Adipogenic differentiation of adipose tissue derived adult stem cells in nude mouse.

Abstract:

:We evaluated the use of a combination of adipose tissue derived adult stem cells (ADSCs) obtained from liposuction and injectable poly(lactic-co-glycolic acid) (PLGA) spheres for adipose tissue engineering. Adipogenesis was examined in nude mice injected subcutaneously with ADSCs (group I), PLGA spheres (group II), or ADSCs attached PLGA spheres (group III) cultured in adipogenic medium for 7 days. After 4 and 8 weeks, newly formed adipose tissue was observed in groups II and III but not in group I. Oil red O staining of newly formed tissue showed that there was substantially more tissue regeneration and adipogenic differentiation in group III than in group II. RT-PCR confirmed that, after 8 weeks, the PLGA-attached ADSCs had fully differentiated into adipocytes. This study provides significant evidence that ADSCs and PLGA spheres can be used in a clinical setting to generate adipose tissue as a noninvasive soft tissue filler.

authors

Choi YS,Cha SM,Lee YY,Kwon SW,Park CJ,Kim M

doi

10.1016/j.bbrc.2006.04.128

subject

Has Abstract

pub_date

2006-06-30 00:00:00

pages

631-7

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)00941-7

journal_volume

345

pub_type

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