Sulforaphane induced adipolysis via hormone sensitive lipase activation, regulated by AMPK signaling pathway.

abstract：:Isolated nuclei from mammalian cells contain a Ca(2+)-dependent endonuclease [1]. The produced DNA fragmentation is a necessary step in the sequence of events resulting in apoptosis [2]. We report here that zinc inhibits the DNA fragmentation in dependence of the free Ca2+ concentrations, suggesting that a balance bet...

journal_title：Biochemical and biophysical research communications

authors： Lohmann RD,Beyersmann D

更新日期：1993-02-15 00:00:00

abstract：:The efficacy of gamma-guanidinooxypropylamine (GAPA), a novel agmatine analogue against protozoan parasite, Leishmaniadonovani was evaluated. Wild-type and ornithine decarboxylase-overexpressors of L. donovani were used to study the effect and mode of action of this inhibitor. GAPA inhibited the growth of both promast...

journal_title：Biochemical and biophysical research communications

authors： Singh S,Jhingran A,Sharma A,Simonian AR,Soininen P,Vepsalainen J,Khomutov AR,Madhubala R

更新日期：2008-10-10 00:00:00

abstract：:Recent evidence suggests that untimely retinoblastoma protein (RB) dephosphorylation and/or proteolytic degradation might provide key events down-stream cysteine protease (caspase) activation in apoptosis induction. We have dealt with this issue by studying apoptosis induced by N-hexanoylsphingosine (C6-Cer) in CHP-10...

journal_title：Biochemical and biophysical research communications

authors： Spinedi A,Amendola A,Di Bartolomeo S,Piacentini M

更新日期：1998-02-24 00:00:00

abstract：:Model-free approaches (error-prone PCR to introduce random mutations, DNA shuffling to combine positive mutations, and screening of the resultant mutant libraries) have been used to enhance the catalytic activity and thermostability of alpha-aspartyl dipeptidase from Salmonella typhimurium, which is uniquely able to h...

journal_title：Biochemical and biophysical research communications

authors： Kong X,Liu Y,Gou X,Zhu S,Zhang H,Wang X,Zhang J

更新日期：2001-11-23 00:00:00

abstract：:Calreticulin has multiple functions, diverse cellular locations, and putative isoforms. It likely maintains integrin avidity by binding alpha integrin cytoplasmic tails and is a surface lectin which triggers cell spreading. In the present study, we have immunocaptured a cell surface complex from B16 mouse melanoma cel...

journal_title：Biochemical and biophysical research communications

authors： Zhu Q,Zelinka P,White T,Tanzer ML

更新日期：1997-03-17 00:00:00

abstract：:The oyster vasa-like gene was previously demonstrated to be specifically expressed in germline cells of adult oysters Crassostrea gigas. In the present study, this gene was used as a molecular marker to establish the developmental pattern of germline cells during oyster ontogenesis, using whole-mount in situ hybridiza...

journal_title：Biochemical and biophysical research communications

authors： Fabioux C,Huvet A,Lelong C,Robert R,Pouvreau S,Daniel JY,Minguant C,Le Pennec M

更新日期：2004-07-23 00:00:00

abstract：:As many structurally diverse chemicals have been reported to function as estrogens, evaluations for estrogenicity of compounds are of widespread concern. Recently, we identified WISP-2 (Wnt-1 inducible signaling pathway protein 2) as a novel estrogen-inducible gene in human breast cancer cells. In this study, we exami...

journal_title：Biochemical and biophysical research communications

authors： Inadera H,Dong HY,Matsushima K

更新日期：2002-06-14 00:00:00

abstract：:The Vpr protein of human immunodeficiency virus type 1 (HIV-1) is incorporated into the virion by the Gag polyprotein precursor Pr55gag. The importance of the p6gag sequence at the C-terminal end of Pr55gag has a crucial role in Vpr incorporation. To identify the Gag sequences directly involved in Vpr binding, we comp...

journal_title：Biochemical and biophysical research communications

authors： Li MS,Garcia-Asua G,Bhattacharyya U,Mascagni P,Austen BM,Roberts MM

更新日期：1996-01-05 00:00:00

abstract：:RNA polymerase III promoters of human ribonuclease P RNA component H1, human U6, and mouse U6 small nuclear RNA genes are commonly used in short hairpin RNA (shRNA) expression vectors due their precise initiation and termination sites. During transient transfection of shRNA vectors, we observed that H1 or U6 promoters...

journal_title：Biochemical and biophysical research communications

authors： Rumi M,Ishihara S,Aziz M,Kazumori H,Ishimura N,Yuki T,Kadota C,Kadowaki Y,Kinoshita Y

更新日期：2006-01-13 00:00:00

abstract：:A number of growth factors can maintain hormonally-responsive epithelium in murine mammary explants as well as insulin, but only insulin can promote the synthesis of casein and alpha-lactalbumin, in the presence of glucocorticoid and prolactin. Anti-insulin receptor serum can elicit these effects of insulin on milk pr...

journal_title：Biochemical and biophysical research communications

authors： Nicholas KR,Topper YJ

更新日期：1983-03-29 00:00:00

abstract：:Interleukin-17 is a T-cell-derived pro-inflammatory cytokine, exhibiting multiple biological activities in a variety of cells and believed to fine tune all general phases of hematopoietic response. However, the signaling mechanism of this novel cytokine remains unknown. Here, we report for the first time that the earl...

journal_title：Biochemical and biophysical research communications

authors： Subramaniam SV,Cooper RS,Adunyah SE

更新日期：1999-08-19 00:00:00

abstract：:Pulse labeling followed by SDS-PAGE electrophoresis of immunoprecipitated [35S]methionine-labeled steroid sulfatase (STS) gave a single band of molecular weight 65,000 daltons. After a chase period of 18 hours the material appeared as molecular weight approximately 64,000. No labeled STS could be detected in fibroblas...

journal_title：Biochemical and biophysical research communications

authors： Horwitz AL,Warshawsky L,King J,Burns G

更新日期：1986-03-13 00:00:00

abstract：:We report the results of a pilot study to determine the feasibility of using PCR random mutagenesis and in vitro transcription/translation to produce protease resistant full-length or truncated ovine prion proteins (PrP). Using this approach, we show the novel production of protease resistant recombinant ovine prion p...

journal_title：Biochemical and biophysical research communications

authors： Dear DV,Fitzmaurice TJ,Garton S,Richards SJ

更新日期：2001-03-09 00:00:00

abstract：:The senescence-accelerated mouse prone 8 (SAMP8) strain exhibits age-related learning and memory deficits (LMD) at 2 months of age. Combined linkage analysis of 264 F2 intercross SAMP8 × JF1 mice and RNA-seq analysis identified Hcn1 gene out of 29 genes in the LMD region on chromosome 13. Hcn1 in SAMP8 strain showed 1...

journal_title：Biochemical and biophysical research communications

authors： Akbor MM,Tomobe K,Yamada T,Kim J,Mano H,Kurosawa N,Sasaki K,Nomura Y,Isobe M

更新日期：2013-11-08 00:00:00

abstract：:The development of head and neck squamous cell carcinoma (HNSCC) is a complex pathological process and many cellular and molecular events may occur. The ubiquitin conjugating enzyme E2 (UBE2C) was found to play an oncogenic role in several human cancers. However, its functional role in HNSCC tumorigenesis remains unkn...

journal_title：Biochemical and biophysical research communications

authors： Jin Z,Zhao X,Cui L,Xu X,Zhao Y,Younai F,Messadi D,Hu S

更新日期：2020-03-05 00:00:00

abstract：:Intestinal challenge with cholera toxin induces the synthesis of a hormone-like protein which counteracts intestinal hypersecretion. This study shows that the protein also inhibits GABA transport across the plasma membrane of Deiters' cells in rabbits. The inhibitory action of the protein was dose dependent, and 10(3)...

journal_title：Biochemical and biophysical research communications

authors： Lange S,Lönnroth I,Palm A,Hydén H

更新日期：1985-08-15 00:00:00

abstract：:Ligands of the glial cell line-derived neurotrophic factors (GDNF)-family are trophic factors for the development and survival of multiple cell types, however their effects on non-neuronal stem cells are unknown. We examined the action of neurturin on a candidate stem cell population isolated from adult skeletal muscl...

journal_title：Biochemical and biophysical research communications

authors： Vourc'h P,Lacar B,Mignon L,Lucas PA,Young HE,Chesselet MF

更新日期：2005-06-24 00:00:00

abstract：:The fibroblast growth factors (FGFs) play important roles in morphogenesis, angiogenesis, tissue remodeling, and carcinogenesis. Human FGF-20 has been cloned and characterized in this study. FGF-20 encodes a 211-amino-acid polypeptide with the FGF-core domain. A strong hydrophobic region was found in the FGF-core doma...

journal_title：Biochemical and biophysical research communications

authors： Kirikoshi H,Sagara N,Saitoh T,Tanaka K,Sekihara H,Shiokawa K,Katoh M

更新日期：2000-08-02 00:00:00

abstract：:In order to study the relationship between insulin like growth factor-II (IGF-II) and interleukin-8 (IL-8) that are upregulated in psoriasis, we monitored IL-8 expression in IGF-II-treated human keratinocytes and explored the signaling pathways of IL-8 expression by IGF-II. IGF-II increased the IL-8 mRNA and protein l...

journal_title：Biochemical and biophysical research communications

authors： Kim HJ,Byun SJ,Kim TY

更新日期：2004-04-23 00:00:00

abstract：:Tropomyosins are a family of actin binding proteins encoded by a group of highly conserved genes. Humans have four tropomyosin-encoding genes: TPM1, TPM2, TPM3, and TPM4, each of which is known to generate multiple isoforms by alternative splicing, promoters, and 3' end processing. TPM1 is the most versatile and encod...

journal_title：Biochemical and biophysical research communications

authors： Denz CR,Narshi A,Zajdel RW,Dube DK

更新日期：2004-08-06 00:00:00

abstract：:Activation of seven-transmembrane G-protein coupled receptor (GPCR) mediates extracellular signals into intracellular responses. G-protein coupled receptor 55 (GPR55) is one of GPCRs and activated by endogenous cannabinoids. A family of regulators of G-protein signaling (RGS) stimulates GTP hydrolysis of alpha subunit...

journal_title：Biochemical and biophysical research communications

authors： Jang H,Kim Y,Ghil S

更新日期：2020-12-17 00:00:00

abstract：:The circular RNA (circRNA) circEPSTI1 has been recently identified as a new cancer-associated circRNA in multiple types of cancer. However, the involvement of circEPSTI1 in non-small cell lung cancer (NSCLC) remains unexplored. The purpose of this study was to explore the expression pattern and function of circEPSTI1 ...

journal_title：Biochemical and biophysical research communications

authors： Yang T,Li M,Li H,Shi P,Liu J,Chen M

更新日期：2020-09-10 00:00:00

abstract：:During embryonic development of Musca domestica inactive ornithine decarboxylase protein appears in the embryos at 6 h postoviposition, increases in concentration and reaches a maximum level at 9 h postoviposition. The inactive enzyme is associated with the plasma membrane and appears to be the precursor for active or...

journal_title：Biochemical and biophysical research communications

authors： Lilleberg SL,Killilea SD,Vaske DA,Leopold RA,Sparks RB Jr

更新日期：1991-01-31 00:00:00

abstract：:RNA interference (RNAi) mediated inhibition of virus-specific genes has emerged as a potential therapeutic strategy against virus induced diseases. Human hepatitis B virus (HBV) surface antigen (HBsAg) has proven to be a significant risk factor in HBV induced liver diseases, and an increasing number of mutations in HB...

journal_title：Biochemical and biophysical research communications

authors： Cheng TL,Chang WW,Su IJ,Lai MD,Huang W,Lei HY,Chang WT

更新日期：2005-10-28 00:00:00

abstract：:The aromatic l-alpha-hydroxy acid dehydrogenase (AHDAH) from Trypanosoma cruzi has over 50% sequence identity with cytosolic malate dehydrogenases (cMDHs), yet it is unable to reduce oxaloacetate. Molecular modeling of the three-dimensional structure of AHADH using the pig cMDH as template directed the construction of...

journal_title：Biochemical and biophysical research communications

authors： Vernal J,Fiser A,Sali A,Müller M,Cazzulo JJ,Nowicki C

更新日期：2002-04-26 00:00:00

abstract：:Brewers yeast contains factors that increase and decrease glucose tolerance. Hop components (lupulones) that adhere to yeast during the brewing process elicit a variety of biological effects including the induction of hepatic cytochrome P4503A. Colupulone was tested for its effects on glucose tolerance and cytochrome ...

journal_title：Biochemical and biophysical research communications

authors： Mannering GJ,Shoeman JA,Shoeman DW

更新日期：1994-05-16 00:00:00

abstract：:The methionine sulfoxide reductase (Msr) family of enzymes has been shown to protect cells against oxidative damage. The two major Msr enzymes, MsrA and MsrB, can repair oxidative damage to proteins due to reactive oxygen species, by reducing the methionine sulfoxide in proteins back to methionine. A role of MsrA in a...

journal_title：Biochemical and biophysical research communications

authors： Cudic P,Joshi N,Sagher D,Williams BT,Stawikowski MJ,Weissbach H

更新日期：2016-01-22 00:00:00

abstract：:Apolipoprotein E-knockout (ApoE(-/-)) mice, atherosclerosis-prone mice, show an autoimmune response, but the pathogenesis is not fully understood. We investigated the pathogenesis in female and male ApoE(-/-) mice. The spleens of all ApoE(-/-) and C57BL/6 (B6) mice were weighed. The serum IgG level and titers of anti-...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Huang Z,Lu H,Lin H,Wang Z,Chen X,Ouyang Q,Tang M,Hao P,Ni J,Xu D,Zhang M,Zhang Q,Lin L,Zhang Y

更新日期：2012-07-13 00:00:00

abstract：:Phage displayed peptide library was used to select tumor necrosis factor alpha (TNFalpha) binding peptides. After three sequential rounds of biopanning, some linear TNFalpha-binding peptides were identified from a 12-mer peptide library. A consensus sequence (L/M)HEL(Y/F)(L/M)X(W/Y/F), where X might be variable residu...

journal_title：Biochemical and biophysical research communications

authors： Zhang J,Zheng L,Zhao A,Gao B,Liu NL,Wang F,Dong J,Xin ZT,Shao NS,Wang HX,Xue YN

更新日期：2003-10-31 00:00:00

abstract：:Calcineurin (CN), a calcium-activated phosphatase, plays a critical role in various biological processes including T cell activation. Cabin1, a calcineurin binding protein 1, has been shown to bind directly to CN using its C-terminal region and inhibit CN activity. However, no increase in CN activity has been found in...

journal_title：Biochemical and biophysical research communications

authors： Jang H,Cho EJ,Youn HD

更新日期：2007-07-20 00:00:00