WISP-2 is a secreted protein and can be a marker of estrogen exposure in MCF-7 cells.

abstract：:Antitrypsin was resolved into two pools by ion-exchange chromatography. Pool 2 contained three anodal isoinhibitors and an N-terminal sequence identical with the one found by others. Pool 1 contained, in addition to the anodal ones two cathodal isoinhibitors as well. The sequencing data of Pool 1 indicate that the cat...

journal_title：Biochemical and biophysical research communications

authors： Hercz A

更新日期：1985-04-16 00:00:00

abstract：:Neuropilin-1 (NRP-1) is involved in angiogenesis, but the role of NRP-1 in megakaryocytopoiesis is not yet fully understood. In this study, we investigated whether thrombopoietin (TPO) regulates the expression of platelet-derived growth factor (PDGF) and its receptors (PDGFRs) on TPO-dependent UT-7/TPO cells and wheth...

journal_title：Biochemical and biophysical research communications

authors： Ohsaka A,Hirota-Komatsu S,Araki M,Komatsu N

更新日期：2015-04-10 00:00:00

abstract：:This study tests the hypothesis that articular chondrocytes shift from a characteristically glycolytic to an oxidative energy metabolism during population expansion in monolayer. Bovine articular chondrocytes were cultured in monolayer under standard incubator conditions for up to 14 days. Cellular proliferation, oxyg...

journal_title：Biochemical and biophysical research communications

authors： Heywood HK,Lee DA

更新日期：2008-08-22 00:00:00

abstract：:Neural crest cells originating from the posterior rhombencephalon migrate to the cardiac outflow tract and participate in division of the aorta and pulmonary trunk. Ablation of this region of premigratory neural crest in the chick embryos results in nondivision of the outflow vessels. Subtractive hybridization was use...

journal_title：Biochemical and biophysical research communications

authors： Kirby ML,Cheng G,Stadt H,Hunter G

更新日期：1995-07-17 00:00:00

abstract：:Erythropoietin (EPO) has been known to have cytoprotective effects on several types of tissues, presumably through modulation of apoptosis and inflammation. The effect of EPO on myocardial inflammation, however, has not yet been clarified. We investigated the cardioprotective effects of EPO in rats with experimental a...

journal_title：Biochemical and biophysical research communications

authors： Mitsuma W,Ito M,Kodama M,Fuse K,Okamura K,Minagawa S,Kato K,Hanawa H,Toba K,Nakazawa M,Aizawa Y

更新日期：2006-06-09 00:00:00

abstract：:Using an oligonucleotide hybridization assay to gain insight into the folding of delta ribozymes, we demonstrate a correlation between their folding and catalytic behavior. Together with recent structural information on the crystal structure of self-cleaved genomic delta ribozyme, in which the L3 loop interacts with J...

journal_title：Biochemical and biophysical research communications

authors： Ananvoranich S,Perreault JP

更新日期：2000-04-13 00:00:00

abstract：:Synucleinopathies such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA) are defined by the presence of intracellular alpha-synuclein aggregates in neurons and/or oligodendrocytes. In addition, post mortem tissue analysis revealed profound changes in microglial morphology,...

journal_title：Biochemical and biophysical research communications

authors： Hoffmann A,Ettle B,Bruno A,Kulinich A,Hoffmann AC,von Wittgenstein J,Winkler J,Xiang W,Schlachetzki JCM

更新日期：2016-10-28 00:00:00

abstract：:The EC(50) values for concentration-dependent stimulation of cAMP accumulation by CRF (1.3nM) and urocortin (1.0nM) were equivalent in human retinoblastoma Y79 cells. The time course and magnitude of CRF- and urocortin-induced CRF(1) receptor desensitization were similar. A significant 3-fold increase in GRK3, but not...

journal_title：Biochemical and biophysical research communications

authors： Dautzenberg FM,Wille S,Braun S,Hauger RL

更新日期：2002-11-01 00:00:00

abstract：:Model-free approaches (error-prone PCR to introduce random mutations, DNA shuffling to combine positive mutations, and screening of the resultant mutant libraries) have been used to enhance the catalytic activity and thermostability of alpha-aspartyl dipeptidase from Salmonella typhimurium, which is uniquely able to h...

journal_title：Biochemical and biophysical research communications

authors： Kong X,Liu Y,Gou X,Zhu S,Zhang H,Wang X,Zhang J

更新日期：2001-11-23 00:00:00

abstract：:Therapeutic efficacy of a synthetic somatostatin analogue for the treatment of carcinoid tumors is still controversial. In vivo studies performed in our laboratory showed that a somatostatin analogue, SMS 201-995, significantly inhibited growth of human pancreatic carcinoid (BON) tumors xenotransplanted into athymic n...

journal_title：Biochemical and biophysical research communications

authors： Ishizuka J,Beauchamp RD,Evers BM,Townsend CM Jr,Thompson JC

更新日期：1992-06-15 00:00:00

abstract：:Phosphofructokinase (PFK) from human polymorphonuclear leukocytes (PMN) was characterized by immunological titration with subunit specific antibodies, column chromatography on QAE-Sephadex and SDS-polyacrylamide gel electrophoresis. Two different isozymes, M-type and L-type, were found. The M(r) values of the M and L ...

journal_title：Biochemical and biophysical research communications

authors： Durante P,Raleigh X,Gómez ME,Campos G,Ryder E

更新日期：1995-11-22 00:00:00

abstract：:Changes in phospholipid and fatty acid profile are hallmarks of cancer progression. Increase in peripheral benzodiazepine receptor expression has been implicated in breast cancer. The benzodiazepine, Ro5-4864, increases cell proliferation in some breast cancer cell lines. Biosynthesis of phosphatidylcholine (PC) has b...

journal_title：Biochemical and biophysical research communications

authors： Akech J,Sinha Roy S,Das SK

更新日期：2005-07-22 00:00:00

abstract：:This study aims to investigate the clinical significance and biological function of RASSF6 in human breast cancers. RASSF6 protein was found to be downregulated in 42 of 95 human breast cancer tissues by immunohistochemistry, which was associated with advanced TNM stage and nodal metastasis. The rate of RASSF6 downreg...

journal_title：Biochemical and biophysical research communications

authors： He Z,Zhao TT,Jin F,Li JG,Xu YY,Dong HT,Liu Q,Xing P,Zhu GL,Xu H,Miao ZF

更新日期：2018-09-18 00:00:00

abstract：:Primary mouse embryo fibroblasts passed in culture go through a period of declining growth rate and then after a period of minimal proliferation begin to grow again, generating, under appropriate conditions, an immortal 3T3 line. The 3T3 cells, but not the primary mouse embryo fibroblasts, are able to synthesize and t...

journal_title：Biochemical and biophysical research communications

authors： Edwards DR,Parfett CL,Smith JH,Denhardt DT

更新日期：1987-08-31 00:00:00

abstract：:PerR, a member of Fur family of metal-dependent regulators, is a major peroxide sensor in many Gram positive bacteria, and controls the expression of genes involved in peroxide resistance. Bacillus licheniformis, a close relative to the well-studied model organism Bacillus subtilis, contains three PerR-like proteins (...

journal_title：Biochemical and biophysical research communications

authors： Kim JH,Won YB,Ji CJ,Yang YM,Ryu SH,Ju SY,Kwon Y,Lee YE,Lee JW

更新日期：2017-02-26 00:00:00

abstract：:Colorectal cancer is a common cancer with metachronous distant metastases still threatening overall survival. Tumor oxygen level influences tumor radiosensitivity in relation to autophagy and apoptosis. The objective of this study is to evaluate the expression and interaction between multiple key regulators in differe...

journal_title：Biochemical and biophysical research communications

authors： Tam SY,Wu VWC,Law HKW

更新日期：2019-09-17 00:00:00

abstract：:The primary amino acid sequence of the carboxyl-terminal portion of the alpha 3 chain of chicken type VI collagen (K-VI) presents a 58-residue motif with a high degree of homology with members of the Kunitz serine-proteinase inhibitors family. This module was cloned, expressed in E. coli, purified and compared to the ...

journal_title：Biochemical and biophysical research communications

authors： Bearz A,Tolazzi G,Leonardi A,Pucillo C,Tell G,Colombatti A,Formisano S

更新日期：1995-10-24 00:00:00

abstract：:The effect of tyrosine-phosphorylation on the conformation of three tyrosine-based immunoreceptor activation motifs, zeta(69-86), zeta(106-126), and zeta(138-155), located in the T cell receptor/CD3 zeta-chain was investigated. Circular dichroism and Fourier-transform infrared spectroscopy of the nonphosphorylated and...

journal_title：Biochemical and biophysical research communications

authors： Laczkó I,Hollósi M,Vass E,Hegedüs Z,Monostori E,Tóth GK

更新日期：1998-01-26 00:00:00

abstract：:Ligand-blotting and dot-blotting procedures were used to investigate the binding of [125I]-heparin to apolipoprotein E, its thrombin fragments E22 (residues 1-191) and E12 (residues 192-299), and to nine apolipoprotein E synthetic fragments. E22 and E12 bound [125I] heparin indicating multiple heparin-binding domains....

journal_title：Biochemical and biophysical research communications

authors： Cardin AD,Hirose N,Blankenship DT,Jackson RL,Harmony JA,Sparrow DA,Sparrow JT

更新日期：1986-01-29 00:00:00

abstract：:Ischemic stroke is a major cause of death and disability worldwide. Hyperneuroinflammation significantly contributes to ischemic stroke. Bromodomain-containing protein 4 (BRD4) is a member of the Bromo and Extra-Terminal (BET) family, and promotes inflammatory response in various types of tissue and cells. Thereby, we...

journal_title：Biochemical and biophysical research communications

authors： Zhou Y,Gu Y,Liu J

更新日期：2019-11-12 00:00:00

abstract：:Difluoromethylornithine (DFMO) depletes cells of polyamines, sensitizing cells against the action of antineoplastic drugs and altering ability to repair radiation-induced DNA strand breaks. Others have hypothesized that the mechanism by which polyamine depletion sensitizes cells is through inhibition of DNA strand bre...

journal_title：Biochemical and biophysical research communications

authors： Williams JR,Casero RA,Dillehay LE

更新日期：1994-05-30 00:00:00

abstract：:Tissue nicotinamide adenine dinucleotide (NAD+) decline has been implicated in aging. We have recently identified CD38 as a central regulator involved in tissue NAD+ decline during the aging process. CD38 is an ecto-enzyme highly expressed in endothelial and inflammatory cells. To date, the mechanisms that regulate CD...

journal_title：Biochemical and biophysical research communications

authors： Chini C,Hogan KA,Warner GM,Tarragó MG,Peclat TR,Tchkonia T,Kirkland JL,Chini E

更新日期：2019-05-28 00:00:00

abstract：:Based on a homology search with endostatin, the C-terminus 185 aa of collagen XVIII, we report the cloning, expression, and antiangiogenic activity of a 22 kDa human collagen XV fragment, that we have named restin. Restin was expressed in the prokaryotic pET expression system. We have shown that restin inhibits the mi...

journal_title：Biochemical and biophysical research communications

authors： Ramchandran R,Dhanabal M,Volk R,Waterman MJ,Segal M,Lu H,Knebelmann B,Sukhatme VP

更新日期：1999-02-24 00:00:00

abstract：:4-Hydroxyphenylacetic acid 3-hydroxylase is a key enzyme in the pathway for the microbial degradation of phenylalanine, tyrosine and many aromatic amines. This enzyme was purified to homogeneity from Pseudomonas putida by affinity chromatography. The protein had a molecular weight of 91,000 and was a dimer of identica...

journal_title：Biochemical and biophysical research communications

authors： Raju SG,Kamath AV,Vaidyanathan CS

更新日期：1988-07-29 00:00:00

abstract：:Rheumatoid arthritis (RA) is an autoimmune inflammatory disease exhibited most commonly in joints. We found that the expression of C1qtnf3, which encodes C1q/TNF-related protein 3 (CTRP3), was highly increased in two mouse RA models with different etiology. To elucidate the pathogenic roles of CTRP3 in the development...

journal_title：Biochemical and biophysical research communications

authors： Murayama MA,Kakuta S,Maruhashi T,Shimizu K,Seno A,Kubo S,Sato N,Saijo S,Hattori M,Iwakura Y

更新日期：2014-01-03 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have generated a great deal of interest in clinical situations, due principally to their potential use in regenerative medicine and tissue engineering applications. However, the therapeutic application of MSCs remains limited, unless the favorable effects of MSCs on tumor growth in vivo, ...

journal_title：Biochemical and biophysical research communications

authors： Shin KK,Lee AL,Kim JY,Lee SY,Bae YC,Jung JS

更新日期：2012-06-15 00:00:00

abstract：:The mechanism(s) by which HIV-1 infection contributes to depletion of CD4(+) T cell is not well understood. In this report, we investigated whether a recently identified isoform of growth factor receptor bound protein (Grb2), named Grb3-3, a signaling molecule that is associated with the MAP kinase pathway and with ap...

journal_title：Biochemical and biophysical research communications

authors： Li X,Multon MC,Henin Y,Schweighoffer F,Venot C,LaVecchio J,Josef J,Stuckert P,Mhashilkar A,Tocqué B,Marasco WA

更新日期：2000-09-16 00:00:00

abstract：:The Rv2477c protein of Mycobacterium tuberculosis (Mtb) belongs to the ATP-binding cassette (ABC) subfamily F that contains proteins with tandem nucleotide-binding domains but lacking transmembrane domains. ABC-F subfamily proteins have been implicated in diverse cellular processes such as translation, antibiotic resi...

journal_title：Biochemical and biophysical research communications

authors： Daniel J,Abraham L,Martin A,Pablo X,Reyes S

更新日期：2018-01-01 00:00:00

abstract：:Ku70 is a protein that finds itself at the heart of several important cellular processes. It is essential to the non-homologous end joining pathway as a part of the DNA-end binding complex, required for proper maintenance of telomeres and contributes to DNA damage recognition and regulation of apoptosis. Forces that r...

journal_title：Biochemical and biophysical research communications

authors： Yurchenko V,Xue Z,Gama V,Matsuyama S,Sadofsky MJ

更新日期：2008-02-01 00:00:00

abstract：:Signaling by TNF-family receptor CD40 involves TRAF-family adaptor proteins, leading to activation of protein kinases that induce NFkappaB-family transcription factors. We report here that mitogen activated protein kinase kinase kinase-8 (MAP3K8), Tpl2/COT1, is recruited to the CD40 complex via a mechanism dependent o...

journal_title：Biochemical and biophysical research communications

authors： Chan H,Reed JC

更新日期：2005-03-04 00:00:00