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An exon 5-deleted mRNA encodes a functional interleukin 2 receptor alpha-subunit.

Abstract：

:Two polypeptides are involved in interleukin 2 binding: a low-affinity receptor of 55 kD (IL2-R alpha) and an intermediate affinity component of 75 kD (IL2-R beta). We describe the cloning by the Polymerase Chain Reaction of the coding region of IL2-R alpha from a human T-cell lymphoma cell line. One clone presented a 72-bp deletion that precisely corresponds to exon 5. The deleted form and the normal IL2-R alpha cDNA were expressed CHO cells. Stable transfected cellular clones were compared for their immunoreactivity to monoclonal antibodies directed against IL2-R alpha and for their ability to bind radiolabeled IL2. The presence or absence of the protein region encoded by exon 5 did not modify the IL2-binding capacity of the receptor.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Mercken L,Moras V,Hemon L,Lionne B,Bousseau A,Dautry-Varsat A,Collins M,Mayaux JF

doi

10.1016/s0006-291x(05)81350-6

subject

Has Abstract

pub_date

1991-11-14 00:00:00

pages

1390-5

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)81350-6

journal_volume

180

pub_type

杂志文章

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