当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > CircPRKCI-miR-545/589-E2F7 axis dysregulation mediates hydrogen peroxide-induced neuronal cell injury.

CircPRKCI-miR-545/589-E2F7 axis dysregulation mediates hydrogen peroxide-induced neuronal cell injury.

Abstract：

:Excessive oxidative stress induces significant injury and cytotoxicity to neuronal cells. The current study tested expression and the potential function of the circular RNA PRKCI (circPRKCI) in oxidative stress-injured neuronal cells. In cultured SH-SY5Y neuronal cells, hydrogen peroxide (H2O2) downregulated circPRKCI expression, causing accumulation of miR-545 and miR-589, but reduction of their target, the transcription factor E2F7. Importantly, ectopic overexpression of circPRKCI in SH-SY5Y cells significantly attenuated H2O2-induced cytotoxicity. Conversely, siRNA-mediated knockdown of circPRKCI induced SH-SY5Y cell death and apoptosis. Further studies demonstrated that H2O2-induced cytotoxicity in SH-SY5Y cells was inhibited by miR-545/589 inhibitors, but mimicked by miR-545/589 mimics. Importantly, CRISPR/Cas9-mediated knockout (KO) of E2F7 induced potent SH-SY5Y cell death and apoptosis. Furthermore, transfection of circPRKCI siRNA or miR-545/589 mimics were ineffective in E2F7 KO cells. In the primary human neurons, H2O2 stimulation similarly induced circPRKCI downregulation, miR-545/589 accumulation and E2F7 reduction. Moreover, H2O2-induced death and apoptosis in the primary neurons were significantly inhibited by circPRKCI overexpression or miR-545/589 inhibitors. Taken together, our results show that dysregulation of circPRKCI-miR-545/589-E2F7 axis mediated H2O2-induced neuronal cell injury. Targeting this novel cascade could be a fine strategy to protect neurons from oxidative stress.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Cheng Q,Cao X,Xue L,Xia L,Xu Y

doi

10.1016/j.bbrc.2019.04.131

subject

Has Abstract

pub_date

2019-06-25 00:00:00

pages

428-435

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(19)30781-8

journal_volume

514

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • GOLGA2 loss causes fibrosis with autophagy in the mouse lung and liver.

    abstract：:Autophagy is a biological recycling process via the self-digestion of organelles, proteins, and lipids for energy-consuming differentiation and homeostasis. The Golgi serves as a donor of the double-membraned phagophore for autophagosome assembly. In addition, recent studies have demonstrated that pulmonary and hepati...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.11.049

    authors： Park S,Kim S,Kim MJ,Hong Y,Lee AY,Lee H,Tran Q,Kim M,Cho H,Park J,Kim KP,Park J,Cho MH

    更新日期：2018-01-01 00:00:00

  • HGF-induced capillary morphogenesis of endothelial cells is regulated by Src.

    abstract：:The signal transduction pathway involved in hepatocyte growth factor (HGF)-induced capillary morphogenesis of endothelial cells was investigated. HGF-induced capillary morphogenesis of the murine spleen endothelial cell line MSS31 was inhibited by a Src family kinase inhibitor, PP2. Stable expression of kinase-inactiv...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.03.183

    authors： Kanda S,Kanetake H,Miyata Y

    更新日期：2006-06-02 00:00:00

  • Superior serum half life of albumin tagged TNF ligands.

    abstract：:Due to their immune stimulating and apoptosis inducing properties, ligands of the TNF family attract increasing interest as therapeutic proteins. A general limitation of in vivo applications of recombinant soluble TNF ligands is their notoriously rapid clearance from circulation. To improve the serum half life of the ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.04.134

    authors： Müller N,Schneider B,Pfizenmaier K,Wajant H

    更新日期：2010-06-11 00:00:00

  • Doc2: a novel brain protein having two repeated C2-like domains.

    abstract：:Two repeated C2-like domains interacting with Ca2+ and phospholipid are found in synaptotagmin and Rabphilin-3A which are implicated in neurotransmitter release. Here we have isolated a cDNA encoding a novel protein having two repeated C2-like domains from a human brain cDNA library. The isolated cDNA encodes a protei...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1062

    authors： Orita S,Sasaki T,Naito A,Komuro R,Ohtsuka T,Maeda M,Suzuki H,Igarashi H,Takai Y

    更新日期：1995-01-17 00:00:00

  • Ancient DNA in human bone remains from Pompeii archaeological site.

    abstract：:aDNA extraction and amplification procedures have been optimized for Pompeian human bone remains whose diagenesis has been determined by histological analysis. Single copy genes amplification (X and Y amelogenin loci and Y specific alphoid repeat sequences) have been performed and compared with anthropometric data on ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8881

    authors： Cipollaro M,Di Bernardo G,Galano G,Galderisi U,Guarino F,Angelini F,Cascino A

    更新日期：1998-06-29 00:00:00

  • Dominant-negative effects of LRRK2 heterodimers: a possible mechanism of neurodegeneration in Parkinson's disease caused by LRRK2 I2020T mutation.

    abstract：:Leucine-rich repeat kinase 2 (LRRK2) is the molecule responsible for autosomal-dominant Parkinson's disease (PD), PARK8, but the etiologic effects of its mutation remain unknown. In the present study, we investigated a novel mechanism for the neurodegeneration induced by I2020T mutant LRRK2. Using native gel electroph...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.11.113

    authors： Ohta E,Kawakami F,Kubo M,Obata F

    更新日期：2013-01-11 00:00:00

  • Cyclic strain-induced endothelial MMP-2: role in vascular smooth muscle cell migration.

    abstract：:Matrix metalloproteinases (MMPs) play a vital role in vasculature response to hemodynamic stimuli via the degradation of extracellular matrix substrates. In this study, we investigated the putative role of cyclic strain-induced endothelial MMP-2 (and MMP-9) expression and release in modulating bovine aortic smooth mus...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.05.174

    authors： von Offenberg Sweeney N,Cummins PM,Birney YA,Redmond EM,Cahill PA

    更新日期：2004-07-23 00:00:00

  • Independent induction of interleukin 6 and prostaglandin E2 by interleukin 1 in human articular chondrocytes.

    abstract：:Interleukin 6 is a cytokine with growth and differentiation activities on a number of cell types. Human articular chondrocytes produce interleukin 6 and this production appears to be constitutive but can be stimulated in a dose-dependent manner by interleukin 1. Other stimulators of interleukin 6 production in chondro...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)90988-y

    authors： Bunning RA,Russell RG,Van Damme J

    更新日期：1990-02-14 00:00:00

  • Essential roles of integrin-mediated signaling for the enhancement of malignant properties of melanomas based on the expression of GD3.

    abstract：:We reported that ganglioside GD3 enhances cell proliferation and invasion of melanomas causing stronger tyrosine-phosphorylation of p130Cas and paxillin after stimulation with fetal calf serum. Besides signals via growth factor/receptor, adhesion signals via integrin might be also enhanced by GD3. Here, roles of integ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.05.149

    authors： Ohkawa Y,Miyazaki S,Miyata M,Hamamura K,Furukawa K,Furukawa K

    更新日期：2008-08-15 00:00:00

  • Involvement of the G-protein-coupled receptor 4 in RANKL expression by osteoblasts in an acidic environment.

    abstract：:Osteoclast activity is enhanced in acidic environments following systemic or local inflammation. However, the regulatory mechanism of receptor activator of NF-κB ligand (RANKL) expression in osteoblasts under acidic conditions is not fully understood. In the present paper, we detected the mRNA expression of the G-prot...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.01.142

    authors： Okito A,Nakahama K,Akiyama M,Ono T,Morita I

    更新日期：2015-03-06 00:00:00

  • Low-concentration HCP1 inhibits apoptosis in vascular endothelial cells.

    abstract：:Vascular endothelial cell (VEC) apoptosis takes part in the development of various cardiovascular diseases. Heat shock protein 90 (HSP90) regulates apoptosis through various apoptosis associated client proteins. In previous study, we identified a novel HSP90 inhibitor HCP1 induced apoptosis in A549 human lung cancer c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.02.003

    authors： Wei Q,Zhang J,Su L,Zhao X,Zhao B,Miao J,Lin Z

    更新日期：2019-03-26 00:00:00

  • Role of cholesterol in ligand binding and G-protein coupling of serotonin1A receptors solubilized from bovine hippocampus.

    abstract：:The serotonin(1A) (5-HT(1A)) receptor is an important member of the superfamily of seven transmembrane domain G-protein-coupled receptors. We report here that solubilization of the hippocampal 5-HT(1A) receptor by the zwitterionic detergent CHAPS is accompanied by loss of membrane cholesterol which results in a reduct...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.12.102

    authors： Chattopadhyay A,Jafurulla M,Kalipatnapu S,Pucadyil TJ,Harikumar KG

    更新日期：2005-02-25 00:00:00

  • Adiponutrin: a multimeric plasma protein.

    abstract：:The interest in adiponutrin stems from adiponutrin variant I148M, which is strongly associated to non-alcoholic fatty liver disease. Adiponutrin has to date been considered to be solely an intracellular protein, with a role in lipid metabolism in liver and adipose tissue. However, a physiologically relevant role for a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.03.078

    authors： Winberg ME,Motlagh MK,Stenkula KG,Holm C,Jones HA

    更新日期：2014-04-18 00:00:00

  • Zinc-binding protein-89 (ZBP-89) cooperates with NF-κB to regulate expression of matrix metalloproteinases (MMPs) in response to inflammatory cytokines.

    abstract：:Matrix metalloproteinases (MMPs) have both protective and pathological roles in inflammation, and transcriptional mechanisms are important in regulating physiological levels to maintain health. Zinc-binding protein-89 (ZBP-89) is a transcription factor with roles in regulating vital cellular processes, acting through ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.02.045

    authors： Borghaei RC,Gorski G,Seutter S,Chun J,Khaselov N,Scianni S

    更新日期：2016-03-18 00:00:00

  • Development of mesenchymal stem cells partially originate from the neural crest.

    abstract：:Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal stem cells isolated from many adult tissues. Previous studies reported that MSCs can differentiate to both mesodermal and neural lineages by a phenomenon referred to as ''dedifferentiation'' or ''transdifferentiation''. However, since MSCs have only b...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.01.031

    authors： Morikawa S,Mabuchi Y,Niibe K,Suzuki S,Nagoshi N,Sunabori T,Shimmura S,Nagai Y,Nakagawa T,Okano H,Matsuzaki Y

    更新日期：2009-02-20 00:00:00

  • APP gene promoter constructs are preferentially expressed in the CNS and testis of transgenic mice.

    abstract：:Transgenic animals were used to examine the spatial and temporal regulation of the human beta amyloid precursor protein (APP) gene promoter region in vivo. A 2.9 kb DNA fragment encompassing the APP gene promoter was fused to the chloramphenical acetyltransferase (CAT) reporter gene (pAMY-CAT) or a partial cDNA encodi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.7728

    authors： Fox NW,Johnstone EM,Ward KE,Schrementi J,Little SP

    更新日期：1997-11-26 00:00:00

  • Cloning and sequence analysis of a cDNA encoding tetrameric carbonyl reductase of pig lung.

    abstract：:A cDNA for tetrameric carbonyl reductase was cloned from a pig lung cDNA library. The cDNA had an open reading frame encoding a protein of 244 amino acid residues with a predicted monomer molecular weight of 25,985. The authenticity of the cDNA was confirmed by a perfect match of 80 amino acids determined from sequenc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1967

    authors： Nakanishi M,Deyashiki Y,Nakayama T,Sato K,Hara A

    更新日期：1993-08-16 00:00:00

  • Expression of galectin-9 by IFN-γ stimulated human nasal polyp fibroblasts through MAPK, PI3K, and JAK/STAT signaling pathways.

    abstract：:Galectin-9 exhibited potent and selective eosinophil chemoattractant activity and attracted eosinophils in vitro and in vivo. Nasal polyposis is a chronic inflammatory disease of the upper airway characterized by the marked presence of inflammatory cells, particularly eosinophils. Thus, galectin-9 may be implicated in...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.06.110

    authors： Park WS,Jung WK,Park SK,Heo KW,Kang MS,Choi YH,Kim GY,Park SG,Seo SK,Yea SS,Liu KH,Shim EB,Kim DJ,Her M,Choi IW

    更新日期：2011-07-29 00:00:00

  • Expression and function of the atypical cadherin FAT1 in chronic liver disease.

    abstract：:Hepatic fibrosis can be considered as wound healing process in response to hepatocellular injury. Activation of hepatic stellate cells (HSCs) is a key event of hepatic fibrosis since activated HSCs are the cellular source of enhanced extracellular matrix deposition, and reversion of liver fibrosis is accompanied by cl...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.08.104

    authors： Valletta D,Czech B,Thasler WE,Müller M,Bosserhoff AK,Hellerbrand C

    更新日期：2012-09-28 00:00:00

  • Recognition of left-handed Z-DNA of short unmodified oligonucleotides under physiological ionic strength conditions.

    abstract：:The left-handed Z-DNA form of the short unmodified alternating guanine-cytosine oligonucleotides, 5'-(dGdC)(24) and 5'-(dGdC)(18), was selectively detected under physiological ionic strength and pH conditions using the anionic nickel(II) porphyrin, NiTPPS. No spectroscopic signal was observed for NiTPPS with any right...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.05.119

    authors： D'Urso A,Choi JK,Shabbir-Hussain M,Ngwa FN,Lambousis MI,Purrello R,Balaz M

    更新日期：2010-06-25 00:00:00

  • Analysis of laser scattering pattern as an early measure of apoptosis.

    abstract：:Light scattering pattern analysis (LSPA) was applied in the current study for accurate and sensitive detection of subtle changes in cell size, which occur in mouse thymocytes undergoing apoptosis. The decrease in cell diameter as measured by LSPA was found to be an early signal of apoptosis preceding the externalizati...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.6127

    authors： Shiffer Z,Zurgil N,Shafran Y,Deutsch M

    更新日期：2001-12-21 00:00:00

  • The 2',3'-dideoxyriboside of 2,6-diaminopurine and its 2',3'-didehydro derivative inhibit the deamination of 2',3'-dideoxyadenosine, an inhibitor of human immunodeficiency virus (HIV) replication.

    abstract：:The 2',3'-dideoxyriboside of 2,6-diaminopurine (ddDAPR) and its 2',3'-didehydro derivative (ddeDAPR) are poor substrates for adenosine deaminase (ADA) but potent inhibitors of the enzyme. Their Km values for ADA are of the same order of magnitude as those of the natural adenosine (Ado) and 2'-deoxyadenosine (dAdo), bu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91317-9

    authors： Balzarini J,Robins MJ,Zou RM,Herdewijn P,De Clercq E

    更新日期：1987-05-29 00:00:00

  • Senescence marker protein 30 inhibits angiotensin II-induced cardiac hypertrophy and diastolic dysfunction.

    abstract：BACKGROUND AND OBJECTIVE:Senescence marker protein 30 (SMP30) is assumed to behave as an anti-aging factor. Recently, we have demonstrated that deficiency of SMP30 exacerbates angiotensin II-induced cardiac hypertrophy, dysfunction and remodeling, suggesting that SMP30 may have a protective role in the heart. Thus, thi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.08.002

    authors： Misaka T,Suzuki S,Miyata M,Kobayashi A,Ishigami A,Shishido T,Saitoh S,Kubota I,Takeishi Y

    更新日期：2013-09-13 00:00:00

  • Computational studies on the decarboxylation of 2-(1-carboxy-1-hydroxyethyl)-3,4-dimethylthiazolium dipolar ion, an analog of the complex of pyruvic acid and coenzyme of the pyruvate decarboxylase.

    abstract：:We have obtained the optimized geometrical structure of 2-(1-carboxy-1-hydroxyethyl)-3,4-dimethylthiazolium dipolar ion and investigated its geometric and electric changes during decarboxylation process by the MNDO-PM3 method, a molecular orbital method. The salient features of the optimized structure are that the dih...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.2064

    authors： Nakajima Y,Sakagishi Y,Shiibashi M,Suzuki Y,Kato H

    更新日期：1993-08-31 00:00:00

  • Role of S6K1 in regulation of SREBP1c expression in the liver.

    abstract：:The transcription factor sterol regulatory element-binding protein 1c (SREBP1c) plays an important role in the control of fatty acid metabolism in the liver. Evidence suggests that mammalian target of rapamycin (mTOR) complex 1 (mTORC1) contributes to the regulation of SREBP1c expression, but signaling downstream of m...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.07.038

    authors： Li S,Ogawa W,Emi A,Hayashi K,Senga Y,Nomura K,Hara K,Yu D,Kasuga M

    更新日期：2011-08-26 00:00:00

  • RvD1 inhibits TNFα-induced c-Myc expression in normal intestinal epithelial cells and destabilizes hyper-expressed c-Myc in colon cancer cells.

    abstract：:Inflammatory bowel diseases, including ulcerative colitis and Crohn's disease, are persistent disorders that lead to development of colitis-associated cancer (CAC). Facilitated resolution of colitis has been addressed as a novel therapeutic strategy to control development of CAC. Resolvin D1 (RvD1) is an endogenous li...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.12.171

    authors： Zhong X,Lee HN,Surh YJ

    更新日期：2018-02-05 00:00:00

  • Analysis of the potency of various low molecular weight chemical chaperones to prevent protein aggregation.

    abstract：:Newly translated proteins must undergo proper folding to ensure their function. To enter a low energy state, misfolded proteins form aggregates, which are associated with many degenerative diseases, such as Huntington's disease and chronic kidney disease (CKD). Recent studies have shown the use of low molecular weight...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.03.019

    authors： Upagupta C,Carlisle RE,Dickhout JG

    更新日期：2017-04-22 00:00:00

  • Cloning and characterization of mouse disabled 2 interacting protein 2, a mouse orthologue of human NOSTRIN.

    abstract：:The mouse disabled 2 interacting protein 2 (mDaIP2) had been obtained through yeast two hybrid system. It consists of 506 amino acids and its calculated molecular weight is 57.7 kDa. The protein contains N-terminal FCH domain and C-terminal SH3 domain. The SH3 domain interacts with the proline rich domain of mDab2 whi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.11.079

    authors： Choi YJ,Cho SY,Kim HW,Kim JA,Bae SH,Park SS

    更新日期：2005-01-21 00:00:00

  • Biochemical characterization of the phagocytic giant cell receptor for Dictyostelium discoideum amoebae: identification by cell blotting.

    abstract：:A critical aspect of sexual development in Dictyostelium is the selection of "self" as a targeted food source by the phagocytic zygotic giant cell (ZGC). It has previously been demonstrated that phagocytic giant cells preferentially take up amoebae of the same species suggesting that the process is mediated by a speci...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.5990

    authors： Lewis KE,Jamieson JC

    更新日期：1997-01-23 00:00:00

  • Evidence for proteasomal degradation of Kv1.5 channel protein.

    abstract：BACKGROUND:The voltage-gated potassium channel Kv1.5 plays a critical role in the maintenance of the membrane potential. While protein degradation is one of the major mechanisms for the regulation of channel functions, little is known on the degradation mechanism of Kv1.5. METHODS AND RESULTS:Kv1.5 was expressed in CO...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.09.053

    authors： Kato M,Ogura K,Miake J,Sasaki N,Taniguchi S,Igawa O,Yoshida A,Hoshikawa Y,Murata M,Nanba E,Kurata Y,Kawata Y,Ninomiya H,Morisaki T,Kitakaze M,Hisatome I

    更新日期：2005-11-11 00:00:00