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Modulation by dexamethasone of the fatty acyl-CoA desaturase system in Tetrahymena microsomes.

Abstract：

:Dexamethasone produced an increased activity of stearoyl-CoA desaturase through the enhancement of delta 9-terminal component activity, and a corresponding decrease of oleoyl-CoA desaturase activity via the reduced activity of delta 12-terminal component in Tetrahymena microsomes. However, the content of cytochrome b5 as well as the activities of NAD(P)H-cytochrome c and NADH-ferricyanide reductases showed no significant changes by dexamethasone. Additionally, dexamethasone evoked a 3.5-fold increase of intracellular cyclic AMP content 2 hr after administration. These results suggest that dexamethasone may modulate microsomal fatty acyl-CoA desaturase system in Tetrahymena by increasing intracellular cyclic AMP content.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Umeki S,Nozawa Y

doi

10.1016/0006-291x(84)91666-8

subject

Has Abstract

pub_date

1984-02-29 00:00:00

pages

401-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(84)91666-8

journal_volume

119

pub_type

杂志文章

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