Upregulation of the apoptosis-associated protein Grb3-3 in HIV-1-infected human CD4(+) lymphocytes.

abstract：:The polyamines spermidine, spermine and putrescine, by themselves, at physiological concentrations, induce the transport of the precursor of ornithine carbamoyltransferase into isolated rat liver mitochondria. The presence of polyamines in the transport medium results in the approach of both mitochondrial membranes, s...

journal_title：Biochemical and biophysical research communications

authors： Marcote MJ,González-Bosch C,Miralles VJ,Hernández-Yago J,Grisolía S

更新日期：1989-01-16 00:00:00

abstract：:Keap1 is proposed to be a sensor protein of electrophilic compounds and a transducer of the signal from electrophilic compounds for transcriptional activation. Thus, the use of keap1 gene-knockout (KO) mice is a straightforward approach in order to clarify the molecular background for the use of electrophilies as neur...

journal_title：Biochemical and biophysical research communications

authors： Satoh T,Harada N,Hosoya T,Tohyama K,Yamamoto M,Itoh K

更新日期：2009-03-06 00:00:00

abstract：:Interest in lipoamino acids as endogenous modulators of G-protein coupled receptors has escalated due to their involvement in a variety of physiologic processes. In particular, a role for these amino acid conjugates has emerged in the endocannabinoid system. The study presented herein investigated the effects of N-ara...

journal_title：Biochemical and biophysical research communications

authors： Console-Bram L,Ciuciu SM,Zhao P,Zipkin RE,Brailoiu E,Abood ME

更新日期：2017-09-02 00:00:00

abstract：:Hepatitis C virus (HCV), a hepacivirus member of the Flaviviridae family, has a positive-stranded RNA genome, which consists of a single open reading frame (ORF) and nontranslated regions (NTRs) at the 5' and 3' ends. The 5'NTR was found to contain an internal ribosomal entry site (IRES), which is required for the tra...

journal_title：Biochemical and biophysical research communications

authors： Kim YK,Kim CS,Lee SH,Jang SK

更新日期：2002-01-11 00:00:00

abstract：:The availability of a human lymphoma cell line deficient in adenosine deaminase, adenosine kinase and methylthioadenosine phosphorylase enabled us to compare the effects of nucleoside transport inhibitors on the excretion of endogenously generated adenosine, deoxyadenosine and 5'-methylthioadenosine. The nucleoside tr...

journal_title：Biochemical and biophysical research communications

authors： Iizasa T,Kubota M,Carson DA

更新日期：1984-06-15 00:00:00

abstract：:The interaction of calcyclin with tropomyosin and tropomyosin-actin was studied with fluorescence titrations and photo-reactive crosslinking experiments. Titrations of pyreneiodoacetamide-labeled tropomyosin alone or with actin showed binding of calcyclin to tropomyosin with muM dissociation constants when Ca2+ was pr...

journal_title：Biochemical and biophysical research communications

authors： Golitsina NL,Kordowska J,Wang CL,Lehrer SS

更新日期：1996-03-18 00:00:00

abstract：:We developed a typing assay for HIV-1 using subtype specific peptides corresponding to the five major subtypes of HIV-1 (A to E). In eight patients serologically subtyped as A (n = 1), B (n = 3), C (n = 3) and E (n = 1) phyllogenetic analysis of sequenced V3 domain DNA completely correlated to the peptide serotyping. ...

journal_title：Biochemical and biophysical research communications

authors： Sherefa K,Sönnerborg A,Steinbergs J,Sällberg M

更新日期：1994-12-30 00:00:00

abstract：:Tat-interactive protein, 60kDa (Tip60) is a histone acetyltransferase with specificity toward lysine 5 of histone H2A (H2AK5) and plays multiple roles in chromatin remodeling processes. Co-immunoprecipitation experiments performed on Jurkat cells, showed that Tip60 is present in the same macro-molecular complex as UHR...

journal_title：Biochemical and biophysical research communications

authors： Achour M,Fuhrmann G,Alhosin M,Rondé P,Chataigneau T,Mousli M,Schini-Kerth VB,Bronner C

更新日期：2009-12-18 00:00:00

abstract：:Tyrosine-specific phosphorylated proteins found exclusively on the cell surface of human astrocytomas were previously identified with murine monoclonal antibodies, designated as GA-17, GB-4 and GC-3. The purpose of this study was to further characterize the antigens and investigate the relationship between them and c-...

journal_title：Biochemical and biophysical research communications

authors： Kondo S,Miyatake S,Matsumoto M,Nakatsu S,Iwasaki K,Oda Y,Kikuchi H,Namba Y

更新日期：1992-01-31 00:00:00

abstract：:Autophagy is an evolutionary conserved intracellular process whereby cells break down long-lived proteins and organelles. Accumulating evidences suggest increasing physiological significance of autophagy in pathogenesis of infectious diseases. Anthrax lethal toxin (LT) exerts its influence on numerous cells and herein...

journal_title：Biochemical and biophysical research communications

authors： Tan YK,Kusuma CM,St John LJ,Vu HA,Alibek K,Wu A

更新日期：2009-02-06 00:00:00

abstract：:Recently it has been shown that vascular endothelial cells (EC) are completely devoid of apoptosis if cultivated under a steady laminar flow and that apoptosis is induced by turning off the flow. An autocrine loop of thrombospondin-1 (TSP-1) and the alpha(v)beta(3) integrin/integrin-associated protein (IAP) complex ha...

journal_title：Biochemical and biophysical research communications

authors： Freyberg MA,Kaiser D,Graf R,Buttenbender J,Friedl P

更新日期：2001-08-10 00:00:00

abstract：:Dexamethasone produced an increased activity of stearoyl-CoA desaturase through the enhancement of delta 9-terminal component activity, and a corresponding decrease of oleoyl-CoA desaturase activity via the reduced activity of delta 12-terminal component in Tetrahymena microsomes. However, the content of cytochrome b5...

journal_title：Biochemical and biophysical research communications

authors： Umeki S,Nozawa Y

更新日期：1984-02-29 00:00:00

abstract：:An organoid is a complex, multi-cell three-dimensional (3D) structure that contains tissue-specific cells. Epithelial stem cells, which are marked by leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5), have the potential for self-renewal and expansion as organoids. However, in the case of intestinal or...

journal_title：Biochemical and biophysical research communications

authors： Hahn S,Kim MS,Choi SY,Jeong S,Jee J,Kim HK,Jeong SY,Shin H,Kim HS,Park JS,Yoo J

更新日期：2019-01-08 00:00:00

abstract：:PQBP-1 was identified as a binding protein to the polyglutamine tract present in various transcription-related factors and causative genes for neurodegenerative disorders. This novel gene contains at least two functional domains, WW domain and carboxyl-terminal domain (CTD), strictly conserved beyond species. Although...

journal_title：Biochemical and biophysical research communications

authors： Waragai M,Junn E,Kajikawa M,Takeuchi S,Kanazawa I,Shibata M,Mouradian MM,Okazawa H

更新日期：2000-07-05 00:00:00

abstract：:Recent studies indicate that galactoside-binding proteins may bind the poly-N-acetyllactosamine sequences of laminin. We questioned whether human galactoside-binding protein (hL-31) binds to laminin and whether cells that express hL-31 on their surface use it as a laminin receptor to promote cellular attachment. The d...

journal_title：Biochemical and biophysical research communications

authors： Ochieng J,Gerold M,Raz A

更新日期：1992-08-14 00:00:00

abstract：:Clones of eukaryotic initiation factor (eIF) 4B from wheat and Arabidopsis thaliana were obtained from cDNA and genomic libraries. The exon/intron organization of the genes from wheat and A. thaliana is very similar. The deduced amino acid sequences for the wheat and Arabidopsis eIF4B proteins showed overall similarit...

journal_title：Biochemical and biophysical research communications

authors： Metz AM,Wong KC,Malmström SA,Browning KS

更新日期：1999-12-20 00:00:00

abstract：:Protein Z was purified from rabbit liver cytosol by affinity chromatography on oleic acid-agarose and preparative sodium dodecyl sulfate-polyacrylamide gel electrophoresis. After removal of sodium dodecyl sulfate, the renatured protein was found to bind heme and bilirubin with a Kd of approximately 1 microM which prod...

journal_title：Biochemical and biophysical research communications

authors： Vincent SH,Holeman B,Muller-Eberhard U

更新日期：1985-10-30 00:00:00

abstract：:Oxidation of low-density lipoproteins (LDLs) induces development of cardiovascular disease. Recently, reports of studies using atomic force microscopy (AFM) have described that the elastic modulus of metal-induced oxidized LDLs is lower than the modulus before oxidation. However, the mechanisms of change of the elasti...

journal_title：Biochemical and biophysical research communications

authors： Takeda S,Sakurai T,Hui SP,Fuda H,Chiba H

更新日期：2018-06-27 00:00:00

abstract：:We examined the effect of low density lipoprotein (LDL) on histamine release from purified human lung mast cells. LDL inhibited anti-IgE- induced histamine release in a dose-dependent manner, with 100 micrograms/ml LDL-protein inhibiting histamine release by 53 +/- 8% (mean +/- SEM); half-maximal inhibition occurred a...

journal_title：Biochemical and biophysical research communications

authors： Schulman ES,Quinn TJ,Post TJ,O'Donnell P,Rodriguez A,Gonen B

更新日期：1987-10-29 00:00:00

abstract：:In several inflammatory conditions such as rheumatoid arthritis or sepsis, the regulatory mechanisms of inflammation are inefficient and the excessive inflammatory response leads to damage to the host. Sirtuins are class III histone deacetylases that modulate the activity of several transcription factors that are impl...

journal_title：Biochemical and biophysical research communications

authors： Fernandes CA,Fievez L,Neyrinck AM,Delzenne NM,Bureau F,Vanbever R

更新日期：2012-04-20 00:00:00

abstract：:Neurofibromatosis type 1 is a common genetic disease that causes nervous system tumors, and cognitive deficits. It is due to mutations within the NF1 gene, which encodes the Nf1 protein. Nf1 has been shown to be involved in the regulation of Ras, cAMP and actin cytoskeleton dynamics. In this study, using immunofluores...

journal_title：Biochemical and biophysical research communications

authors： Godin F,Villette S,Vallée B,Doudeau M,Morisset-Lopez S,Ardourel M,Hevor T,Pichon C,Bénédetti H

更新日期：2012-02-24 00:00:00

abstract：:Previously we demonstrated that the histamine H2 receptor can activate both the adenylate cyclase and phosphoinositide/protein kinase (PKC) signaling pathways. Although dual coupling occurs via separate GTP-dependent mechanisms the structural components of the H2 receptor directing differential signaling have not been...

journal_title：Biochemical and biophysical research communications

authors： Wang LD,Gantz I,Butler K,Hoeltzel M,Del Valle J

更新日期：2000-09-24 00:00:00

abstract：:In order to study the role of phosphatidylinositol-3-kinase (PI3K) in insulin action, we employed a specific inhibitor of PI3K, LY294002, and measured five biological functions of insulin in mouse 3T3 fibroblasts overexpressing human insulin receptors. LY294002 had no effect on tyrosine phosphorylation of both the ins...

journal_title：Biochemical and biophysical research communications

authors： Sanchez-Margálet V,Goldfine ID,Vlahos CJ,Sung CK

更新日期：1994-10-28 00:00:00

abstract：:We have documented that the oncoprotein hepatitis B X-interacting protein (HBXIP) is able to promote migration of breast cancer cells. A subset of acetylated microtubules that accumulates in the cell leading edge is necessary for cell polarization and directional migration. In this study, we explored the hypothesis th...

journal_title：Biochemical and biophysical research communications

authors： Li L,Liu B,Zhang X,Ye L

更新日期：2015-03-13 00:00:00

abstract：:Here we analyzed Pfkfb3 and Pfkfb4 gene expression in rat testis development, isolated testicular cells and spermatozoa. Real time RT-PCR analysis during testis development showed the maximum expression of Pfkfb3 in pre-puber samples and of Pfkfb4 in adult samples. Western blot analysis showed that uPFK-2 protein, a p...

journal_title：Biochemical and biophysical research communications

authors： Gómez M,Navarro-Sabaté A,Manzano A,Duran J,Obach M,Bartrons R

更新日期：2009-09-18 00:00:00

abstract：:Information on the immune response against H5N1 within the lung is lacking. Here we describe the sustained antiviral immune responses, as indicated by the expression of MxA protein and IFN-alpha mRNA, in autopsy lung tissue from an H5N1-infected patient. H5N1 infection of primary bronchial/tracheal epithelial cells an...

journal_title：Biochemical and biophysical research communications

authors： Thitithanyanont A,Engering A,Uiprasertkul M,Ekchariyawat P,Wiboon-Ut S,Kraivong R,Limsalakpetch A,Kum-Arb U,Yongvanitchit K,Sa-Ard-Iam N,Rukyen P,Mahanonda R,Kawkitinarong K,Auewarakul P,Utaisincharoen P,Sirisinha S,Mason

更新日期：2010-08-06 00:00:00

abstract：:Insulin-like growth factor 1 receptor (IGF1R) is expressed in many types of solid tumors including non-small cell lung cancer (NSCLC), and enhanced activation of IGF1R is thought to reflect cancer progression. Epithelial-mesenchymal transition (EMT) has been established as one of the mechanisms responsible for cancer ...

journal_title：Biochemical and biophysical research communications

authors： Nurwidya F,Takahashi F,Kobayashi I,Murakami A,Kato M,Minakata K,Nara T,Hashimoto M,Yagishita S,Baskoro H,Hidayat M,Shimada N,Takahashi K

更新日期：2014-12-12 00:00:00

abstract：:Deficiency of Smad3, an intracellular mediator of TGF-β, was shown to significantly accelerate re-epithelialization of the colonic mucosa. This study was performed to investigate the molecular mechanisms by which Smad3 controls colonic epithelial cell proliferation and crypt formation. Smad3(ex8/ex8) C57BL/6 mice were...

journal_title：Biochemical and biophysical research communications

authors： Furukawa K,Sato T,Katsuno T,Nakagawa T,Noguchi Y,Tokumasa A,Yokote K,Yokosuka O,Saito Y

更新日期：2011-02-25 00:00:00

abstract：:Hepatocyte growth factor (HGF) specifically activates Met tyrosine kinase receptor, leading to mitogenic, motogenic, and morphogenic responses in a wide variety of cells. To know a role of HGF in Xenopus embryogenesis, loss-of-function mutation was introduced by dominant expression of truncated tyrosine kinase-negativ...

journal_title：Biochemical and biophysical research communications

authors： Aoki S,Takahashi K,Matsumoto K,Nakamura T

更新日期：1997-05-08 00:00:00

abstract：:Parathyroid hormone (PTH) significantly affects osteoblast function by altering gene expression. We have identified neuron-derived orphan receptor-1 (NOR-1) as a PTH-induced primary gene in osteoblastic cells. NOR-1, Nurr1, and Nur77 comprise the NGFI-B nuclear orphan receptor family and Nurr1 and Nur77 are PTH-induce...

journal_title：Biochemical and biophysical research communications

authors： Pirih FQ,Nervina JM,Pham L,Aghaloo T,Tetradis S

更新日期：2003-06-20 00:00:00