Glucocorticoid-induced apoptosis requires FOXO3A activity.


:Dexamethasone (DEX) induces apoptosis in lymphocytes, while protecting some cancer cells from apoptosis, by a poorly understood mechanism. In this study, we examined the potential role of the forkhead transcription factor (FOXO3A) in DEX-induced apoptosis. Unphosphorylated FOXO3A, the active form of FOXO3A, can translocate into nucleus and induce apoptosis. In lymphocytes, FOXO3A is upregulated by DEX treatment, while phospho-FOXO3A was downregulated. In several different types of cancer cells, we found that sensitivity to DEX correlated negatively to expression of phospho-FOXO3A. We conclude that DEX might maintain FOXO3A in its unphosphorylated, active form. Knockdown of FOXO3A expression using a small interfering RNA (siRNA) significantly reduces apoptosis in lymphocytes. This study suggests that FOXO3A has a pivotal role in DEX-induced apoptosis. Increased phospho-FOXO3A levels in cancer cells may explain, in part, their resistance to apoptosis. Therefore, FOXO3A may be a potential target for cancer therapy.


Ma J,Xie Y,Shi Y,Qin W,Zhao B,Jin Y




Has Abstract


2008-12-19 00:00:00














  • Maillard reaction-like lysine modification by a lipid peroxidation product: immunochemical detection of protein-bound 2-hydroxyheptanal in vivo.

    abstract::2-Hydroxyheptanal (2-HH) is one of the reactive aldehyde species generated during the peroxidation of n-6 polyunsaturated fatty acids, such as linoleic and arachidonic acids. Analogous to the Maillard reaction of reducing sugars, 2-HH readily reacts with lysine epsilon-amino groups. In the present study, to define the...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Itakura K,Furuhata A,Shibata N,Kobayashi M,Uchida K

    更新日期:2003-08-29 00:00:00

  • Serum increases CYP1A1 induction by 3-methylcholanthrene.

    abstract::CYP1A1 is largely involved in carcinogenesis through the bioactivation of numerous procarcinogens. Exposure to environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) leads to induction of CYP1A1 via AhR pathway. We have previously demonstrated that fetal bovine serum (FBS) induces CYP1A1 gene transcr...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: N'Guyen QB,Fallone F,Seree E,Fina F,Villard PH,Guigal N,De Meo M,Lacarelle B,Martin PM,Barra Y

    更新日期:2002-09-20 00:00:00

  • A biological response modifier, PSK, inhibits reverse transcriptase in vitro.

    abstract::We found that PSK has an antiviral effect on human immunodeficiency virus (HIV) in vitro. One of the mechanisms of this effect is attributable to the inhibition of binding of HIV with lymphocytes. Here, we found that PSK inhibits reverse transcriptase in a non-competitive way in vitro. Such inhibition may be important...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Hirose K,Hakozaki M,Kakuchi J,Matsunaga K,Yoshikumi C,Takahashi M,Tochikura TS,Yamamoto N

    更新日期:1987-12-16 00:00:00

  • Primary structure of ovine fibroblast growth factor-1 deduced by protein and cDNA analysis.

    abstract::The amino acid sequence of full-length ovine fibroblast growth factor-1 (FGF-1) was determined by a combination of protein and cDNA sequencing. FGF-1 cDNA analysis indicated that ovine kidney cells express mRNAs encoding both full-length FGF-1 and a truncated FGF-1 variant. An overall comparison of the ovine FGF-1 pri...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Grieb TW,Ring M,Brown E,Palmer C,Belle N,Donjerkovic D,Chang H,Yun J,Subramanian R,Forozan F,Guo Y,Vertes A,Winkles JA,Burgess WH

    更新日期:1998-05-08 00:00:00

  • 8-azaguanosine-5'-monophosphate synthesis via nucleoside kinase in cultured Chinese hamster lung fibroblasts.

    abstract::Cultured chinese hamster lung fibroblasts, and a variant clone selected for resistance to 8-azaguanine, that lacks hypoxanthine-guanine phosphoribosyl transferase (EC, have been tested for the ability to convert 8-azaguanine into 8-azaguanosine-5'-monophosphate via purine nucleoside phosphorylase and nucleosi...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Tozzi MG,Camici M,Falcone V,Turriani M,Turchi G,Ipata PL

    更新日期:1989-03-15 00:00:00

  • The CYP P450 arachidonic acid monooxygenases: from cell signaling to blood pressure regulation.

    abstract::The studies of the cytochrome P450 (P450) arachidonic acid (AA) monooxygenase, now established as a major pathway for the bioactivation of AA, have uncovered new and important functional roles for this enzyme system in cell and organ physiology, and in the metabolism of endogenous substrate. Past and present advances ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章,评审


    authors: Capdevila JH,Falck JR

    更新日期:2001-07-20 00:00:00

  • Gamma-glutamyltranspeptidase-dependent glutathione catabolism results in activation of NF-kB.

    abstract::gamma-glutamyltranspeptidase (GGT) is a key enzyme implicated in the homeostasis of intracellular reduced glutathione (GSH) and hence in the regulation of the cellular redox state. Besides, the extracellular cleavage of GSH by GGT leads to reactive oxygen species (ROS) production, depending on the generation and enhan...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Accaoui MJ,Enoiu M,Mergny M,Masson C,Dominici S,Wellman M,Visvikis A

    更新日期:2000-10-05 00:00:00

  • Toxoplasma gondii exposes phosphatidylserine inducing a TGF-beta1 autocrine effect orchestrating macrophage evasion.

    abstract::Toxoplasmosis is a worldwide disease caused by Toxoplasma gondii. Activated macrophages control T. gondii growth by nitric oxide (NO) production. However, T. gondii active invasion inhibits NO production, allowing parasite persistence. Here we show that the mechanism used by T. gondii to inhibit NO production persisti...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Seabra SH,de Souza W,Damatta RA

    更新日期:2004-11-12 00:00:00

  • A monoclonal antibody against acetylcholinesterase inhibits the formation of amyloid fibrils induced by the enzyme.

    abstract::A monoclonal antibody (mAb) 25B1 directed against fetal bovine-serum acetylcholinesterase (FBS AChE) was used to examine the ability of the cholinergic enzyme to promote the assembly of amyloid-beta peptides (A beta) into Alzheimerś fibrils. This mAb binds to the peripheral anionic site of the enzyme and allostericall...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Reyes AE,Perez DR,Alvarez A,Garrido J,Gentry MK,Doctor BP,Inestrosa NC

    更新日期:1997-03-27 00:00:00

  • Up-regulated expression of beta3 integrin induced by dengue virus serotype 2 infection associated with virus entry into human dermal microvascular endothelial cells.

    abstract::Permeability alteration of microvascular endothelia is a factor in the plasma leakage produced by dengue virus (DV) infection, and beta3 integrin plays central roles in maintaining capillary integrity and regulating vascular permeability. In this study, interaction between beta3 integrin and DV serotype 2 (DV2) was in...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Zhang JL,Wang JL,Gao N,Chen ZT,Tian YP,An J

    更新日期:2007-05-11 00:00:00

  • The effect of the mtDNA4834 deletion on hearing.

    abstract::Mutations in mitochondrial DNA (mtDNA) are associated with diverse pathological states in humans, notably sensorineural deafness. In humans, mtDNA4977 deletion, known as common deletion, is thought to play a critical role in presbyacusis. A similar mtDNA deletion occurs in the naturally aging rats is mtDNA4834 deletio...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kong WJ,Hu YJ,Wang Q,Wang Y,Han YC,Cheng HM,Kong W,Guan MX

    更新日期:2006-05-26 00:00:00

  • Induction of endothelin-converting enzyme-1 in gastric mucosal injury by idomethacin.

    abstract::Endothelin-1 (ET-1) is a 21-amino acid vasoactive peptide produced from a 39-amino acid biologically inactive peptide, big ET-1, by the action of endothelin-converting enzyme-1 (ECE-1). We investigated gastric mucosal expression of ECE-1 during a 16 h course of inflammatory responses associated with gastric mucosal in...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Slomiany BL,Slomiany A

    更新日期:2000-03-16 00:00:00

  • Baculovirus-mediated high level expression of a mammalian DNA methyltransferase.

    abstract::The murine C-5 cytosine DNA methyltransferase (MTase, E.C. containing a hexahistidine affinity leader peptide has been expressed at levels which are at least 50-fold higher than previously reported. The recombinant enzyme has activity levels similar to the wild-type enzyme. The recombinant polypeptide binds t...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Glickman JF,Reich NO

    更新日期:1994-11-15 00:00:00

  • Characterization of the platelet-derived growth factor beta-receptor kinase activity by use of synthetic peptides.

    abstract::Synthetic peptides derived from the sequence surrounding tyrosine-857 in the human platelet-derived growth factor (PDGF) beta-receptor were used to elucidate the requirement for length and presence of negative and positively charged amino acids in substrates of the PDGF beta-receptor protein tyrosine kinase. The measu...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Rönnstrand L,Sorokin A,Engström U,Heldin CH

    更新日期:1990-03-30 00:00:00

  • Disruption of behavioral circadian rhythms induced by psychophysiological stress affects plasma free amino acid profiles without affecting peripheral clock gene expression in mice.

    abstract::Disordered circadian rhythms are associated with various psychiatric conditions and metabolic diseases. We recently established a mouse model of a psychophysiological stress-induced chronic sleep disorder (CSD) characterized by reduced amplitude of circadian wheel-running activity and sleep-wake cycles, sleep fragment...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Oishi K,Yamamoto S,Itoh N,Miyazaki K,Nemoto T,Nakakita Y,Kaneda H

    更新日期:2014-07-18 00:00:00

  • Identification and cloning of two novel allergens from the lipophilic yeast, Malassezia furfur.

    abstract::Two novel allergens, designated Mal f 2 and Mal f 3 according to the WHO/IUIS Allergen Nomenclature Subcommittee recommendation, were isolated from the lipophilic yeast Malassezia furfur cell extracts and the genes coding for those were cloned. Mal f 2 and Mal f 3 had apparent molecular weights of 21 kDa and 20 kDa, r...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Yasueda H,Hashida-Okado T,Saito A,Uchida K,Kuroda M,Onishi Y,Takahashi K,Yamaguchi H,Takesako K,Akiyama K

    更新日期:1998-07-20 00:00:00

  • Inhibition of the formation of the neurotoxin 5-S-cysteinyl-dopamine by polyphenols.

    abstract::The death of nigral neurons in Parkinson's disease is thought to involve the formation of the endogenous neurotoxin, 5-S-cysteinyl-dopamine. In the present study, we show that the polyphenols, (+)-catechin and caffeic acid, which contain a catechol moiety, inhibit tyrosinase-induced formation of 5-S-cysteinyl-dopamine...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Vauzour D,Vafeiadou K,Spencer JP

    更新日期:2007-10-19 00:00:00

  • Cell cycle regulation of the BRCA1/acetyl-CoA-carboxylase complex.

    abstract::Germ-line alterations in BRCA1 are associated with an increased susceptibility to breast and ovarian cancer. The BRCA1 protein has been implicated in multiple cellular functions. We have recently demonstrated that BRCA1 reduces acetyl-CoA-carboxylase alpha (ACCA) activity through its phospho-dependent binding to ACCA,...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Ray H,Suau F,Vincent A,Dalla Venezia N

    更新日期:2009-01-16 00:00:00

  • Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein.

    abstract::Aurora-C, a member of the Aurora kinase family, is implicated in the regulation of mitosis. In contrast to Aurora-A and Aurora-B its cellular localization and functions are poorly characterized. TACC1 protein belongs to the transforming acidic coiled-coil family shown to interact with the Aurora kinases. In the presen...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Gabillard JC,Ulisse S,Baldini E,Sorrenti S,Cremet JY,Coccaro C,Prigent C,D'Armiento M,Arlot-Bonnemains Y

    更新日期:2011-05-20 00:00:00

  • New method to differentiate human peripheral blood monocytes into insulin producing cells: Human hematosphere culture.

    abstract::Strategy to differentiate stem cells into insulin producing cells (IPCs) in vitro has been a promising one to get cell source of β-cell replacement therapy for diabetes. It has been suggested that islets and neurons share features and nestin-positive cells could differentiate into IPCs. We have recently developed a th...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Hur J,Yang JM,Choi JI,Yun JY,Jang JH,Kim J,Kim JY,Oh IY,Yoon CH,Cho HJ,Park YB,Kim HS

    更新日期:2012-02-24 00:00:00

  • Activation of metabotropic glutamate receptor 5 reduces the secondary brain injury after traumatic brain injury in rats.

    abstract::A wealth of evidence has shown that microglia-associated neuro-inflammation is involved in the secondary brain injury contributed to the poor outcome after traumatic brain injury (TBI). In vitro studies were reported that activation of metabotropic glutamate receptor 5 (mGluR5) could inhibit the microglia-associated i...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Wang JW,Wang HD,Cong ZX,Zhang XS,Zhou XM,Zhang DD

    更新日期:2013-01-18 00:00:00

  • Direct evidence that the brain reward system is involved in the control of scratching behaviors induced by acute and chronic itch.

    abstract::In the present study, we demonstrated that there is a direct relationship between scratching behaviors induced by itch and functional changes in the brain reward system. Using a conditional place preference test, the rewarding effect was clearly evoked by scratching under both acute and chronic itch stimuli. The induc...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Setsu T,Hamada Y,Oikawa D,Mori T,Ishiuji Y,Sato D,Narita M,Miyazaki S,Furuta E,Suda Y,Sakai H,Ochiya T,Tezuka H,Iseki M,Inada E,Yamanaka A,Kuzumaki N,Narita M

    更新日期:2021-01-01 00:00:00

  • A point mutation in a plasma membrane Ca(2+)-ATPase gene causes deafness in Wriggle Mouse Sagami.

    abstract::The spontaneous mutant, Wriggle Mouse Sagami (wri), is thought to be a model of hereditary hearing losses in humans. Here we report that the plasma membrane Ca(2+)-ATPase type 2 (PMCA2) gene is mutated in the wri mouse. A G-to-A transition was detected in wri, changing Glu-to-Lys within a conserved transmembrane domai...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Takahashi K,Kitamura K

    更新日期:1999-08-11 00:00:00

  • Synthesis and biological properties of antiparallel and parallel dimers of alpha-human atrial natriuretic peptide.

    abstract::To obtain antiparallel and parallel dimers of alpha-human atrial natriuretic peptide (alpha-hANP), two fully protected peptides I and II having the same amino acid sequence as alpha-hANP with different protective groups at the cysteinyl residues were synthesized, the former having Acm and Npys and the latter MeBzl and...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Chino N,Yoshizawa-Kumagaye K,Noda Y,Watanabe TX,Kimura T,Sakakibara S

    更新日期:1986-12-15 00:00:00

  • Inhibin and beta type transforming growth factor (TGF beta) have opposite modulating effects on the follicle stimulating hormone (FSH)-induced aromatase activity of cultured rat granulosa cells.

    abstract::We have recently observed that attomolar concentration of exogenously added TGF beta, a molecule structurally related to inhibin, can stimulate the basal secretion of FSH in a pituitary cell culture. Inhibin purified from porcine follicular fluid antagonizes this activity of TGF beta. To understand further the homeost...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Ying SY,Becker A,Ling N,Ueno N,Guillemin R

    更新日期:1986-05-14 00:00:00

  • Functional characterization of the Arabidopsis universal stress protein AtUSP with an antifungal activity.

    abstract::An antifungal protein, AtUSP protein (At3g53990), was isolated from Arabidopsis thaliana leaves by ion and size chromatography and sequenced by N-terminal sequencing. The AtUSP gene amplified from an Arabidopsis leaf cDNA library was transformed to Escherichia coli to express the AtUSP protein. The recombinant protein...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Park SC,Jung YJ,Lee Y,Kim IR,Seol MA,Kim EJ,Jang MK,Lee JR

    更新日期:2017-05-13 00:00:00

  • Altered cAMP levels in retinas from transgenic mice expressing a rhodopsin mutant.

    abstract::Transgenic mice expressing the rhodopsin mutant Pro347Ser (Serine 6) display retinal degeneration through apoptosis that is characteristic of the disease retinitis pigmentosa. By 5 weeks after birth, these mice have lost approximately 35% of their photoreceptor cells. Retinas from these mice showed higher levels of cA...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Weiss ER,Hao Y,Dickerson CD,Osawa S,Shi W,Zhang L,Wong F

    更新日期:1995-11-22 00:00:00

  • Evidence for an inactive plasma membrane-associated precursor of active cytoplasmic ornithine decarboxylase in developing embryos of Musca domestica.

    abstract::During embryonic development of Musca domestica inactive ornithine decarboxylase protein appears in the embryos at 6 h postoviposition, increases in concentration and reaches a maximum level at 9 h postoviposition. The inactive enzyme is associated with the plasma membrane and appears to be the precursor for active or...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Lilleberg SL,Killilea SD,Vaske DA,Leopold RA,Sparks RB Jr

    更新日期:1991-01-31 00:00:00

  • The metal-mediated formation of hydroxyl radical by aqueous extracts of cigarette tar.

    abstract::Aqueous extracts of cigarette tar produce hydroxyl radicals that are spin trapped by 5,5-dimethyl-1-pyrroline-N-oxide. The addition of catalase almost completely inhibits and superoxide dismutase partially inhibits spin adduct formation. The addition of ethylenediamine tetraacetic acid greatly increases the amount of ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Cosgrove JP,Borish ET,Church DF,Pryor WA

    更新日期:1985-10-15 00:00:00

  • Comparative interactome analysis reveals distinct and overlapping properties of Raf family kinases.

    abstract::The three mammalian Raf proteins (A-Raf, B-Raf, and C-Raf) are key components of the MAPK pathway. Although diverse functions have been proposed for Raf kinases, it is still not clear how interacting proteins contribute to differences in the signaling functions of the three Raf kinases. Here, we report the comparative...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Zhang XY,Guo H,Huang Y,Hao PQ,Yang Y,Liu Y,Guo XX,Hao Q,An S,Xu TR

    更新日期:2019-07-05 00:00:00