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Modulation of autonomic neuroeffector transmission by nitric oxide in guinea pig ileum.

Abstract：

:NG-monomethyl-L-arginine (L-NMMA), an inhibitor of nitric oxide synthesis, markedly enhanced tonic ("hump") responses to transmural stimulation in guinea pig ileum longitudinal muscle. The enhancement of the hump responses was probably due to a prejunctional effect on substance P-like neurotransmission, since the action of L-NMMA was exerted also in the presence of atropine, and since responses to substance P, a mimic of nerve stimulation, were unaffected by L-NMMA as were cholinergic twitch responses and the overflow of [3H]choline. Further in support, the hump responses were blocked by the substance P antagonist Spantide. All effects of L-NMMA were stereospecifically reversed by L-arginine. Endogenous nitric oxide thus selectively modulates peptidergic neurotransmission in the gut.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Gustafsson LE,Wiklund CU,Wiklund NP,Persson MG,Moncada S

doi

10.1016/s0006-291x(05)81028-9

subject

Has Abstract

pub_date

1990-11-30 00:00:00

pages

106-10

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)81028-9

journal_volume

173

pub_type

杂志文章

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