors (1). In vivo, lordosis is induced by dopamine, an effect mediated in part by PR an...

journal_title：Biochemical and biophysical research communications

authors： Zhou D,Apostolakis EM,O'Malley BW

更新日期：1999-12-20 00:00:00

abstract：:Atmospheric oxygen is important for the epidermis, as the skin epidermis is not greatly affected by blood circulation. Therefore, it is necessary to understand the effect of hypoxic signals on the epidermis as some environmental stimuli can induce skin hypoxia. Here, we investigated how hypoxia (1% O2) affected skin e...

journal_title：Biochemical and biophysical research communications

authors： Park JY,Jung JY,Kim HJ,Bae IH,Kim DY,Lee TR,Shin DW

更新日期：2016-01-08 00:00:00

abstract：:We have previously reported that RhoE is overexpressed in the SGC7901/VCR cell line. However, the potential role of RhoE in the development of multidrug resistance of gastric cancer is unknown. In the present study, RhoE enhanced the resistance of SGC7901 cells to several kinds of antitumor drugs. RhoE overexpression ...

journal_title：Biochemical and biophysical research communications

authors： Li K,Lu Y,Liang J,Luo G,Ren G,Wang X,Fan D

更新日期：2009-02-06 00:00:00

abstract：:The human pregnancy-specific glycoprotein (PSG) family consists of eleven closely related molecules mainly synthesized by placental syncytiotrophoblasts and whose function(s) are unknown. They belong to the carcinoembryonic antigen (CEA) family. As a step toward understanding PSG function, we have analysed 84 PSG cDNA...

journal_title：Biochemical and biophysical research communications

authors： Teglund S,Zhou GQ,Hammarström S

更新日期：1995-06-15 00:00:00

abstract：:The tissue inhibitors of metalloproteinases (TIMPs) are specific inhibitors of MMP enzymatic activity. However, TIMP-2 can promote the activation of pro-MMP-2 by MT1-MMP. This process is mediated by the formation of a complex between MT1-MMP, TIMP-2, and pro-MMP-2. Binding of TIMP-2 to active MT1-MMP also inhibits the...

journal_title：Biochemical and biophysical research communications

authors： Hernandez-Barrantes S,Shimura Y,Soloway PD,Sang QA,Fridman R

更新日期：2001-02-16 00:00:00

abstract：:Three corticostatic peptides (GP-CS1, GP-CS2 and GP-CS3) were purified from extracts of guinea pig bone marrow. Each was identified on the basis of their ability to inhibit the secretion of corticosterone by isolated rat adrenal cells stimulated by ACTH. GP-CS1 and GP-CS2 were found to be 31 residues in length, rich i...

journal_title：Biochemical and biophysical research communications

authors： Hu J,Bennett HP,Lazure C,Solomon S

更新日期：1991-10-31 00:00:00

abstract：:Atrial- and brain-type natriuretic peptides (ANP and BNP, respectively) have been shown to exert potent lipolytic action in adipocytes. A family of natriuretic peptide receptors (NPRs), NPR-1, NPR-2, and NPR-3, mediates their physiologic effects. NPR-1 and NPR-2 are receptor guanylyl cyclases, while NPR-3 lacks enzyma...

journal_title：Biochemical and biophysical research communications

authors： Nakatsuji H,Maeda N,Hibuse T,Hiuge A,Hirata A,Kuroda Y,Kishida K,Kihara S,Funahashi T,Shimomura I

更新日期：2010-01-29 00:00:00

abstract：:Adrenomedullin (AM) gains its bioactivity by amidation at its C-terminal, forming "mature AM." The mature AM and the expression of AM receptor component mRNAs, receptor activity-modifying protein 2 and calcitonin receptor-like receptor, from feto-maternal tissues of normal pregnant women and women with histologic chor...

journal_title：Biochemical and biophysical research communications

authors： Makino I,Makino Y,Yoshihara F,Nishikimi T,Kawarabayashi T,Kangawa K,Shibata K

更新日期：2003-02-07 00:00:00

abstract：:Previously, we showed that several minor macromolecular glycolipids accounting for less than 5% of the lipoteichoic acid (LTA) fraction from Enterococcus hirae ATCC 9790 possess cytokine-inducing activity, whereas the purified LTA does not. In other words, the immunobiological activity of the LTA fraction reported in ...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto M,Imamura Y,Morichika T,Arimoto K,Takeuchi O,Takeda K,Akira S,Aoyama K,Tamura T,Kotani S,Suda Y,Kusumoto S

更新日期：2000-06-24 00:00:00

abstract：:Clinical attention to gluten-related disorders, such as celiac disease and nonceliac gluten sensitivity, is on the rise. However, identifying the pathophysiological mechanisms of gluten-related disorders remains elusive. Gliadin, a component of gluten, is known to play a major role in gluten toxicity. Caenorhabditis e...

journal_title：Biochemical and biophysical research communications

authors： Lim SD,Min H,Youn E,Kawasaki I,Shim YH

更新日期：2018-09-10 00:00:00

abstract：:A novel protein kinase activity was characterized from the cytosolic fraction of isolated rabbit gastric glands. The kinase phosphorylated a major 33,000 Da endogenous protein (pp33) and was stimulated by Zn2+ and Mn2+ with Kact of 1.0 and 7.5 mM, respectively. Mg2+ and Ca2+ failed to stimulate any pp33 kinase activit...

journal_title：Biochemical and biophysical research communications

authors： Goldenring JR,Oddsdottir M,Modlin IM

更新日期：1987-01-30 00:00:00

abstract：:SIRT3 is a NAD(+)-dependent histone deacetylaseand and plays a critical role in various human carcinomas. However, its precise role in the pathogenesis of gastric cancer (GC) is still unclear. Western blot and Real-Time PCR were used to detect the protein and mRNA level of SIRT3 in freshly collected samples from GC pa...

journal_title：Biochemical and biophysical research communications

authors： Yang B,Fu X,Shao L,Ding Y,Zeng D

更新日期：2014-01-03 00:00:00

abstract：:Tetraheme cytochrome c3 (13 kDa) and flavodoxin (16 kDa), are small electron transfer proteins that have been used to mimic, in vitro, part of the electron-transfer chain that operates between substract electron donors and respiratory electron acceptors partners in Desulfovibrio species (Palma, N., Moura, I., LeGall, ...

journal_title：Biochemical and biophysical research communications

authors： Correia C,Monzani E,Moura I,Lampreia J,Moura JJ

更新日期：1999-03-16 00:00:00

abstract：:Caspase-independent, non-apoptotic cell death is an important therapeutic target in myocardial ischemia. Leptin, an adipose-derived hormone, is known to exhibit cytoprotective effects on the ischemic heart, but the mechanisms are poorly understood. In this research, we found that pretreatment of leptin strongly suppre...

journal_title：Biochemical and biophysical research communications

authors： Takatani-Nakase T,Takahashi K

更新日期：2015-07-17 00:00:00

abstract：:The cell surface receptor integrin is involved in signaling mechanical stresses via the focal adhesion complex (FAC) into the cell. Within FAC, the focal adhesion kinase (FAK) and Pyk2 are believed to act as important scaffolding proteins. Based on the knowledge that many signal transducing molecules are transiently i...

journal_title：Biochemical and biophysical research communications

authors： Klemm AH,Kienle S,Rheinlaender J,Schäffer TE,Goldmann WH

更新日期：2010-03-19 00:00:00

abstract：:We have found that the alkyl-lysophospholipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) was able to induce apoptosis in human promyelocytic HL-60 leukemic cells, as evidenced by the internucleosomal degradation of the cellular DNA into the characteristic 180-200 bp DNA fragments. This effect was o...

journal_title：Biochemical and biophysical research communications

authors： Mollinedo F,Martínez-Dalmau R,Modolell M

更新日期：1993-04-30 00:00:00

abstract：:Thyroid hormone (T3) responsiveness of the PEPCK promoter in vivo was examined in both PEPCK/bGH(460) and PEPCK/bGH(335) mouse lines. Transgenic and non-transgenic littermates were treated with methimazole or PTU for 6 or 4 weeks, respectively, then treated +/- T3 for 10 days. In PEPCK/bGH(460) and PEPCK/bGH(355) tran...

journal_title：Biochemical and biophysical research communications

authors： Xu C,McGrane MM

更新日期：1996-01-17 00:00:00

abstract：:Intestinal organoids were recently established as an ex vivo model of the intestinal epithelium. The present study investigated the serotonin (5-hydroxytryptamine, 5-HT) system using organoids. Organoids from murine small intestinal and colonic crypts were successfully cultured. Reverse transcription-polymerase chain ...

journal_title：Biochemical and biophysical research communications

authors： Tsuruta T,Saito S,Osaki Y,Hamada A,Aoki-Yoshida A,Sonoyama K

更新日期：2016-05-20 00:00:00

abstract：:The TCP transcription factors control important aspects of plant development. Members of class I TCP proteins promote cell cycle by regulating genes directly involved in cell proliferation. In contrast, members of class II TCP proteins repress cell division. While it has been postulated that class II proteins induce d...

journal_title：Biochemical and biophysical research communications

authors： Aggarwal P,Padmanabhan B,Bhat A,Sarvepalli K,Sadhale PP,Nath U

更新日期：2011-07-01 00:00:00