Prenylated proteins in regenerating rat liver.

abstract：:The aim of this study was to investigate the response to and the physiological consequences of copper-mediated cross-linking of S100A2 and S100A4, two members of the S100 family of EF-hand calcium-binding proteins. As demonstrated by electrophoresis and mass spectrometry techniques S100A2 and S100A4 show formation of ...

journal_title：Biochemical and biophysical research communications

authors： Haase-Kohn C,Wolf S,Lenk J,Pietzsch J

更新日期：2011-09-30 00:00:00

abstract：:A truncated form of 24kDa FGF-2 consisting of 86 NH(2)-terminal amino acids (ATE+31) inhibits cell migration in vitro and tumor development and angiogenesis in vivo. Focal adhesion kinase (FAK) is phosphorylated on tyrosine and serine sites after cell stimulation by growth factors. This study examined the effect of AT...

journal_title：Biochemical and biophysical research communications

authors： Lin AH,Eliceiri BP,Levin EG

更新日期：2009-05-08 00:00:00

abstract：:Rheumatoid arthritis (RA) is one of the most common autoimmune diseases, but its autoimmune mechanisms are not clearly understood. Recently, anti-citrullinated peptide antibodies have been specifically observed in sera of RA patients. Furthermore, we identified RA-susceptible variant in a gene encoding citrullinating ...

journal_title：Biochemical and biophysical research communications

authors： Suzuki A,Yamada R,Ohtake-Yamanaka M,Okazaki Y,Sawada T,Yamamoto K

更新日期：2005-07-29 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is a gamma-herpesvirus that is frequently associated with the formation of tumors like Kaposi's sarcoma and primary effusion lymphomas. KSHV RTA is required for lytic replication/reactivation in KSHV-infected cells. We developed an inducible RTA expression cell line to se...

journal_title：Biochemical and biophysical research communications

authors： Yada K,Do E,Sakakibara S,Ohsaki E,Ito E,Watanabe S,Ueda K

更新日期：2006-06-23 00:00:00

abstract：:By radiolabeling using NaIO4/[3H]KBH4, a new sialoglycoprotein with Mr of 19,000 was found in the secretion of rat seminal vesicle. It was shown to interact non-covalently with semen coagulum. It existed in three acidic forms with pI values of 4.1, 3.7 and 2.9 and possessed high contents of sialic acids and acidic ami...

journal_title：Biochemical and biophysical research communications

authors： Limpaseni T,Chulavatnatol M

更新日期：1986-04-29 00:00:00

abstract：:Ubiquitin-conjugating enzyme E2S (UBE2S) plays pivotal roles in the progression of human cancers. However, its clinical significance and role in hepatocellular carcinoma (HCC) remain unknown. Here, we show that UBE2S is upregulated in HCC and exhibits oncogenic activities via enhancing the ubiquitination of p53. Incre...

journal_title：Biochemical and biophysical research communications

authors： Pan YH,Yang M,Liu LP,Wu DC,Li MY,Su SG

更新日期：2018-09-05 00:00:00

abstract：:Phenylenediamine derivatives can function as a hydrogen donor and reportedly exert various biological actions including cytoprotective effects against oxidative stress, possibly by acting as an antioxidant. Previous studies showed that feeding of such compounds to mice reduced their body weight, but the precise mechan...

journal_title：Biochemical and biophysical research communications

authors： Yanagitai M,Kitagawa T,Okawa K,Koyama H,Satoh T

更新日期：2012-01-06 00:00:00

abstract：:Membrane-type 1 matrix metalloproteinase (MT1-MMP) localized on the plasma membrane plays a central role in various normal biological responses including tissue remodeling, wound heeling, and angiogenesis and in cancer cell invasion and metastasis, by functioning as a collagenase and activating other matrix metallopro...

journal_title：Biochemical and biophysical research communications

authors： Miyata T,Ohnishi H,Suzuki J,Yoshikumi Y,Ohno H,Mashima H,Yasuda H,Ishijima T,Osawa H,Satoh K,Sunada K,Kita H,Yamamoto H,Sugano K

更新日期：2004-10-08 00:00:00

abstract：:The effects of isolated platelet surface membranes on DNA synthesis and proliferation of bovine coronary artery smooth muscle cells (SMC) were studied. Platelet membranes were very potent mitogens for SMC. The potency was about 10-fold higher than the maximum effects of platelet-derived growth factor-BB (PDGF). Platel...

journal_title：Biochemical and biophysical research communications

authors： Weber AA,Zucker TP,Schrör K

更新日期：1999-06-07 00:00:00

abstract：:We have purified and characterized recombinant Xenopus bone morphogenetic proteins (xBMPs): homodimers of xBMP-4, 7 and heterodimers (xBMP-4/7) produced by a baculovirus expression system. Highly purified xBMPs had homogeneous NH2-termini predicted from a consensus motif, Arg-X-X-Arg, while they possessed diverse suga...

journal_title：Biochemical and biophysical research communications

authors： Aono A,Hazama M,Notoya K,Taketomi S,Yamasaki H,Tsukuda R,Sasaki S,Fujisawa Y

更新日期：1995-05-25 00:00:00

abstract：:Excessive oxidative stress induces significant injury and cytotoxicity to neuronal cells. The current study tested expression and the potential function of the circular RNA PRKCI (circPRKCI) in oxidative stress-injured neuronal cells. In cultured SH-SY5Y neuronal cells, hydrogen peroxide (H2O2) downregulated circPRKCI...

journal_title：Biochemical and biophysical research communications

authors： Cheng Q,Cao X,Xue L,Xia L,Xu Y

更新日期：2019-06-25 00:00:00

abstract：:Glutathione S-transferase P (GST-P) exists as a homodimeric form and has two tryptophan residues, Trp28 and Trp38, in each subunit. In order to elucidate the role of the two tryptophan residues in catalytic function, we examined intrinsic fluorescence of tryptophan residues and effect of chemical modification by N-bro...

journal_title：Biochemical and biophysical research communications

authors： Nishihira J,Ishibashi T,Sakai M,Nishi S,Kumazaki T

更新日期：1992-06-30 00:00:00

abstract：:The physical and catalytic properties of 5 histidine-serine mutants of human 5-lipoxygenase (5-LO) have been characterized. The mutants HS363, HS391 and HS400 have activities, pH optima and stabilities similar to those of the wild type enzyme. The iron content of each of these mutants is 0.30-0.53 mol Fe/mol 5-LO whic...

journal_title：Biochemical and biophysical research communications

authors： Percival MD,Ouellet M

更新日期：1992-08-14 00:00:00

abstract：:In eukaryotes, the poly(A)-binding protein (PABP) is one of the important factors for initiation of messenger RNA translation. PABP activity is regulated by the PABP-interacting proteins (Paips), which include Paip1, Paip2A, and Paip2B. Human Paip1 has three different isoforms. Here, we report the crystal structure of...

journal_title：Biochemical and biophysical research communications

authors： Lei J,Mesters JR,von Brunn A,Hilgenfeld R

更新日期：2011-05-20 00:00:00

abstract：:The c-Jun N-terminal Kinases (JNKs) play important roles in cell responses to stress or growth factor stimulation. The JNK1α1 isoform shares >90% identity with a predominantly neuronal JNK3α1 isoform, but JNK3α1 also includes a distinctive 38 amino acid N-terminal sequence. To address the outstanding question of the p...

journal_title：Biochemical and biophysical research communications

authors： Chen WK,Yeap YY,Bogoyevitch MA

更新日期：2014-10-24 00:00:00

abstract：:Peroxisomes catalyze a number of essential metabolic functions especially related to lipid metabolism. There is increasing evidence suggesting that peroxisomes are also involved in the synthesis of isoprenoids via the mevalonate pathway at least in rat liver. In order to obtain independent evidence for a role of perox...

journal_title：Biochemical and biophysical research communications

authors： Wanders RJ,Romeijn GJ

更新日期：1998-06-29 00:00:00

abstract：:Autophagy is an apoptosis-independent mechanism of cell death that protects the cell from environmental imbalances and infection by pathogens. We identified a novel small molecule, 2-(3-Benzyl-4-oxo-3,4,5,6,7,8-hexahydro-benzo[4,5]thieno[2,3-d]pyrimidin-2-ylsulfanylmethyl)-oxazole-4-carboxylic acid (2-pyrrolidin-1-yl-...

journal_title：Biochemical and biophysical research communications

authors： Choi IK,Cho YS,Jung HJ,Kwon HJ

更新日期：2010-03-19 00:00:00

abstract：:CD133-expressing glioma cells play a critical role in tumor recovery after treatment and are resistant to radiotherapy. Herein, we demonstrated that glioblastoma-derived CD133-positive cells (GBM-CD133(+)) are capable of self-renewal and express high levels of embryonic stem cell genes and SirT1 compared to GBM-CD133(...

journal_title：Biochemical and biophysical research communications

authors： Chang CJ,Hsu CC,Yung MC,Chen KY,Tzao C,Wu WF,Chou HY,Lee YY,Lu KH,Chiou SH,Ma HI

更新日期：2009-03-06 00:00:00

abstract：:We have previously shown that the neurosteroid pregnenolone sulfate (PS) inhibits the capsaicin receptor-mediated current in rat dorsal root ganglion neurons. Here, we examined the effect of intradermal injection of PS into the rat hindpaw on capsaicin-induced nociception. Results revealed that PS co-injected with cap...

journal_title：Biochemical and biophysical research communications

authors： Chen SC,Liu BC,Chen CW,Wu FS

更新日期：2006-10-20 00:00:00

abstract：:Incubation of purified bovine photoreceptor rod outer segments with [gamma-32P]ATP resulted in the labeling of phosphatidylinositol 4-phosphate (PIP) and phosphatidic acid (PA) with little labeling of phosphatidylinositol 4,5-bisphosphate (PIP2). Propranolol inhibited in a dose-dependent manner the labeling of PA and ...

journal_title：Biochemical and biophysical research communications

authors： Van Rooijen LA,Bazan NG

更新日期：1986-01-14 00:00:00

abstract：:The mechanism by which lithium (Li(+)) inhibits the protein kinase glycogen synthase kinase-3 (GSK-3) is unknown. Here, we demonstrate that Li(+) is a competitive inhibitor of GSK-3 with respect to magnesium (Mg(2+)), but not to substrate or ATP. This mode of inhibition is conserved between mammalian and Dictyostelium...

journal_title：Biochemical and biophysical research communications

authors： Ryves WJ,Harwood AJ

更新日期：2001-01-26 00:00:00

abstract：:Several rat liver cytochromes P-450 have been substantially purified in a one-step immunoadsorption procedure using Sepharose-bound monoclonal antibodies (MAbs) to the major forms of rat liver cytochrome P-450 induced by 3-methylcholanthrene and phenobarbital (MC-P-450 and PB-P-450, respectively). When mixed with solu...

journal_title：Biochemical and biophysical research communications

authors： Friedman FK,Robinson RC,Park SS,Gelboin HV

更新日期：1983-11-15 00:00:00

abstract：:Free D-aspartic acid is present in appreciable quantities in the brain and other tissues of rodents and in human blood. In the newborn rat, the highest concentration of D-aspartic acid was found in cerebral hemispheres, where, at 164 nmol/g (8.4% of the total aspartic acid), the level of D-aspartic acid exceeds that o...

journal_title：Biochemical and biophysical research communications

authors： Dunlop DS,Neidle A,McHale D,Dunlop DM,Lajtha A

更新日期：1986-11-26 00:00:00

abstract：:Human lymphocyte growth response to mitogen was examined in vitro under different conditions to monitor aspects of carbohydrate utilization in three groups: obese nondiabetic, obese/NIDDM, and normal-weight individuals. Although lymphocyte growth capacity in minimal medium for these three groups was found to be simila...

journal_title：Biochemical and biophysical research communications

authors： Tu KY,Matthews R,Topek NH,Matthews KS

更新日期：1994-07-29 00:00:00

abstract：:Some mutations in mitochondrial DNA (mtDNA) causing a number of neuromuscular diseases are suggested to arise spontaneously during the life of an individual. To substantiate the extent and the rate of these somatic mutations, mtDNA specimens from post-mortem human heart muscles of subjects in differing age groups were...

journal_title：Biochemical and biophysical research communications

authors： Hayakawa M,Hattori K,Sugiyama S,Ozawa T

更新日期：1992-12-15 00:00:00

abstract：:Ribosomal proteins must be imported into the nucleus after being synthesized in the cytoplasm. Since the rpS2 amino acid sequence does not contain a typical nuclear localization signal, we used deletion mutant analysis and rpS2-beta-galactosidase chimeric proteins to identify the nuclear targeting domains in rpS2. Nuc...

journal_title：Biochemical and biophysical research communications

authors： Antoine M,Reimers K,Wirz W,Gressner AM,Müller R,Kiefer P

更新日期：2005-09-16 00:00:00

abstract：:The arylamide 2-acetylaminofluorene (AAF) is a powerful carcinogen displaying a marked promoting activity, also known to regulate expression of liver detoxifying proteins. In this study we identified CYP3A23, a major inducible cytochrome P-450 (CYP) isoform, as an AAF target in hepatocytes. Indeed, exposure to AAF of ...

journal_title：Biochemical and biophysical research communications

authors： Sparfel L,Payen L,Gilot D,Sidaway J,Morel F,Guillouzo A,Fardel O

更新日期：2003-01-10 00:00:00

abstract：:Cereblon (CRBN), the substrate receptor of an E3 ubiquitin ligase complex, is a target of thalidomide and thalidomide-derived immunomodulatory drugs (IMiDs). The binding of these IMiDs to CRBN alters the substrate specificity of the ligase, thereby mediating multiple effects that are exploited in cancer therapy. Howev...

journal_title：Biochemical and biophysical research communications

authors： Heim C,Maiwald S,Steinebach C,Collins MK,Strope J,Chau CH,Figg WD,Gütschow M,Hartmann MD

更新日期：2021-01-01 00:00:00

abstract：:Blebbistatin is a novel 1-phenyl-2-pyrrolidinone derivative capable of inhibiting non-muscle myosin II activity with a high degree of specificity. We examined the effects of blebbistatin on pancreatic adenocarcinoma cellular migration, invasion, adhesion, and spreading. Blebbistatin dose-dependently inhibited cellular...

journal_title：Biochemical and biophysical research communications

authors： Duxbury MS,Ashley SW,Whang EE

更新日期：2004-01-23 00:00:00

abstract：:A potent analog (HNG) of the endogenous peptide humanin protects against myocardial ischemia-reperfusion (MI-R) injury in vivo, decreasing infarct size and improving cardiac function. Since oxidative stress contributes to the damage from MI-R we tested the hypotheses that: (1) HNG offers cardioprotection through activ...

journal_title：Biochemical and biophysical research communications

authors： Klein LE,Cui L,Gong Z,Su K,Muzumdar R

更新日期：2013-10-18 00:00:00