Formation of HIV-1 envelope-hepatitis B core antigen hybrids with high affinity for CD4.

abstract：:Addition of NH4+ to STreptomyces griseus 2682 cells grown in NO3- containing medium resulted in a rapid decline in glutamine synthetase activity due to covalent modification of the enzyme. The NH4+ promoted inactivation of the enzyme was inhibited by the ADP-ribosyltransferase inhibitor 3-methoxybenzamide. In the pres...

journal_title：Biochemical and biophysical research communications

authors： Penyige A,Kálmánczhelyi A,Sipos A,Ensign JC,Barabás G

更新日期：1994-10-28 00:00:00

abstract：:In fresh water planarian Dugesia japonica, two genes encoding POU-domain proteins, DjPOU1 and DjPOU2, have been identified by polymerase chain reaction (PCR). Their POU-domains are strikingly similar to class III POU-domains in mammals, frog, insects and nematode. The full-length cDNA of DjPOU1 has been cloned and seq...

journal_title：Biochemical and biophysical research communications

authors： Orii H,Agata K,Watanabe K

更新日期：1993-05-14 00:00:00

abstract：:Sleep deprivation (SD) has detrimental effects on the physiological function of the brain. However, the underlying mechanism remains elusive. In the present study, we investigated the expression of candidate plasticity-related gene 15 (cpg15), a neurotrophic gene, and its potential role in SD using a REM-SD mouse mode...

journal_title：Biochemical and biophysical research communications

authors： Li CJ,Li JJ,Jiang Y,Mu YW,Lu DX,Xiao ZY,Jiang HY,Zhao JJ,Chen XH

更新日期：2020-02-12 00:00:00

abstract：:Studies suggest that the anticancer drugs VP16-213 and VM26 produce cytotoxicity by inducing protein-associated DNA breakage in vivo through interaction with a yet unknown nuclear component. The effects of these drugs and their congeners on topoisomerase activities was investigated. VP16-213, VM26, and congeners activ...

journal_title：Biochemical and biophysical research communications

authors： Minocha A,Long BH

更新日期：1984-07-18 00:00:00

abstract：:Prolactin enhanced guanylate cyclase [E.C.4.6.1.2] two- to threefold in ovary, testis, mammary gland, liver and kidney. Dose response relationships revealed that maximal activation of this enzyme was at a concentration of one nanomolar and that increasing prolactin's concentration to the millimolar range caused no fur...

journal_title：Biochemical and biophysical research communications

authors： Vesely DL

更新日期：1984-09-28 00:00:00

abstract：:Human embryonic stem cells (hESCs) are thought to be a promising cell source for cell transplantation therapy. For such a clinical application, the hESCs should be manipulated using appropriate and qualified materials. In this study, we examined the efficacy of recombinant human laminin (rhLM) isoforms on the undiffer...

journal_title：Biochemical and biophysical research communications

authors： Miyazaki T,Futaki S,Hasegawa K,Kawasaki M,Sanzen N,Hayashi M,Kawase E,Sekiguchi K,Nakatsuji N,Suemori H

更新日期：2008-10-10 00:00:00

abstract：:Cell growth and differentiation are opposite events in the myogenic lineage. Growth factors block the muscle differentiation program by inducing the expression of transcription factors that negatively regulate the expression of muscle regulatory genes like MyoD. In contrast, extracellular clues that induce cell cycle ...

journal_title：Biochemical and biophysical research communications

authors： Pedraza-Alva G,Zingg JM,Donda A,Pérez-Martínez L

更新日期：2009-11-13 00:00:00

abstract：:A single nucleotide polymorphism (SNP) resulting in a substitution from Gln to His was found in exon 4 of the CYP2B6 gene in Japanese. The frequency of the variant allele was found to be 19.9%. The mutant- and the wild-type enzymes were expressed in Escherichia coli, and the effects of the single amino acid substituti...

journal_title：Biochemical and biophysical research communications

authors： Ariyoshi N,Miyazaki M,Toide K,Sawamura Yi,Kamataki T

更新日期：2001-03-01 00:00:00

abstract：:Mouse peritoneal macrophages metabolize dihomogammalinolenic acid (20:3n-6) primarily to 15-hydroxy-8,11,13-eicosatrienoic acid (15-OH-20:3). Since the biological properties of this novel trienoic eicosanoid remain poorly defined, the effects of increasing concentrations of 15-OH-20:3 and its arachidonic acid (20:4n-6...

journal_title：Biochemical and biophysical research communications

authors： Chapkin RS,Miller CC,Somers SD,Erickson KL

更新日期：1988-06-16 00:00:00

abstract：:The hyaluronan receptor for endocytosis (HARE), or Stabilin-2, is the mammalian endocytic clearance receptor for HA, heparin, advanced glycation end-products, acetylated and oxidized low-density lipoproteins and collagen N-terminal propeptides. This large 2551 amino acid receptor is encoded by a gene that covers over ...

journal_title：Biochemical and biophysical research communications

authors： Hare AK,Harris EN

更新日期：2015-01-02 00:00:00

abstract：:Stromal cell-derived factor 1 (SDF-1) regulates neovascularization, which is coordinately controlled by endothelial cells (EC) and their surrounding cells, pericytes or smooth muscle cells. In the basal state, SDF-1 expression is much lower in EC than in their surrounding cells. In this study, we evaluated epigenetic ...

journal_title：Biochemical and biophysical research communications

authors： Seo J,Kim YO,Jo I

更新日期：2009-05-08 00:00:00

abstract：:Upon centrifugation of gently lysed T. cruzi cells through a sucrose gradient, a free DNA fraction was shown to contain catenated dimers and knotted DNA structures. Southern hybridization and electron microscopic studies indicated that both of these structures derived from minicircle DNA, the major component of T. cru...

journal_title：Biochemical and biophysical research communications

authors： Valenzuela MS,Bardhan S,Krishnamani MR,Siddiqui KA

更新日期：1991-01-31 00:00:00

abstract：:Nucleoside diphosphate (NDP) kinase is an enzyme that transfers the gamma-phosphate of nucleoside triphosphates to nucleoside diphosphates. Besides this well-defined role, recent evidence suggests that NDP kinase may be implicated in a wide variety of essential cellular processes. In this paper, we showed that the NDP...

journal_title：Biochemical and biophysical research communications

authors： Inoue H,Takahashi M,Oomori A,Sekiguchi M,Yoshioka T

更新日期：1996-01-26 00:00:00

abstract：:Clones of eukaryotic initiation factor (eIF) 4B from wheat and Arabidopsis thaliana were obtained from cDNA and genomic libraries. The exon/intron organization of the genes from wheat and A. thaliana is very similar. The deduced amino acid sequences for the wheat and Arabidopsis eIF4B proteins showed overall similarit...

journal_title：Biochemical and biophysical research communications

authors： Metz AM,Wong KC,Malmström SA,Browning KS

更新日期：1999-12-20 00:00:00

abstract：:The late endosomal marker Rab7 has been long believed to be absent from the phagosome containing Mycobacterium tuberculosis (M.tb) in macrophage, but the detail kinetics remains elusive. Here, we found that Rab7 is transiently recruited to and subsequently released from M.tb phagosomes. For further understanding of th...

journal_title：Biochemical and biophysical research communications

authors： Seto S,Matsumoto S,Ohta I,Tsujimura K,Koide Y

更新日期：2009-09-18 00:00:00

abstract：:During rat liver regeneration, at the onset of S-phase of the first cell cycle, an enhanced mevalonate incorporation into prenylated proteins is observed. The analysis of the lipid moieties of such proteins shows a 20-fold increased content of geraniol and farnesol. The expected increase of farnesylated and geranylger...

journal_title：Biochemical and biophysical research communications

authors： Bruscalupi G,Castellano F,Sacco S,Trentalance A

更新日期：1994-05-16 00:00:00

abstract：:Tetrodotoxin-binding sites were covalently labelled with a highly tritiated derivative of tetrodotoxin. Cross-linking experiments, using dissucinimidyl suberate, on partially purified tetrodotoxin-binding component from electroplax of Electrophorus electricus, revealed covalent labelling of a single polypeptide chain ...

journal_title：Biochemical and biophysical research communications

authors： Lombet A,Norman RI,Lazdunski M

更新日期：1983-07-18 00:00:00

abstract：:GPR35, previously an orphan G-protein coupled receptor, is a receptor for kynurenic acid. Here we examine the distribution of GPR35 in the rat dorsal root ganglion (DRG) and the effects of its selective activation. GPR35 was expressed predominantly by small- to medium-diameter neurons of the DRG. Many of these same ne...

journal_title：Biochemical and biophysical research communications

authors： Ohshiro H,Tonai-Kachi H,Ichikawa K

更新日期：2008-01-11 00:00:00

abstract：:A monoclonal antibody (MaB) against mouse sarcoma DNA polymerase alpha was isolated from the culture medium of an IgG-secreting hybridoma. The MaB demonstrated reactivity against two murine DNA polymerase alpha preparations and a calf thymus DNA polymerase alpha. Murine sarcoma polymerase was activated in vitro by pho...

journal_title：Biochemical and biophysical research communications

authors： Sylvia VL,Norman JO,Curtin GM,Busbee DL

更新日期：1986-11-26 00:00:00

abstract：:The metabolic pathway such as glyoxylate cycle (GC) enables Candida albicans, to survive under glucose deficient conditions prevalent in the hostile niche. Thus its key enzymes (Isocitrate lyase; ICL and malate synthase; MLS) represent attractive targets against C. albicans. We have previously reported the antifungal ...

journal_title：Biochemical and biophysical research communications

authors： Ansari MA,Fatima Z,Ahmad K,Hameed S

更新日期：2018-01-01 00:00:00

abstract：:Interactions between C1q and other subunits of C1 were analyzed by sucrose gradient ultracentrifugation. A zone of dilute, radioiodine labelled C1q was sedimented through uniform concentrations of either C1r2C1s2, C1r2, C1r2 or C1s(2). The dissociation constants were found to be 3 x 10(-9) M and 6 x 10(-9) M for C1r2C...

journal_title：Biochemical and biophysical research communications

authors： Lakatos S

更新日期：1987-12-16 00:00:00

abstract：:Stefin B is the major general cytosolic protein inhibitor of cysteine cathepsins. Its main function is to protect the organism against the activity of endogenous potentially hazardous proteases accidentally released from lysosomes. In this study, we investigated the possible effect of endosomal/lysosomal aspartic cath...

journal_title：Biochemical and biophysical research communications

authors： Železnik TZ,Kadin A,Turk V,Dolenc I

更新日期：2015-09-18 00:00:00

abstract：:p8 is an 80 amino-acid polypeptide identified because of its remarkable over-expression in the stressed pancreas. This protein, apparently devoid of enzymatic activity, is a powerful regulator of several intracellular pathways, suggesting that it has to interact with several molecular partners to modulate their activi...

journal_title：Biochemical and biophysical research communications

authors： Malicet C,Hoffmeister A,Moreno S,Closa D,Dagorn JC,Vasseur S,Iovanna JL

更新日期：2006-01-06 00:00:00

abstract：:OPA1 is a cause gene for autosomal dominant optic atrophy and possesses eight alternative splicing variants. Here, we identified two isoforms of OPA1 proteins in HeLa cells and examined their submitochondrial localization and complex formations. RT-PCR shows that HeLa cells mainly express isoforms 7 and 1 of OPA1. Sin...

journal_title：Biochemical and biophysical research communications

authors： Satoh M,Hamamoto T,Seo N,Kagawa Y,Endo H

更新日期：2003-01-10 00:00:00

abstract：:The main function of Erythropoietin (EPO) and its receptor (EPOR) is the stimulation of erythropoiesis. Recombinant human EPO (rhEPO) is therefore used to treat anemia in cancer patients. However, clinical trials have indicated that rhEPO treatment might promote tumor progression and has a negative effect on patient s...

journal_title：Biochemical and biophysical research communications

authors： Reinbothe S,Larsson AM,Vaapil M,Wigerup C,Sun J,Jögi A,Neumann D,Rönnstrand L,Påhlman S

更新日期：2014-02-28 00:00:00

abstract：:There is a close linear correlation between the log partition coefficient (Pa) of a series of 2'-deoxyriboside (dR), 2',3'-didehydro-3'-dideoxyriboside (ddeR), 2',3'-dideoxyriboside (ddR), 3'-fluoro-2',3'-dideoxyriboside (FddR) and 3'-azido-2',3'-dideoxyriboside (AzddR) derivatives of uracil, cytosine, thymine, guanin...

journal_title：Biochemical and biophysical research communications

authors： Balzarini J,Cools M,De Clercq E

更新日期：1989-01-31 00:00:00

abstract：:Previous investigations in our laboratory demonstrated the existence of an intrinsic mechanism, termed membrane modulation, capable of restoring sensitivity to aspirin treated platelets, resulting in irreversible aggregation in response to arachidonic acid (AA). The mechanism underlying correction of aspirin induced i...

journal_title：Biochemical and biophysical research communications

authors： Rao GH,Radha E,White JG

更新日期：1985-08-30 00:00:00

abstract：:Vibrio vulnificus, a halophilic estuarine bacterium causing a rapidly progressing fatal septicemia, is highly cytotoxic to eukaryotic cells. To identify new virulence factors associated with cytotoxicity, we constructed a mariner-based transposon (Tn Himar1) library of the highly virulent clinical isolate MO6-24/O hav...

journal_title：Biochemical and biophysical research communications

authors： Ran Kim Y,Haeng Rhee J

更新日期：2003-05-02 00:00:00

abstract：:In this report, we describe the expression and function of human Sp5, a member of the Sp family of zinc finger transcription factors. Like other family members, the Sp5 protein contains a Cys2His2 zinc finger DNA binding domain at the C-terminus. Our experiments employing Gal4-Sp5 fusion proteins reveal multiple trans...

journal_title：Biochemical and biophysical research communications

authors： Chen Y,Guo Y,Ge X,Itoh H,Watanabe A,Fujiwara T,Kodama T,Aburatani H

更新日期：2006-02-17 00:00:00

abstract：:Comprehensive knowledge on the murine CT26 colon carcinoma line is a classic model used in the pharmacodynamic experiments involving IDO-1 inhibitors, immune-related checkpoint antibodies and immune related mechanisms. In this study, we determined the impact of different subcutaneous inoculation locations on tumor gro...

journal_title：Biochemical and biophysical research communications

authors： Fu X,Yang Y,Xie J,Pan X,Yang X,Du Z,Hao E

更新日期：2019-04-30 00:00:00